X0202 4/A 2004-09-08 2004-09-10 0 0001145404 CRITICAL THERAPEUTICS INC CRTX 0001210905 RUBIN PAUL D C/O CRITICAL THERAPEUTICS, INC. 60 WESTVIEW STREET LEXINGTON MA 02421 1 1 0 0 President and CEO Options to Purchase Common Stock 5.99 2004-09-08 4 A 0 325000 A 2014-09-07 Common Stock 325000 325000 D This Form 4/A is being filed by the reporting person in order to accurately reflect the vesting schedule for this option. 16.7% of such options to become exercisable on September 8, 2005 and 83.3% of such options to become exercisable in 60 equal monthly installments beginning one month thereafter; provided, however, 75% of the original number of shares shall become exercisable based upon the satisfaction of two corporate objectives as determined by the Compensation Committee of the Board of Directors. The exercisability of this option would be accelerated by two years of vesting if the employment of the holder is terminated within one year after a change of control of the Issuer. Not applicable. /s/ Paul D. Rubin, M.D. 2004-09-14