X0202 4/A 2003-12-19 2004-06-03 0 0001145404 CRITICAL THERAPEUTICS INC CRTX 0001210905 RUBIN PAUL D C/O CRITICAL THERAPEUTICS, INC. 60 WESTVIEW STREET LEXINGTON MA 02421 1 1 0 0 President and CEO Common Stock 2004-01-21 4 M 0 13332.0000 0.3750 A 13332.0000 D Common Stock 2004-01-21 5 G 0 E 6666.0000 0 D 6666.0000 D Common Stock 2004-01-21 5 G 0 E 6666.0000 0 A 6666.0000 I Held by daughter Common Stock 2004-01-21 5 G 0 E 6666.0000 0 D 0 D Common Stock 2004-02-02 4 M 0 89196.0000 0.3750 A 89196.0000 D Common Stock 2004-02-02 4 M 0 4136.0000 1.0500 A 93332.0000 D Common Stock 2004-02-02 5 G 0 E 21000.0000 0 D 72332.0000 D Common Stock 2004-02-02 5 G 0 E 21000.0000 0 D 51332.0000 D Common Stock 2004-02-02 5 G 0 E 51332.0000 0 D 0 D Common Stock 2004-02-02 5 G 0 E 51332.0000 0 A 57998.0000 I Held by GRAT Options to Purchase 1.0500 2003-12-19 4 A 0 502841.0000 A 2013-12-19 Common Stock 502841.0000 502841.0000 D Options to Purchase 0.3750 2004-01-21 4 M 0 13332.0000 D 2012-10-09 Common Stock 13332.0000 276161.0000 D Options to Purchase 0.3750 2004-02-02 4 M 0 89196.0000 D 2012-10-09 Common Stock 89196.0000 186965.0000 D Options to Purchase 1.0500 2004-02-02 4 M 0 4136.0000 D 2013-12-19 Common Stock 4136.0000 498705.0000 D Series B Convertible Preferred Stock 2004-03-05 4 P 0 28571.0000 1.4000 A Common Stock 7618.0000 57142.0000 D These securities transactions were unintentionally omitted on the Form 4 of the reporting person. These shares were a gift to the reporting person's daughter who shares the reporting person's household. The reporting person disclaims beneficial ownership of these shares except to the extent of his pecuniary intertest therein. This report should not be deemed an admission that the reporting person is the beneficial owner of his daughter's shares for purposes of Section 16 or for any other purpose. These shares were transferred to The Paul D. Rubin GRAT 2004, for which the reporting person?s wife serves as a co-trustee for the benefit of the reporting person's descendants. The reporting person disclaims beneficial ownership of these shares except to the extent of his pecuniary intertest therein. This report should not be deemed an admission that the reporting person is the beneficial owner of these shares for purposes of Section 16 or for any other purpose. One-quarter of the options to purchase 502,841 shares of Common Stock of the Issuer vested on December 19, 2003. An additional one-quarter of such options vest under a schedule providing for one-quarter to become exercisable on December 19, 2004 and three-quarters to become exercisable in 36 equal monthly installments beginning one month thereafter. The remainder of such options vest in four equal annual installments on each of December 31, 2004, 2005, 2006 and 2007. Not applicable. Of the original options granted to purchase 289,493 shares of Common Stock of the Issuer, one-quarter of such options vested on July 29, 2003. The remainder of such options began vesting in 36 successive, equal monthly installments on August 29, 2003. The Series B Convertible Preferred Stock converted into Common Stock of the Issuer on a one-for-3.75 basis upon the closing of the Issuer's initial public offering. These shares were immediately convertible into Common Stock of the Issuer. They had no expiration date. The share numbers and prices set forth in this report reflect the one-for-3.75 reverse stock split of the Common Stock of the Issuer effected on May 20, 2004. /s/ Trevor Phillips, Attorney-in-Fact 2004-06-28