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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 GpEcmWCW1B13LnGOYmVmS3LeGgWHxw27L/c36LI9vvJctosiKTVJFQWITWkh3d9C
 zEDjuEjXk7DR7u66h3M3pQ==

<SEC-DOCUMENT>0000904454-05-000313.txt : 20050611
<SEC-HEADER>0000904454-05-000313.hdr.sgml : 20050611
<ACCEPTANCE-DATETIME>20050609170714
ACCESSION NUMBER:		0000904454-05-000313
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050609
FILED AS OF DATE:		20050609
DATE AS OF CHANGE:		20050609

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NUVASIVE INC
		CENTRAL INDEX KEY:			0001142596
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				330768598
		STATE OF INCORPORATION:			DE

	BUSINESS ADDRESS:	
		STREET 1:		4545 TOWNE CENTRE COURT
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		(858) 909-1800

	MAIL ADDRESS:	
		STREET 1:		4545 TOWNE CENTRE COURT
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BLAIR JAMES C
		CENTRAL INDEX KEY:			0001024000
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-50744
		FILM NUMBER:		05888104

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		6194572553

	MAIL ADDRESS:	
		STREET 1:		5880 PACIFIC CENTER BLVD
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121-4204
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-06-09</periodOfReport>

    <issuer>
        <issuerCik>0001142596</issuerCik>
        <issuerName>NUVASIVE INC</issuerName>
        <issuerTradingSymbol>NUVA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001024000</rptOwnerCik>
            <rptOwnerName>BLAIR JAMES C</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O DOMAIN ASSOCIATES, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>ONE PALMER SQUARE</rptOwnerStreet2>
            <rptOwnerCity>PRINCETON</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08542</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2005-06-09</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>10400</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>15.47</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>20804</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>DP IV Associates, L.P.</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The Reporting Person also indirectly beneficially owns 8,000 shares of Common Stock held by Domain Associates, L.L.C., 5,840 shares held by One Palmer Square Associates IV, LLC and 1,168,455 shares of Common Stock held by Domain Partners IV, L.P.  The Reporting Person is a managing member of Domain Associates, L.L.C. and a managing member of One Palmer Square Associates IV, L.L.C., the sole general partner of Domain Partners IV, L.P. and DP IV Associates, L.P.  Pursuant to Instruction 4(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by each such entity.  The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his pecuniary interest therein and/or that are not actually distributed to him.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Kathleen K. Schoemaker, Attorney-in-Fact</signatureName>
        <signatureDate>2005-06-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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