Consolidated Statements of Equity - USD ($) shares in Thousands, $ in Thousands	Total	Adjustment For Modified Retrospective Adoption Of Accounting Standard [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]	Additional Paid-in Capital [Member] Adjustment For Modified Retrospective Adoption Of Accounting Standard [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Retained Earnings (Accumulated Deficit) [Member]	Retained Earnings (Accumulated Deficit) [Member] Adjustment For Modified Retrospective Adoption Of Accounting Standard [Member]	Treasury Stock [Member]
Beginning Balance at Dec. 31, 2018	$ 834,525		$ 61	$ 1,397,829		$ (8,628)	$ 17,241		$ (571,978)
Beginning Balance, Shares at Dec. 31, 2018			56,648						(5,116)
Issuance of common stock under employee and director stock option and purchase plans	(8,063)		$ 1	7,724					$ (15,788)
Issuance of common stock under employee and director equity option and purchase plans, Shares			805						(264)
Stock-based compensation expense	24,096			24,096
Issuance of common stock in connection with royalty milestone achievement, Shares			72
Consolidated net income (loss)	65,234						65,234
Consideration paid in excess of non-controlling interests	205			205
Other comprehensive income (loss)	(790)					(790)
Ending Balance at Dec. 31, 2019	915,207		$ 62	1,429,854		(9,418)	82,475		$ (587,766)
Ending Balance, Shares at Dec. 31, 2019			57,525						(5,380)
Issuance of common stock under employee and director stock option and purchase plans	505			6,621					$ (6,116)
Issuance of common stock under employee and director equity option and purchase plans, Shares			420						(104)
Stock-based compensation expense	25,778			25,778
Tax benefits related to convertible note issuance	484			484
Shares repurchased	(75,000)								$ (75,000)
Shares repurchased ,Shares									(1,085)
Sale of warrants	93,915			93,915
Convertible note hedge	(115,592)			(115,592)
Equity component of convertible note issuance	115,559			115,559
Debt issuance costs attributable to convertible feature	(1,921)			(1,921)
Reclassification of redeemable equity component of senior convertible notes	(4,697)			(4,697)
Consolidated net income (loss)	(37,153)						(37,153)
Other comprehensive income (loss)	1,833					1,833
Ending Balance at Dec. 31, 2020	918,918	$ (82,689)	$ 62	1,550,001	$ (147,161)	(7,585)	45,322	$ 64,472	$ (668,882)
Ending Balance, Shares at Dec. 31, 2020			57,945						(6,569)
Issuance of common stock under employee and director stock option and purchase plans	(2,595)		$ 1	6,217					$ (8,813)
Issuance of common stock under employee and director equity option and purchase plans, Shares			524						(131)
Stock-based compensation expense	25,292			25,292
Shares repurchased			$ 0
Settlement of convertible note hedge				53					$ (53)
Settlement of convertible note hedge, Shares			(1)
Equity component of convertible note issuance	574			574
Equity component of convertible note settlement, Shares			1
Consolidated net income (loss)	(64,086)						(64,086)
Other comprehensive income (loss)	(207)					(207)
Ending Balance at Dec. 31, 2021	$ 795,207		$ 63	$ 1,434,976		$ (7,792)	$ 45,708		$ (677,748)
Ending Balance, Shares at Dec. 31, 2021			58,469						(6,700)