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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 L130OgUvM5sK6j/upyl9CqF4eBQoayuNJ+g0HRgwcTlEc3SNZLCO1/2Q64A/gVMi
 Ns4QSGy2ivEnx3bTqfJfyA==

<SEC-DOCUMENT>0001209191-08-059886.txt : 20081110
<SEC-HEADER>0001209191-08-059886.hdr.sgml : 20081110
<ACCEPTANCE-DATETIME>20081110200818
ACCESSION NUMBER:		0001209191-08-059886
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20081031
FILED AS OF DATE:		20081110
DATE AS OF CHANGE:		20081110

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CORNERSTONE THERAPEUTICS INC
		CENTRAL INDEX KEY:			0001145404
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043523569
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2000 REGENCY PARKWAY
		STREET 2:		SUITE 255
		CITY:			CARY
		STATE:			NC
		ZIP:			27518
		BUSINESS PHONE:		919-678-6611

	MAIL ADDRESS:	
		STREET 1:		2000 REGENCY PARKWAY
		STREET 2:		SUITE 255
		CITY:			CARY
		STATE:			NC
		ZIP:			27518

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CRITICAL THERAPEUTICS INC
		DATE OF NAME CHANGE:	20010719

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Cornerstone Biopharma Holdings, Ltd.
		CENTRAL INDEX KEY:			0001434508
		STATE OF INCORPORATION:			1A
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-50767
		FILM NUMBER:		081177527

	BUSINESS ADDRESS:	
		STREET 1:		2000 REGENCY PARKWAY
		STREET 2:		SUITE 255
		CITY:			CARY
		STATE:			NC
		ZIP:			27518
		BUSINESS PHONE:		(919) 678-6611

	MAIL ADDRESS:	
		STREET 1:		2000 REGENCY PARKWAY
		STREET 2:		SUITE 255
		CITY:			CARY
		STATE:			NC
		ZIP:			27518
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc3.xml
<DESCRIPTION>FORM 3 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-10-31</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001145404</issuerCik>
        <issuerName>CORNERSTONE THERAPEUTICS INC</issuerName>
        <issuerTradingSymbol>CRTX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001434508</rptOwnerCik>
            <rptOwnerName>Cornerstone Biopharma Holdings, Ltd.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2000 REGENCY PARKWAY</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 255</rptOwnerStreet2>
            <rptOwnerCity>CARY</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>27518</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3202225</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes></footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Craig A. Collard, Director</signatureName>
        <signatureDate>2008-11-10</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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