Income Taxes (Details Textual) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Jan. 01, 2021
Income Taxes [Line Items]
Deferred tax assets	$ 323,550	$ 247,145
Unrecognized tax benefits that would impact effective tax	17,800	16,500	$ 18,700
Income tax, penalties and interest (expense) benefit	100	(100)	$ 100
Income tax, accrued interest and penalties	100	$ 100
Remaining unrecognized tax positions	0
Research and Development [Member] | California Tax Authority [Member]
Income Taxes [Line Items]
Net research and development carryforwards	41,300
Federal Tax Authority [Member]
Income Taxes [Line Items]
Net operating loss carryforwards	$ 1,800
Operating loss carryforwards expiration year	2026
Federal Tax Authority [Member] | Research and Development [Member]
Income Taxes [Line Items]
Net research and development carryforwards	$ 7,900
Federal tax credit carryforwards, expiration year	2038
State and Local Jurisdiction [Member]
Income Taxes [Line Items]
Net operating loss carryforwards	$ 55,100
Operating loss carryforwards expiration year	2021
Foreign Tax Authority [Member]
Income Taxes [Line Items]
Net operating loss carryforwards	$ 300
ASU 2020-06 [Member]
Income Taxes [Line Items]
Net increase (decrease) in deferred tax assets and liabilities	(28,900)
Decrease in valuation allowance of deferred taxes	900
Simplify Medical [Member]
Income Taxes [Line Items]
Net increase (decrease) in deferred tax assets and liabilities	$ 10,700
Deferred tax assets				$ 700