<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019d9cbf-bb3e-7614-84d6-f7088ef060fd,g:b9555865-3ea2-4e2d-90f8-05a9aeaaa73a-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.mastercard.us/role/Cover" xlink:type="simple" xlink:href="ma-20260331.xsd#Cover"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019d9cbf-bcc1-7d7a-8c15-a9fc23e007f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_us-gaap_StatementTable_019d9cbf-bcc1-7d7a-8c15-a9fc23e007f7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-7f4a-a39b-d3d3ad4d72cb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019d9cbf-bcc1-7d7a-8c15-a9fc23e007f7" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-7f4a-a39b-d3d3ad4d72cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7f4a-a39b-d3d3ad4d72cb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-7f4a-a39b-d3d3ad4d72cb" xlink:to="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7f4a-a39b-d3d3ad4d72cb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7f2e-b2c3-6f4a7bec8321" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-7f4a-a39b-d3d3ad4d72cb" xlink:to="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7f2e-b2c3-6f4a7bec8321" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d9cbf-bcc1-7b41-8e94-1b4d0748ca2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7f2e-b2c3-6f4a7bec8321" xlink:to="loc_us-gaap_CommonClassAMember_019d9cbf-bcc1-7b41-8e94-1b4d0748ca2d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_TwoPointOnePercentNotesDue2027Member_019d9cbf-bcc1-78da-9a37-dc88894ae2e2" xlink:href="ma-20260331.xsd#ma_TwoPointOnePercentNotesDue2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7f2e-b2c3-6f4a7bec8321" xlink:to="loc_ma_TwoPointOnePercentNotesDue2027Member_019d9cbf-bcc1-78da-9a37-dc88894ae2e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A1NotesDue2029Member_019d9cbf-bcc1-76fc-ad68-d2bebcdb288b" xlink:href="ma-20260331.xsd#ma_A1NotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7f2e-b2c3-6f4a7bec8321" xlink:to="loc_ma_A1NotesDue2029Member_019d9cbf-bcc1-76fc-ad68-d2bebcdb288b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_TwoPointFivePercentNotesDue2030Member_019d9cbf-bcc1-7230-9e37-3ef568469d22" xlink:href="ma-20260331.xsd#ma_TwoPointFivePercentNotesDue2030Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7f2e-b2c3-6f4a7bec8321" xlink:to="loc_ma_TwoPointFivePercentNotesDue2030Member_019d9cbf-bcc1-7230-9e37-3ef568469d22" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019d9cbf-bcc1-7eb5-b66a-7f577226277b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7f2e-b2c3-6f4a7bec8321" xlink:to="loc_us-gaap_CommonClassBMember_019d9cbf-bcc1-7eb5-b66a-7f577226277b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019d9cbf-bcc1-7773-b349-0c3877182716" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_DocumentType_019d9cbf-bcc1-7773-b349-0c3877182716" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_019d9cbf-bcc1-7a36-9d92-26b5001c7a70" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentQuarterlyReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_DocumentQuarterlyReport_019d9cbf-bcc1-7a36-9d92-26b5001c7a70" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019d9cbf-bcc1-7002-a5da-ff0dd9d82c47" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_DocumentPeriodEndDate_019d9cbf-bcc1-7002-a5da-ff0dd9d82c47" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_019d9cbf-bcc1-7198-b100-6cca1910b3f0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_DocumentTransitionReport_019d9cbf-bcc1-7198-b100-6cca1910b3f0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019d9cbf-bcc1-7614-823a-f640c026d3aa" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityFileNumber_019d9cbf-bcc1-7614-823a-f640c026d3aa" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019d9cbf-bcc1-701c-a6a0-f05a045caa4c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityRegistrantName_019d9cbf-bcc1-701c-a6a0-f05a045caa4c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019d9cbf-bcc1-7ba6-b1e1-574dea9a7d21" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019d9cbf-bcc1-7ba6-b1e1-574dea9a7d21" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019d9cbf-bcc1-7de5-9c11-b7b422a8a8ac" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityTaxIdentificationNumber_019d9cbf-bcc1-7de5-9c11-b7b422a8a8ac" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019d9cbf-bcc1-7921-a83e-18bfa8805dac" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityAddressAddressLine1_019d9cbf-bcc1-7921-a83e-18bfa8805dac" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019d9cbf-bcc1-79b8-8796-ee9b25ea7445" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityAddressPostalZipCode_019d9cbf-bcc1-79b8-8796-ee9b25ea7445" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019d9cbf-bcc1-7409-826e-be37f27350ec" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityAddressCityOrTown_019d9cbf-bcc1-7409-826e-be37f27350ec" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019d9cbf-bcc1-7919-8e69-8131a9f52741" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityAddressStateOrProvince_019d9cbf-bcc1-7919-8e69-8131a9f52741" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019d9cbf-bcc1-7e64-ba26-fafccd9c2243" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_CityAreaCode_019d9cbf-bcc1-7e64-ba26-fafccd9c2243" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019d9cbf-bcc1-72af-b8ca-5e9db072097d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_LocalPhoneNumber_019d9cbf-bcc1-72af-b8ca-5e9db072097d" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019d9cbf-bcc1-775a-b919-afd10f9d4101" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_Security12bTitle_019d9cbf-bcc1-775a-b919-afd10f9d4101" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019d9cbf-bcc1-7325-b219-d7b25b5d2770" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_TradingSymbol_019d9cbf-bcc1-7325-b219-d7b25b5d2770" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019d9cbf-bcc1-78d7-bac0-7c825e3af7e5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_SecurityExchangeName_019d9cbf-bcc1-78d7-bac0-7c825e3af7e5" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_019d9cbf-bcc1-7e89-9b4e-0627cac56dcb" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityCurrentReportingStatus_019d9cbf-bcc1-7e89-9b4e-0627cac56dcb" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_019d9cbf-bcc1-7d15-a7c0-d243e08e5bca" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityInteractiveDataCurrent_019d9cbf-bcc1-7d15-a7c0-d243e08e5bca" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_019d9cbf-bcc1-747a-95e9-9848f79e4eb5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityFilerCategory_019d9cbf-bcc1-747a-95e9-9848f79e4eb5" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_019d9cbf-bcc1-7328-9fd0-3005368c2362" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntitySmallBusiness_019d9cbf-bcc1-7328-9fd0-3005368c2362" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019d9cbf-bcc1-78a9-8b50-f13bbd02dd32" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityEmergingGrowthCompany_019d9cbf-bcc1-78a9-8b50-f13bbd02dd32" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_019d9cbf-bcc1-746d-9e8a-395053faa5b7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityShellCompany_019d9cbf-bcc1-746d-9e8a-395053faa5b7" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_019d9cbf-bcc1-7bb2-8248-b1345025ef2b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_019d9cbf-bcc1-7bb2-8248-b1345025ef2b" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019d9cbf-bcc1-7fcb-8908-681eb3baa2a3" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_EntityCentralIndexKey_019d9cbf-bcc1-7fcb-8908-681eb3baa2a3" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_019d9cbf-bcc1-78f0-be13-05d7b9c13cdd" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_CurrentFiscalYearEndDate_019d9cbf-bcc1-78f0-be13-05d7b9c13cdd" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_019d9cbf-bcc1-74c8-ab32-f209a9566592" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_DocumentFiscalYearFocus_019d9cbf-bcc1-74c8-ab32-f209a9566592" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_019d9cbf-bcc1-74c4-84ff-856559394b65" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_DocumentFiscalPeriodFocus_019d9cbf-bcc1-74c4-84ff-856559394b65" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019d9cbf-bcc1-740d-b02c-2c93a818ab21" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7a52-88e7-54975dc134f1" xlink:to="loc_dei_AmendmentFlag_019d9cbf-bcc1-740d-b02c-2c93a818ab21" xlink:type="arc" order="28"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="ma-20260331.xsd#ConsolidatedBalanceSheets"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7401-9608-c1001c975afd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019d9cbf-bcc1-7bb7-b1d3-5c75c74535a9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7401-9608-c1001c975afd" xlink:to="loc_us-gaap_StatementTable_019d9cbf-bcc1-7bb7-b1d3-5c75c74535a9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-78e4-a5c4-28a15605a9a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019d9cbf-bcc1-7bb7-b1d3-5c75c74535a9" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-78e4-a5c4-28a15605a9a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-78e4-a5c4-28a15605a9a0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-78e4-a5c4-28a15605a9a0" xlink:to="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-78e4-a5c4-28a15605a9a0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7119-9154-d9ccad884303" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-78e4-a5c4-28a15605a9a0" xlink:to="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7119-9154-d9ccad884303" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d9cbf-bcc1-79c6-8e21-a0fbaf849f5d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7119-9154-d9ccad884303" xlink:to="loc_us-gaap_CommonClassAMember_019d9cbf-bcc1-79c6-8e21-a0fbaf849f5d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019d9cbf-bcc1-7dbf-9ab0-2b0eb60b3a69" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7119-9154-d9ccad884303" xlink:to="loc_us-gaap_CommonClassBMember_019d9cbf-bcc1-7dbf-9ab0-2b0eb60b3a69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_019d9cbf-bcc1-7853-9f10-4aa3d2ae0f9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7401-9608-c1001c975afd" xlink:to="loc_us-gaap_AssetsAbstract_019d9cbf-bcc1-7853-9f10-4aa3d2ae0f9b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_019d9cbf-bcc1-7ca4-9e70-93ef71a1e154" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d9cbf-bcc1-7853-9f10-4aa3d2ae0f9b" xlink:to="loc_us-gaap_AssetsCurrentAbstract_019d9cbf-bcc1-7ca4-9e70-93ef71a1e154" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019d9cbf-bcc1-7c75-864e-b613d518a344" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d9cbf-bcc1-7ca4-9e70-93ef71a1e154" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019d9cbf-bcc1-7c75-864e-b613d518a344" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019d9cbf-bcc1-7e49-aad6-5b55a9de6502" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d9cbf-bcc1-7ca4-9e70-93ef71a1e154" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019d9cbf-bcc1-7e49-aad6-5b55a9de6502" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsAssetsCurrent_019d9cbf-bcc1-7d8c-8ee7-0c446ee7fe3a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepositsAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d9cbf-bcc1-7ca4-9e70-93ef71a1e154" xlink:to="loc_us-gaap_DepositsAssetsCurrent_019d9cbf-bcc1-7d8c-8ee7-0c446ee7fe3a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Investments_019d9cbf-bcc1-7348-9b0e-7cdfaf36850c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Investments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d9cbf-bcc1-7ca4-9e70-93ef71a1e154" xlink:to="loc_us-gaap_Investments_019d9cbf-bcc1-7348-9b0e-7cdfaf36850c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019d9cbf-bcc1-7b04-96b2-86fe7ab4788f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d9cbf-bcc1-7ca4-9e70-93ef71a1e154" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019d9cbf-bcc1-7b04-96b2-86fe7ab4788f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_SettlementDueFromCustomers_019d9cbf-bcc1-7de0-9f0b-873086bb4ac5" xlink:href="ma-20260331.xsd#ma_SettlementDueFromCustomers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d9cbf-bcc1-7ca4-9e70-93ef71a1e154" xlink:to="loc_ma_SettlementDueFromCustomers_019d9cbf-bcc1-7de0-9f0b-873086bb4ac5" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019d9cbf-bcc1-76b3-a3b9-986b60f5db37" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d9cbf-bcc1-7ca4-9e70-93ef71a1e154" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019d9cbf-bcc1-76b3-a3b9-986b60f5db37" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019d9cbf-bcc1-7df9-897a-cef1806ebb47" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d9cbf-bcc1-7ca4-9e70-93ef71a1e154" xlink:to="loc_us-gaap_AssetsCurrent_019d9cbf-bcc1-7df9-897a-cef1806ebb47" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019d9cbf-bcc1-7307-a4fd-69632e77c67f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d9cbf-bcc1-7853-9f10-4aa3d2ae0f9b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019d9cbf-bcc1-7307-a4fd-69632e77c67f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019d9cbf-bcc1-7462-9e5b-ae1ce56be64f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d9cbf-bcc1-7853-9f10-4aa3d2ae0f9b" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019d9cbf-bcc1-7462-9e5b-ae1ce56be64f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019d9cbf-bcc1-74d8-9be8-6f374fd3c192" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d9cbf-bcc1-7853-9f10-4aa3d2ae0f9b" xlink:to="loc_us-gaap_Goodwill_019d9cbf-bcc1-74d8-9be8-6f374fd3c192" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019d9cbf-bcc1-749f-b11a-66b8173fa4af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d9cbf-bcc1-7853-9f10-4aa3d2ae0f9b" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019d9cbf-bcc1-749f-b11a-66b8173fa4af" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019d9cbf-bcc1-7f7d-875b-7f2d30d417e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d9cbf-bcc1-7853-9f10-4aa3d2ae0f9b" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019d9cbf-bcc1-7f7d-875b-7f2d30d417e6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019d9cbf-bcc1-7389-b47f-278817cd942b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d9cbf-bcc1-7853-9f10-4aa3d2ae0f9b" xlink:to="loc_us-gaap_Assets_019d9cbf-bcc1-7389-b47f-278817cd942b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d9cbf-bcc1-73b3-b97e-2e3e8e36a770" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-7401-9608-c1001c975afd" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d9cbf-bcc1-73b3-b97e-2e3e8e36a770" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_019d9cbf-bcc1-7b81-af60-d0fd12d0e742" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d9cbf-bcc1-73b3-b97e-2e3e8e36a770" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_019d9cbf-bcc1-7b81-af60-d0fd12d0e742" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019d9cbf-bcc1-7354-9b35-2428598de770" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d9cbf-bcc1-7b81-af60-d0fd12d0e742" xlink:to="loc_us-gaap_AccountsPayableCurrent_019d9cbf-bcc1-7354-9b35-2428598de770" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_SettlementDueToCustomers_019d9cbf-bcc1-707e-b616-c17e44cb8649" xlink:href="ma-20260331.xsd#ma_SettlementDueToCustomers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d9cbf-bcc1-7b81-af60-d0fd12d0e742" xlink:to="loc_ma_SettlementDueToCustomers_019d9cbf-bcc1-707e-b616-c17e44cb8649" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_ContractWithCustomerLiabilityRestrictedSecurityDepositsCurrent_019d9cbf-bcc1-78cc-881d-89e70eb304d1" xlink:href="ma-20260331.xsd#ma_ContractWithCustomerLiabilityRestrictedSecurityDepositsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d9cbf-bcc1-7b81-af60-d0fd12d0e742" xlink:to="loc_ma_ContractWithCustomerLiabilityRestrictedSecurityDepositsCurrent_019d9cbf-bcc1-78cc-881d-89e70eb304d1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_019d9cbf-bcc1-7c42-8ef7-fddd5c2a7c2a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d9cbf-bcc1-7b81-af60-d0fd12d0e742" xlink:to="loc_us-gaap_LitigationReserveCurrent_019d9cbf-bcc1-7c42-8ef7-fddd5c2a7c2a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019d9cbf-bcc1-7af7-882c-bbb1ab7734c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d9cbf-bcc1-7b81-af60-d0fd12d0e742" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019d9cbf-bcc1-7af7-882c-bbb1ab7734c1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019d9cbf-bcc1-7e73-95e9-f0193b87c037" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d9cbf-bcc1-7b81-af60-d0fd12d0e742" xlink:to="loc_us-gaap_LongTermDebtCurrent_019d9cbf-bcc1-7e73-95e9-f0193b87c037" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019d9cbf-bcc1-709b-b1b4-5fda5fd3b06d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d9cbf-bcc1-7b81-af60-d0fd12d0e742" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019d9cbf-bcc1-709b-b1b4-5fda5fd3b06d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019d9cbf-bcc1-7772-aeed-a93865bc83ad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d9cbf-bcc1-7b81-af60-d0fd12d0e742" xlink:to="loc_us-gaap_LiabilitiesCurrent_019d9cbf-bcc1-7772-aeed-a93865bc83ad" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019d9cbf-bcc1-79ba-89df-4f69afb158a9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d9cbf-bcc1-73b3-b97e-2e3e8e36a770" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019d9cbf-bcc1-79ba-89df-4f69afb158a9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019d9cbf-bcc1-7d02-95c6-7ff6bb97e389" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d9cbf-bcc1-73b3-b97e-2e3e8e36a770" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019d9cbf-bcc1-7d02-95c6-7ff6bb97e389" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019d9cbf-bcc1-713c-8d8f-b07367eec95a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d9cbf-bcc1-73b3-b97e-2e3e8e36a770" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019d9cbf-bcc1-713c-8d8f-b07367eec95a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019d9cbf-bcc1-7937-b31f-1c29fb2963d8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d9cbf-bcc1-73b3-b97e-2e3e8e36a770" xlink:to="loc_us-gaap_Liabilities_019d9cbf-bcc1-7937-b31f-1c29fb2963d8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019d9cbf-bcc1-7267-b907-4a97a693cfae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d9cbf-bcc1-73b3-b97e-2e3e8e36a770" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019d9cbf-bcc1-7267-b907-4a97a693cfae" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_019d9cbf-bcc1-7990-b07e-d5923cf4f6ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d9cbf-bcc1-73b3-b97e-2e3e8e36a770" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_019d9cbf-bcc1-7990-b07e-d5923cf4f6ba" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019d9cbf-bcc1-7268-bc3e-47b5af7d5e89" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_019d9cbf-bcc1-7990-b07e-d5923cf4f6ba" xlink:to="loc_us-gaap_CommonStockValue_019d9cbf-bcc1-7268-bc3e-47b5af7d5e89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019d9cbf-bcc1-73f2-83fe-3980d1550a1c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_019d9cbf-bcc1-7990-b07e-d5923cf4f6ba" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019d9cbf-bcc1-73f2-83fe-3980d1550a1c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_019d9cbf-bcc1-7821-a7f8-293b346328e5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_019d9cbf-bcc1-7990-b07e-d5923cf4f6ba" xlink:to="loc_us-gaap_TreasuryStockValue_019d9cbf-bcc1-7821-a7f8-293b346328e5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019d9cbf-bcc1-7637-bb60-2667564ea7f2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_019d9cbf-bcc1-7990-b07e-d5923cf4f6ba" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019d9cbf-bcc1-7637-bb60-2667564ea7f2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019d9cbf-bcc1-7109-b846-6eef97e0dab4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_019d9cbf-bcc1-7990-b07e-d5923cf4f6ba" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019d9cbf-bcc1-7109-b846-6eef97e0dab4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019d9cbf-bcc1-7863-904b-6e4969fb2748" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_019d9cbf-bcc1-7990-b07e-d5923cf4f6ba" xlink:to="loc_us-gaap_StockholdersEquity_019d9cbf-bcc1-7863-904b-6e4969fb2748" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_019d9cbf-bcc1-7148-be25-b5af8c79e8fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MinorityInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_019d9cbf-bcc1-7990-b07e-d5923cf4f6ba" xlink:to="loc_us-gaap_MinorityInterest_019d9cbf-bcc1-7148-be25-b5af8c79e8fb" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019d9cbf-bcc1-7d65-9cc5-2f94082b2d90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAbstract_019d9cbf-bcc1-7990-b07e-d5923cf4f6ba" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019d9cbf-bcc1-7d65-9cc5-2f94082b2d90" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019d9cbf-bcc1-742a-a2d8-1df11294c5da" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d9cbf-bcc1-73b3-b97e-2e3e8e36a770" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_019d9cbf-bcc1-742a-a2d8-1df11294c5da" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="ma-20260331.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-72ea-bd18-e0664979e6c3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019d9cbf-bcc1-70a2-8ea9-76c6c8bd578a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-72ea-bd18-e0664979e6c3" xlink:to="loc_us-gaap_StatementTable_019d9cbf-bcc1-70a2-8ea9-76c6c8bd578a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-75e0-97c0-893611fffd01" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019d9cbf-bcc1-70a2-8ea9-76c6c8bd578a" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-75e0-97c0-893611fffd01" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-75e0-97c0-893611fffd01_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-75e0-97c0-893611fffd01" xlink:to="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-75e0-97c0-893611fffd01_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7adc-8d31-74e3eb00e861" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-75e0-97c0-893611fffd01" xlink:to="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7adc-8d31-74e3eb00e861" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d9cbf-bcc1-7fad-a239-e9c13e711b7c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7adc-8d31-74e3eb00e861" xlink:to="loc_us-gaap_CommonClassAMember_019d9cbf-bcc1-7fad-a239-e9c13e711b7c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019d9cbf-bcc1-7c96-92a9-40753bf63a2b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7adc-8d31-74e3eb00e861" xlink:to="loc_us-gaap_CommonClassBMember_019d9cbf-bcc1-7c96-92a9-40753bf63a2b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019d9cbf-bcc1-7d91-8633-ff4e0d9b86cb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-72ea-bd18-e0664979e6c3" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019d9cbf-bcc1-7d91-8633-ff4e0d9b86cb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019d9cbf-bcc1-702a-a4fc-d64f4c8c6927" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-72ea-bd18-e0664979e6c3" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019d9cbf-bcc1-702a-a4fc-d64f4c8c6927" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_019d9cbf-bcc1-738d-9e9c-6c224f79475f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-72ea-bd18-e0664979e6c3" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_019d9cbf-bcc1-738d-9e9c-6c224f79475f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_019d9cbf-bcc1-7174-8607-2485144c1d31" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-72ea-bd18-e0664979e6c3" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_019d9cbf-bcc1-7174-8607-2485144c1d31" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_019d9cbf-bcc1-7af9-80d3-e91073b2fbad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-72ea-bd18-e0664979e6c3" xlink:to="loc_us-gaap_CommonStockSharesIssued_019d9cbf-bcc1-7af9-80d3-e91073b2fbad" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019d9cbf-bcc1-7d81-8279-c605d69f76b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-72ea-bd18-e0664979e6c3" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019d9cbf-bcc1-7d81-8279-c605d69f76b5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_019d9cbf-bcc1-755a-a197-8a1a8f8e0046" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-72ea-bd18-e0664979e6c3" xlink:to="loc_us-gaap_TreasuryStockCommonShares_019d9cbf-bcc1-755a-a197-8a1a8f8e0046" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/ConsolidatedStatementsofChangesinEquity" xlink:type="simple" xlink:href="ma-20260331.xsd#ConsolidatedStatementsofChangesinEquity"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/ConsolidatedStatementsofChangesinEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-78d7-b483-371ef78d181d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019d9cbf-bcc1-7590-a47c-2561eff29f39" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-78d7-b483-371ef78d181d" xlink:to="loc_us-gaap_StatementTable_019d9cbf-bcc1-7590-a47c-2561eff29f39" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bcc1-7420-9fed-a60c88170342" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019d9cbf-bcc1-7590-a47c-2561eff29f39" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bcc1-7420-9fed-a60c88170342" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-7420-9fed-a60c88170342_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bcc1-7420-9fed-a60c88170342" xlink:to="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-7420-9fed-a60c88170342_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-740f-9ffd-8bd16db87213" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bcc1-7420-9fed-a60c88170342" xlink:to="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-740f-9ffd-8bd16db87213" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019d9cbf-bcc1-709f-8ed0-f8cceebc3d01" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-740f-9ffd-8bd16db87213" xlink:to="loc_us-gaap_CommonStockMember_019d9cbf-bcc1-709f-8ed0-f8cceebc3d01" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019d9cbf-bcc1-79d8-a1ae-5295e202a7a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-740f-9ffd-8bd16db87213" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019d9cbf-bcc1-79d8-a1ae-5295e202a7a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_019d9cbf-bcc1-70c5-b220-a6f53b1f4669" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-740f-9ffd-8bd16db87213" xlink:to="loc_us-gaap_TreasuryStockCommonMember_019d9cbf-bcc1-70c5-b220-a6f53b1f4669" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019d9cbf-bcc1-782a-8358-2977db86c5e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-740f-9ffd-8bd16db87213" xlink:to="loc_us-gaap_RetainedEarningsMember_019d9cbf-bcc1-782a-8358-2977db86c5e7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019d9cbf-bcc1-775e-a2e2-6cb9143406ba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-740f-9ffd-8bd16db87213" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019d9cbf-bcc1-775e-a2e2-6cb9143406ba" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParentMember_019d9cbf-bcc1-7ab5-acc8-9386b586d0b6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-740f-9ffd-8bd16db87213" xlink:to="loc_us-gaap_ParentMember_019d9cbf-bcc1-7ab5-acc8-9386b586d0b6" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_019d9cbf-bcc1-7c4f-944c-9c141532a7a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bcc1-740f-9ffd-8bd16db87213" xlink:to="loc_us-gaap_NoncontrollingInterestMember_019d9cbf-bcc1-7c4f-944c-9c141532a7a0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-7d87-b03b-682e56a5f562" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019d9cbf-bcc1-7590-a47c-2561eff29f39" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-7d87-b03b-682e56a5f562" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7d87-b03b-682e56a5f562_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-7d87-b03b-682e56a5f562" xlink:to="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-7d87-b03b-682e56a5f562_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-78e8-81b6-8cee763f889d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bcc1-7d87-b03b-682e56a5f562" xlink:to="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-78e8-81b6-8cee763f889d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d9cbf-bcc1-730f-aca9-94ba976d154e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-78e8-81b6-8cee763f889d" xlink:to="loc_us-gaap_CommonClassAMember_019d9cbf-bcc1-730f-aca9-94ba976d154e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019d9cbf-bcc1-7486-b7cf-f72b06055b3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bcc1-78e8-81b6-8cee763f889d" xlink:to="loc_us-gaap_CommonClassBMember_019d9cbf-bcc1-7486-b7cf-f72b06055b3d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bcc1-7a9e-b240-8e51808b88cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d9cbf-bcc1-78d7-b483-371ef78d181d" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bcc1-7a9e-b240-8e51808b88cd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019d9cbf-bcc1-7d4e-94a3-6069bbbb4c34" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bcc1-7a9e-b240-8e51808b88cd" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019d9cbf-bcc1-7d4e-94a3-6069bbbb4c34" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019d9cbf-bcc1-7f64-ac0f-aa14c0089476" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bcc1-7a9e-b240-8e51808b88cd" xlink:to="loc_us-gaap_ProfitLoss_019d9cbf-bcc1-7f64-ac0f-aa14c0089476" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019d9cbf-bcc1-7396-8f6e-ea1a915988fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bcc1-7a9e-b240-8e51808b88cd" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_019d9cbf-bcc1-7396-8f6e-ea1a915988fb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019d9cbf-bcc1-7f92-9313-79634262d712" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bcc1-7a9e-b240-8e51808b88cd" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019d9cbf-bcc1-7f92-9313-79634262d712" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_019d9cbf-bcc1-7245-b66b-b4d7bf49c66f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bcc1-7a9e-b240-8e51808b88cd" xlink:to="loc_us-gaap_DividendsCommonStockCash_019d9cbf-bcc1-7245-b66b-b4d7bf49c66f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_TreasuryStockValueAcquiredCostMethodTradeDateBasis_019d9cbf-bcc1-722e-8553-f52460a76546" xlink:href="ma-20260331.xsd#ma_TreasuryStockValueAcquiredCostMethodTradeDateBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bcc1-7a9e-b240-8e51808b88cd" xlink:to="loc_ma_TreasuryStockValueAcquiredCostMethodTradeDateBasis_019d9cbf-bcc1-722e-8553-f52460a76546" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019d9cbf-bcc1-78c0-86d7-4c0b8d5f10cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bcc1-7a9e-b240-8e51808b88cd" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019d9cbf-bcc1-78c0-86d7-4c0b8d5f10cc" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019d9cbf-bcc1-7026-a374-a2b9dd90bcc5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/AcquisitionsNarrativeDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#AcquisitionsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/AcquisitionsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_019d9cbf-bd7c-7e76-aa8b-3f72f7f3bc0f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019d9cbf-bd7c-7846-82f9-acd90c4de87a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d9cbf-bd7c-7e76-aa8b-3f72f7f3bc0f" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019d9cbf-bd7c-7846-82f9-acd90c4de87a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019d9cbf-bd7c-7d18-b326-ff4a389e2a8c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019d9cbf-bd7c-7846-82f9-acd90c4de87a" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019d9cbf-bd7c-7d18-b326-ff4a389e2a8c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019d9cbf-bd7c-7d18-b326-ff4a389e2a8c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019d9cbf-bd7c-7d18-b326-ff4a389e2a8c" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019d9cbf-bd7c-7d18-b326-ff4a389e2a8c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019d9cbf-bd7c-75b6-9e6b-cf90ee87bd2e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019d9cbf-bd7c-7d18-b326-ff4a389e2a8c" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019d9cbf-bd7c-75b6-9e6b-cf90ee87bd2e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_BVNKHoldingsLimitedMember_019d9cbf-bd7c-7955-a5b4-931dc409fafc" xlink:href="ma-20260331.xsd#ma_BVNKHoldingsLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019d9cbf-bd7c-75b6-9e6b-cf90ee87bd2e" xlink:to="loc_ma_BVNKHoldingsLimitedMember_019d9cbf-bd7c-7955-a5b4-931dc409fafc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_019d9cbf-bd7c-7872-8174-cb1a33664375" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019d9cbf-bd7c-7846-82f9-acd90c4de87a" xlink:to="loc_srt_StatementScenarioAxis_019d9cbf-bd7c-7872-8174-cb1a33664375" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_019d9cbf-bd7c-7872-8174-cb1a33664375_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_019d9cbf-bd7c-7872-8174-cb1a33664375" xlink:to="loc_srt_ScenarioUnspecifiedDomain_019d9cbf-bd7c-7872-8174-cb1a33664375_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_019d9cbf-bd7c-7dd7-9b42-e45f8730bd9b" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_019d9cbf-bd7c-7872-8174-cb1a33664375" xlink:to="loc_srt_ScenarioUnspecifiedDomain_019d9cbf-bd7c-7dd7-9b42-e45f8730bd9b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_019d9cbf-bd7c-7b57-9344-ea0a9dbb12a1" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioForecastMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_019d9cbf-bd7c-7dd7-9b42-e45f8730bd9b" xlink:to="loc_srt_ScenarioForecastMember_019d9cbf-bd7c-7b57-9344-ea0a9dbb12a1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_019db76b-86c7-7708-a10c-c2ef052d618e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d9cbf-bd7c-7e76-aa8b-3f72f7f3bc0f" xlink:to="loc_us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired_019db76b-86c7-7708-a10c-c2ef052d618e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019d9cbf-bd7c-7fdd-927a-311ad41b024f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d9cbf-bd7c-7e76-aa8b-3f72f7f3bc0f" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019d9cbf-bd7c-7fdd-927a-311ad41b024f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_019d9cbf-bd7c-7f77-b106-02bd23e90a75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d9cbf-bd7c-7e76-aa8b-3f72f7f3bc0f" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_019d9cbf-bd7c-7f77-b106-02bd23e90a75" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/RevenueDisaggregationofRevenueDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#RevenueDisaggregationofRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/RevenueDisaggregationofRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-702c-b7de-4edc55f25659" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_019d9cbf-bd7c-7207-87f5-732ade4a78e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-702c-b7de-4edc55f25659" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_019d9cbf-bd7c-7207-87f5-732ade4a78e1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019d9cbf-bd7c-7b77-85d7-a747936014fb" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_019d9cbf-bd7c-7207-87f5-732ade4a78e1" xlink:to="loc_srt_ProductOrServiceAxis_019d9cbf-bd7c-7b77-85d7-a747936014fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019d9cbf-bd7c-7b77-85d7-a747936014fb_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019d9cbf-bd7c-7b77-85d7-a747936014fb" xlink:to="loc_srt_ProductsAndServicesDomain_019d9cbf-bd7c-7b77-85d7-a747936014fb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019d9cbf-bd7c-78b5-9bfd-cef9bce422c3" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019d9cbf-bd7c-7b77-85d7-a747936014fb" xlink:to="loc_srt_ProductsAndServicesDomain_019d9cbf-bd7c-78b5-9bfd-cef9bce422c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_PaymentNetworkMember_019d9cbf-bd7c-76f1-96d9-76926236ac51" xlink:href="ma-20260331.xsd#ma_PaymentNetworkMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019d9cbf-bd7c-78b5-9bfd-cef9bce422c3" xlink:to="loc_ma_PaymentNetworkMember_019d9cbf-bd7c-76f1-96d9-76926236ac51" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_ValueAddedServicesAndSolutionsMember_019d9cbf-bd7c-7a40-8ec7-48fbda02e769" xlink:href="ma-20260331.xsd#ma_ValueAddedServicesAndSolutionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019d9cbf-bd7c-78b5-9bfd-cef9bce422c3" xlink:to="loc_ma_ValueAddedServicesAndSolutionsMember_019d9cbf-bd7c-7a40-8ec7-48fbda02e769" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_019d9cbf-bd7c-71d9-9848-3f2343b73b6f" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_019d9cbf-bd7c-7207-87f5-732ade4a78e1" xlink:to="loc_srt_StatementGeographicalAxis_019d9cbf-bd7c-71d9-9848-3f2343b73b6f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019d9cbf-bd7c-71d9-9848-3f2343b73b6f_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_019d9cbf-bd7c-71d9-9848-3f2343b73b6f" xlink:to="loc_srt_SegmentGeographicalDomain_019d9cbf-bd7c-71d9-9848-3f2343b73b6f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019d9cbf-bd7c-7607-9805-2eba0f1c97f9" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_019d9cbf-bd7c-71d9-9848-3f2343b73b6f" xlink:to="loc_srt_SegmentGeographicalDomain_019d9cbf-bd7c-7607-9805-2eba0f1c97f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NorthAmericaMember_019d9cbf-bd7c-7aa0-ad88-db32abbca5b5" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_NorthAmericaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019d9cbf-bd7c-7607-9805-2eba0f1c97f9" xlink:to="loc_srt_NorthAmericaMember_019d9cbf-bd7c-7aa0-ad88-db32abbca5b5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_InternationalMarketsMember_019d9cbf-bd7c-7823-8297-fee75e2dcd8b" xlink:href="ma-20260331.xsd#ma_InternationalMarketsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019d9cbf-bd7c-7607-9805-2eba0f1c97f9" xlink:to="loc_ma_InternationalMarketsMember_019d9cbf-bd7c-7823-8297-fee75e2dcd8b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019d9cbf-bd7c-767a-82b1-93f6b1da8591" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-702c-b7de-4edc55f25659" xlink:to="loc_us-gaap_Revenues_019d9cbf-bd7c-767a-82b1-93f6b1da8591" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/RevenueLocationonBalanceSheetofAmountsRecognizedFromContractsWithCustomersDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#RevenueLocationonBalanceSheetofAmountsRecognizedFromContractsWithCustomersDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/RevenueLocationonBalanceSheetofAmountsRecognizedFromContractsWithCustomersDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-7b5a-884e-f37262dc7287" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_019d9cbf-bd7c-7f2f-8e05-f0cefdc311f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-7b5a-884e-f37262dc7287" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_019d9cbf-bd7c-7f2f-8e05-f0cefdc311f4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019d9cbf-bd7c-7dd1-b2db-a1f5d3dad830" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfFinancialPositionLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_019d9cbf-bd7c-7f2f-8e05-f0cefdc311f4" xlink:to="loc_us-gaap_StatementOfFinancialPositionLocationBalanceAxis_019d9cbf-bd7c-7dd1-b2db-a1f5d3dad830" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNet_019d9cbf-bd7c-7b10-b40f-bf80c5cfaf82" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerAssetNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-7b5a-884e-f37262dc7287" xlink:to="loc_us-gaap_ContractWithCustomerAssetNet_019d9cbf-bd7c-7b10-b40f-bf80c5cfaf82" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_019d9cbf-bd7c-7a8e-afae-1aa6dfefb3be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-7b5a-884e-f37262dc7287" xlink:to="loc_us-gaap_ContractWithCustomerLiability_019d9cbf-bd7c-7a8e-afae-1aa6dfefb3be" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/RevenueLocationonBalanceSheetofAmountsRecognizedFromContractsWithCustomersDetails_1" xlink:type="simple" xlink:href="ma-20260331.xsd#RevenueLocationonBalanceSheetofAmountsRecognizedFromContractsWithCustomersDetails_1"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/RevenueLocationonBalanceSheetofAmountsRecognizedFromContractsWithCustomersDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-7b5a-884e-f37262dc7287" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_019d9cbf-bd7c-7f2f-8e05-f0cefdc311f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-7b5a-884e-f37262dc7287" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_019d9cbf-bd7c-7f2f-8e05-f0cefdc311f4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNet_019d9cbf-bd7c-7b10-b40f-bf80c5cfaf82" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerAssetNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-7b5a-884e-f37262dc7287" xlink:to="loc_us-gaap_ContractWithCustomerAssetNet_019d9cbf-bd7c-7b10-b40f-bf80c5cfaf82" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_019d9cbf-bd7c-7a8e-afae-1aa6dfefb3be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019d9cbf-bd7c-7b5a-884e-f37262dc7287" xlink:to="loc_us-gaap_ContractWithCustomerLiability_019d9cbf-bd7c-7a8e-afae-1aa6dfefb3be" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/InvestmentsEquityInvestmentsDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#InvestmentsEquityInvestmentsDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/InvestmentsEquityInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d9cbf-bd7c-74fd-8bf1-e98fdbec5a09" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d9cbf-bd7c-715f-8361-31ffc4896339" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d9cbf-bd7c-74fd-8bf1-e98fdbec5a09" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d9cbf-bd7c-715f-8361-31ffc4896339" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_019d9cbf-bd7c-7eb7-899b-aab52fe4d028" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d9cbf-bd7c-715f-8361-31ffc4896339" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_019d9cbf-bd7c-7eb7-899b-aab52fe4d028" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_019d9cbf-bd7c-7eb7-899b-aab52fe4d028_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_019d9cbf-bd7c-7eb7-899b-aab52fe4d028" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_019d9cbf-bd7c-7eb7-899b-aab52fe4d028_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_019d9cbf-bd7c-7559-8b15-2fdbcc379703" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_019d9cbf-bd7c-7eb7-899b-aab52fe4d028" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_019d9cbf-bd7c-7559-8b15-2fdbcc379703" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_MarketableSecuritiesMember_019d9cbf-bd7c-7c16-af40-b0014c16968a" xlink:href="ma-20260331.xsd#ma_MarketableSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_019d9cbf-bd7c-7559-8b15-2fdbcc379703" xlink:to="loc_ma_MarketableSecuritiesMember_019d9cbf-bd7c-7c16-af40-b0014c16968a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_NonmarketableSecuritiesMember_019d9cbf-bd7c-778b-9ec2-c7516de2f4e2" xlink:href="ma-20260331.xsd#ma_NonmarketableSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_019d9cbf-bd7c-7559-8b15-2fdbcc379703" xlink:to="loc_ma_NonmarketableSecuritiesMember_019d9cbf-bd7c-778b-9ec2-c7516de2f4e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_019dd480-5baa-7f5a-b2c3-5e6f96b62c1a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d9cbf-bd7c-74fd-8bf1-e98fdbec5a09" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_019dd480-5baa-7f5a-b2c3-5e6f96b62c1a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_EquitySecuritiesFVNIPurchases_019d9cbf-bd7c-76ac-9b37-b615f15cca1d" xlink:href="ma-20260331.xsd#ma_EquitySecuritiesFVNIPurchases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d9cbf-bd7c-74fd-8bf1-e98fdbec5a09" xlink:to="loc_ma_EquitySecuritiesFVNIPurchases_019d9cbf-bd7c-76ac-9b37-b615f15cca1d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_EquitySecuritiesFVNISales_019d9cbf-bd7c-7d08-bf14-57ae9632ba28" xlink:href="ma-20260331.xsd#ma_EquitySecuritiesFVNISales"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d9cbf-bd7c-74fd-8bf1-e98fdbec5a09" xlink:to="loc_ma_EquitySecuritiesFVNISales_019d9cbf-bd7c-7d08-bf14-57ae9632ba28" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_019d9cbf-bd7c-726f-bc65-af5763560a10" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d9cbf-bd7c-74fd-8bf1-e98fdbec5a09" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_019d9cbf-bd7c-726f-bc65-af5763560a10" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_EquitySecuritiesFVNIOtherAdjustments_019d9cbf-bd7c-78a2-9927-9e95e4d10155" xlink:href="ma-20260331.xsd#ma_EquitySecuritiesFVNIOtherAdjustments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d9cbf-bd7c-74fd-8bf1-e98fdbec5a09" xlink:to="loc_ma_EquitySecuritiesFVNIOtherAdjustments_019d9cbf-bd7c-78a2-9927-9e95e4d10155" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_019d9cbf-bd7c-7b01-bea0-57215cf9d847" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/FairValueMeasurementsDistributionofFinancialInstrumentsMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#FairValueMeasurementsDistributionofFinancialInstrumentsMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/FairValueMeasurementsDistributionofFinancialInstrumentsMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019d9cbf-bd7c-76fc-92f5-2d9df9c6a45d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueOptionQuantitativeDisclosuresLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019d9cbf-bd7c-7323-a2c0-ff163f6354c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueOptionQuantitativeDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019d9cbf-bd7c-76fc-92f5-2d9df9c6a45d" xlink:to="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019d9cbf-bd7c-7323-a2c0-ff163f6354c9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-7558-b0d0-60cdb89fde21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019d9cbf-bd7c-7323-a2c0-ff163f6354c9" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-7558-b0d0-60cdb89fde21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7558-b0d0-60cdb89fde21_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-7558-b0d0-60cdb89fde21" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7558-b0d0-60cdb89fde21_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-75eb-87b9-f3047561c122" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-7558-b0d0-60cdb89fde21" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-75eb-87b9-f3047561c122" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019d9cbf-bd7c-75b0-b78c-09ae10f973e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-75eb-87b9-f3047561c122" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019d9cbf-bd7c-75b0-b78c-09ae10f973e3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_019d9cbf-bd7c-7d24-af73-c30678dc232f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-75eb-87b9-f3047561c122" xlink:to="loc_us-gaap_InterestRateContractMember_019d9cbf-bd7c-7d24-af73-c30678dc232f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_019d9cbf-bd7c-769f-b22d-50f4f3f4f5a9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019d9cbf-bd7c-7323-a2c0-ff163f6354c9" xlink:to="loc_us-gaap_FinancialInstrumentAxis_019d9cbf-bd7c-769f-b22d-50f4f3f4f5a9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d9cbf-bd7c-769f-b22d-50f4f3f4f5a9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019d9cbf-bd7c-769f-b22d-50f4f3f4f5a9" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d9cbf-bd7c-769f-b22d-50f4f3f4f5a9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d9cbf-bd7c-714c-a91b-5b550109ba4d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019d9cbf-bd7c-769f-b22d-50f4f3f4f5a9" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d9cbf-bd7c-714c-a91b-5b550109ba4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesMember_019d9cbf-bd7c-7772-90cc-eb1144a8c198" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d9cbf-bd7c-714c-a91b-5b550109ba4d" xlink:to="loc_us-gaap_EquitySecuritiesMember_019d9cbf-bd7c-7772-90cc-eb1144a8c198" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019d9cbf-bd7c-7235-84af-ade46ad5f69c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresTable_019d9cbf-bd7c-7323-a2c0-ff163f6354c9" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019d9cbf-bd7c-7235-84af-ade46ad5f69c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d9cbf-bd7c-7235-84af-ade46ad5f69c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019d9cbf-bd7c-7235-84af-ade46ad5f69c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d9cbf-bd7c-7235-84af-ade46ad5f69c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d9cbf-bd7c-703c-832f-1ceb5c75d3e4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019d9cbf-bd7c-7235-84af-ade46ad5f69c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d9cbf-bd7c-703c-832f-1ceb5c75d3e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019d9cbf-bd7c-7db6-91f3-944090365eee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d9cbf-bd7c-703c-832f-1ceb5c75d3e4" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019d9cbf-bd7c-7db6-91f3-944090365eee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019d9cbf-bd7c-74bf-ba9a-c7a6aa670fad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d9cbf-bd7c-703c-832f-1ceb5c75d3e4" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019d9cbf-bd7c-74bf-ba9a-c7a6aa670fad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019d9cbf-bd7c-7839-ab3a-e323af6ad5e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d9cbf-bd7c-703c-832f-1ceb5c75d3e4" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019d9cbf-bd7c-7839-ab3a-e323af6ad5e8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019d9cbf-bd7c-724f-8725-e92f4bde2a4e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019d9cbf-bd7c-76fc-92f5-2d9df9c6a45d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019d9cbf-bd7c-724f-8725-e92f4bde2a4e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_019d9cbf-bd7c-7961-a0f9-7c7ae7bb88f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019d9cbf-bd7c-76fc-92f5-2d9df9c6a45d" xlink:to="loc_us-gaap_DerivativeAssets_019d9cbf-bd7c-7961-a0f9-7c7ae7bb88f0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_019d9cbf-bd7c-7166-8301-0bd054cb6901" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019d9cbf-bd7c-76fc-92f5-2d9df9c6a45d" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_019d9cbf-bd7c-7166-8301-0bd054cb6901" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_019d9cbf-bd7c-723a-973b-80a03507c251" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueOptionQuantitativeDisclosuresLineItems_019d9cbf-bd7c-76fc-92f5-2d9df9c6a45d" xlink:to="loc_us-gaap_DerivativeLiabilities_019d9cbf-bd7c-723a-973b-80a03507c251" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/FairValueMeasurementsNarrativeFairValueDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#FairValueMeasurementsNarrativeFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/FairValueMeasurementsNarrativeFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019d9cbf-bd7c-7f2e-b3cb-0f667919e594" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019d9cbf-bd7c-7407-9146-049f4a85dc9e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019d9cbf-bd7c-7f2e-b3cb-0f667919e594" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019d9cbf-bd7c-7407-9146-049f4a85dc9e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_019d9cbf-bd7c-74ec-a719-36d8bb736307" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019d9cbf-bd7c-7407-9146-049f4a85dc9e" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_019d9cbf-bd7c-74ec-a719-36d8bb736307" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019d9cbf-bd7c-74ec-a719-36d8bb736307_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_019d9cbf-bd7c-74ec-a719-36d8bb736307" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019d9cbf-bd7c-74ec-a719-36d8bb736307_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019d9cbf-bd7c-7456-81f5-f9464bcd9648" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_019d9cbf-bd7c-74ec-a719-36d8bb736307" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019d9cbf-bd7c-7456-81f5-f9464bcd9648" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019d9cbf-bd7c-7ad9-bbb7-cdc68e2bc0e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019d9cbf-bd7c-7456-81f5-f9464bcd9648" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019d9cbf-bd7c-7ad9-bbb7-cdc68e2bc0e6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_019d9cbf-bd7c-7e09-9763-fda4966d9db0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019d9cbf-bd7c-7ad9-bbb7-cdc68e2bc0e6" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_019d9cbf-bd7c-7e09-9763-fda4966d9db0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019d9cbf-bd7c-7ba9-952e-09889791acc1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019d9cbf-bd7c-7f2e-b3cb-0f667919e594" xlink:to="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019d9cbf-bd7c-7ba9-952e-09889791acc1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_019d9cbf-bd7c-7e9c-990b-c85382707a3e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019d9cbf-bd7c-7f2e-b3cb-0f667919e594" xlink:to="loc_us-gaap_LongTermDebtFairValue_019d9cbf-bd7c-7e9c-990b-c85382707a3e" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/DebtScheduleofLongtermDebtDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#DebtScheduleofLongtermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/DebtScheduleofLongtermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-78e1-9598-d26c69ebcd68" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:to="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-78e1-9598-d26c69ebcd68" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019d9cbf-bd7c-732d-a245-f8bcaed9a7a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-78e1-9598-d26c69ebcd68" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019d9cbf-bd7c-732d-a245-f8bcaed9a7a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019d9cbf-bd7c-732d-a245-f8bcaed9a7a4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019d9cbf-bd7c-732d-a245-f8bcaed9a7a4" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019d9cbf-bd7c-732d-a245-f8bcaed9a7a4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019d9cbf-bd7c-70f6-b9a4-8538c92e94e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019d9cbf-bd7c-732d-a245-f8bcaed9a7a4" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019d9cbf-bd7c-70f6-b9a4-8538c92e94e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_019d9cbf-bd7c-766e-a989-13ab4add73ce" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019d9cbf-bd7c-70f6-b9a4-8538c92e94e1" xlink:to="loc_us-gaap_SeniorNotesMember_019d9cbf-bd7c-766e-a989-13ab4add73ce" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019d9cbf-bd7c-78fa-a0df-ed5a479d5859" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-78e1-9598-d26c69ebcd68" xlink:to="loc_us-gaap_DebtInstrumentAxis_019d9cbf-bd7c-78fa-a0df-ed5a479d5859" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-78fa-a0df-ed5a479d5859_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019d9cbf-bd7c-78fa-a0df-ed5a479d5859" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-78fa-a0df-ed5a479d5859_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019d9cbf-bd7c-78fa-a0df-ed5a479d5859" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_FloatingRateMarch2028NotesMember_019d9cbf-bd7c-7441-a28f-57c211ef2a4f" xlink:href="ma-20260331.xsd#ma_FloatingRateMarch2028NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_FloatingRateMarch2028NotesMember_019d9cbf-bd7c-7441-a28f-57c211ef2a4f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A4.550March2028NotesMember_019d9cbf-bd7c-7c1d-9830-aefe814ce2e3" xlink:href="ma-20260331.xsd#ma_A4.550March2028NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_A4.550March2028NotesMember_019d9cbf-bd7c-7c1d-9830-aefe814ce2e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_March2032NotesMember_019d9cbf-bd7c-7f63-8c78-48f30c2e8d23" xlink:href="ma-20260331.xsd#ma_March2032NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_March2032NotesMember_019d9cbf-bd7c-7f63-8c78-48f30c2e8d23" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_January2028NotesMember_019d9cbf-bd7c-72b3-9b9c-575c7b51b4f6" xlink:href="ma-20260331.xsd#ma_January2028NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_January2028NotesMember_019d9cbf-bd7c-72b3-9b9c-575c7b51b4f6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_January2032NotesMember_019d9cbf-bd7c-78cd-93d5-09886794cac7" xlink:href="ma-20260331.xsd#ma_January2032NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_January2032NotesMember_019d9cbf-bd7c-78cd-93d5-09886794cac7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_January2035NotesMember_019d9cbf-bd7c-7556-bf6e-7423bf28d348" xlink:href="ma-20260331.xsd#ma_January2035NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_January2035NotesMember_019d9cbf-bd7c-7556-bf6e-7423bf28d348" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_May2034NotesMember_019d9cbf-bd7c-761e-9502-4b903f0c422a" xlink:href="ma-20260331.xsd#ma_May2034NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_May2034NotesMember_019d9cbf-bd7c-761e-9502-4b903f0c422a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A4.875March2028NotesMember_019d9cbf-bd7c-72cc-be80-18dfc89e684e" xlink:href="ma-20260331.xsd#ma_A4.875March2028NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_A4.875March2028NotesMember_019d9cbf-bd7c-72cc-be80-18dfc89e684e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_March2033NotesMember_019d9cbf-bd7c-70db-8354-d80740700abc" xlink:href="ma-20260331.xsd#ma_March2033NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_March2033NotesMember_019d9cbf-bd7c-70db-8354-d80740700abc" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_February2029NotesMember_019d9cbf-bd7c-758d-8bbc-0f7b10488a4f" xlink:href="ma-20260331.xsd#ma_February2029NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_February2029NotesMember_019d9cbf-bd7c-758d-8bbc-0f7b10488a4f" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_November2031NotesMember_019d9cbf-bd7c-7d0b-893a-77b647b1f3c2" xlink:href="ma-20260331.xsd#ma_November2031NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_November2031NotesMember_019d9cbf-bd7c-7d0b-893a-77b647b1f3c2" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_March2031NotesMember_019d9cbf-bd7c-7661-88ca-27d9c9150d49" xlink:href="ma-20260331.xsd#ma_March2031NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_March2031NotesMember_019d9cbf-bd7c-7661-88ca-27d9c9150d49" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_March2051NotesMember_019d9cbf-bd7c-74d9-89b6-8bbf8c54f092" xlink:href="ma-20260331.xsd#ma_March2051NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_March2051NotesMember_019d9cbf-bd7c-74d9-89b6-8bbf8c54f092" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A2027NotesMember_019d9cbf-bd7c-7493-8abf-3084acaa2a0b" xlink:href="ma-20260331.xsd#ma_A2027NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_A2027NotesMember_019d9cbf-bd7c-7493-8abf-3084acaa2a0b" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A2030NotesMember_019d9cbf-bd7c-7850-9689-cc93a6d5bd04" xlink:href="ma-20260331.xsd#ma_A2030NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_A2030NotesMember_019d9cbf-bd7c-7850-9689-cc93a6d5bd04" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_March2050NotesMember_019d9cbf-bd7c-7078-8884-f39095ebb1d4" xlink:href="ma-20260331.xsd#ma_March2050NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_March2050NotesMember_019d9cbf-bd7c-7078-8884-f39095ebb1d4" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A2029NotesMember_019d9cbf-bd7c-736f-bf64-69fa5ee896db" xlink:href="ma-20260331.xsd#ma_A2029NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_A2029NotesMember_019d9cbf-bd7c-736f-bf64-69fa5ee896db" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A2049NotesMember_019d9cbf-bd7c-7e15-b8a4-759c75263b49" xlink:href="ma-20260331.xsd#ma_A2049NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_A2049NotesMember_019d9cbf-bd7c-7e15-b8a4-759c75263b49" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A2028NotesMember_019d9cbf-bd7c-751d-b1dd-30696e2a52ae" xlink:href="ma-20260331.xsd#ma_A2028NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_A2028NotesMember_019d9cbf-bd7c-751d-b1dd-30696e2a52ae" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A2048NotesMember_019d9cbf-bd7c-7d00-b7c7-0a9fd6b8bd0b" xlink:href="ma-20260331.xsd#ma_A2048NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_A2048NotesMember_019d9cbf-bd7c-7d00-b7c7-0a9fd6b8bd0b" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A2026NotesMember_019d9cbf-bd7c-70e2-99b6-46954cc16343" xlink:href="ma-20260331.xsd#ma_A2026NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_A2026NotesMember_019d9cbf-bd7c-70e2-99b6-46954cc16343" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A2046NotesMember_019d9cbf-bd7c-79da-b8dd-ac13f5032959" xlink:href="ma-20260331.xsd#ma_A2046NotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_A2046NotesMember_019d9cbf-bd7c-79da-b8dd-ac13f5032959" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_TwoPointOnePercentNotesDue2027Member_019d9cbf-bd7c-783c-8b86-939ec26a97e3" xlink:href="ma-20260331.xsd#ma_TwoPointOnePercentNotesDue2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_TwoPointOnePercentNotesDue2027Member_019d9cbf-bd7c-783c-8b86-939ec26a97e3" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_TwoPointFivePercentNotesDue2030Member_019d9cbf-bd7c-77bf-b6f3-4f5c4a157c59" xlink:href="ma-20260331.xsd#ma_TwoPointFivePercentNotesDue2030Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d9cbf-bd7c-7501-9df3-b374262d5a49" xlink:to="loc_ma_TwoPointFivePercentNotesDue2030Member_019d9cbf-bd7c-77bf-b6f3-4f5c4a157c59" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019d9cbf-bd7c-7bc3-b292-53f3fa9021d7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_019d9cbf-bd7c-7bc3-b292-53f3fa9021d7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019d9cbf-bd7c-7231-ae2a-678c18dfa802" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019d9cbf-bd7c-7231-ae2a-678c18dfa802" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_019d9cbf-bd7c-76d2-aa7c-f0b86585ed60" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_019d9cbf-bd7c-76d2-aa7c-f0b86585ed60" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019d9cbf-bd7c-7017-8bc0-dd6085a3cbd7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019d9cbf-bd7c-7017-8bc0-dd6085a3cbd7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_CumulativeHedgeAccountingFairValueAdjustment_019d9cbf-bd7c-7880-90dc-9080b2d2c029" xlink:href="ma-20260331.xsd#ma_CumulativeHedgeAccountingFairValueAdjustment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:to="loc_ma_CumulativeHedgeAccountingFairValueAdjustment_019d9cbf-bd7c-7880-90dc-9080b2d2c029" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019d9cbf-bd7c-7196-ba84-b127083c0a07" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:to="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_019d9cbf-bd7c-7196-ba84-b127083c0a07" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019d9cbf-bd7c-750f-a094-610590301d33" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:to="loc_us-gaap_LongTermDebtCurrent_019d9cbf-bd7c-750f-a094-610590301d33" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019d9cbf-bd7c-77e3-b14a-b02ea2c8fd91" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019d9cbf-bd7c-77e3-b14a-b02ea2c8fd91" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_019db71e-29a8-7e0f-ba5d-238b2e42bad3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7e44-b644-936aa2fef9ae" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_019db71e-29a8-7e0f-ba5d-238b2e42bad3" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/DebtNarrativeDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#DebtNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/DebtNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7550-bacc-0d823fd44614" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-7803-b411-39bf6fd7a03a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7550-bacc-0d823fd44614" xlink:to="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-7803-b411-39bf6fd7a03a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019db743-d241-76c3-b366-d2e5fd8c848c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-7803-b411-39bf6fd7a03a" xlink:to="loc_us-gaap_DebtInstrumentAxis_019db743-d241-76c3-b366-d2e5fd8c848c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019db743-d241-76c3-b366-d2e5fd8c848c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019db743-d241-76c3-b366-d2e5fd8c848c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019db743-d241-76c3-b366-d2e5fd8c848c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019db743-d241-7a67-a5c9-a4a8ea1602f2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019db743-d241-76c3-b366-d2e5fd8c848c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019db743-d241-7a67-a5c9-a4a8ea1602f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_CommercialPaperProgramMember_019db743-d241-7533-a420-f2e0ae16e9d4" xlink:href="ma-20260331.xsd#ma_CommercialPaperProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019db743-d241-7a67-a5c9-a4a8ea1602f2" xlink:to="loc_ma_CommercialPaperProgramMember_019db743-d241-7533-a420-f2e0ae16e9d4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_CreditFacilityMember_019db743-d241-7e90-8841-ad6f2ce85b33" xlink:href="ma-20260331.xsd#ma_CreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019db743-d241-7a67-a5c9-a4a8ea1602f2" xlink:to="loc_ma_CreditFacilityMember_019db743-d241-7e90-8841-ad6f2ce85b33" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtMember_019dba27-c282-72f2-9674-e8d795447454" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019db743-d241-7a67-a5c9-a4a8ea1602f2" xlink:to="loc_us-gaap_ShortTermDebtMember_019dba27-c282-72f2-9674-e8d795447454" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019db743-d241-751d-9700-ae16345cbf9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-7803-b411-39bf6fd7a03a" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019db743-d241-751d-9700-ae16345cbf9b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019db743-d241-751d-9700-ae16345cbf9b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019db743-d241-751d-9700-ae16345cbf9b" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019db743-d241-751d-9700-ae16345cbf9b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019db743-d241-78b1-ae6b-77ad4301c745" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019db743-d241-751d-9700-ae16345cbf9b" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019db743-d241-78b1-ae6b-77ad4301c745" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_019db743-d241-7881-bd3a-9b788ede8eff" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019db743-d241-78b1-ae6b-77ad4301c745" xlink:to="loc_us-gaap_LineOfCreditMember_019db743-d241-7881-bd3a-9b788ede8eff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019db743-d241-7b55-bc9a-a43ad1622937" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-7803-b411-39bf6fd7a03a" xlink:to="loc_srt_RangeAxis_019db743-d241-7b55-bc9a-a43ad1622937" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019db743-d241-7b55-bc9a-a43ad1622937_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019db743-d241-7b55-bc9a-a43ad1622937" xlink:to="loc_srt_RangeMember_019db743-d241-7b55-bc9a-a43ad1622937_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019db743-d241-7f7f-a9d5-841a1d8c26ad" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019db743-d241-7b55-bc9a-a43ad1622937" xlink:to="loc_srt_RangeMember_019db743-d241-7f7f-a9d5-841a1d8c26ad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019db743-d241-7f66-a513-783c89960fb1" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019db743-d241-7f7f-a9d5-841a1d8c26ad" xlink:to="loc_srt_MaximumMember_019db743-d241-7f66-a513-783c89960fb1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_019db743-d241-761f-b6dd-da98d5f106e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-7803-b411-39bf6fd7a03a" xlink:to="loc_us-gaap_CreditFacilityAxis_019db743-d241-761f-b6dd-da98d5f106e0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_019db743-d241-761f-b6dd-da98d5f106e0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_019db743-d241-761f-b6dd-da98d5f106e0" xlink:to="loc_us-gaap_CreditFacilityDomain_019db743-d241-761f-b6dd-da98d5f106e0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_019db743-d241-7880-8e41-c43942cb336b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_019db743-d241-761f-b6dd-da98d5f106e0" xlink:to="loc_us-gaap_CreditFacilityDomain_019db743-d241-7880-8e41-c43942cb336b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_019db743-d241-7de4-bdbf-2008ca3b9f3b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_019db743-d241-7880-8e41-c43942cb336b" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_019db743-d241-7de4-bdbf-2008ca3b9f3b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_019db743-d241-7e31-bfee-7a99222f77d7" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-7803-b411-39bf6fd7a03a" xlink:to="loc_srt_StatementScenarioAxis_019db743-d241-7e31-bfee-7a99222f77d7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_019db743-d241-7e31-bfee-7a99222f77d7_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_019db743-d241-7e31-bfee-7a99222f77d7" xlink:to="loc_srt_ScenarioUnspecifiedDomain_019db743-d241-7e31-bfee-7a99222f77d7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_019db743-d241-7af4-b350-43359a9cf30a" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_019db743-d241-7e31-bfee-7a99222f77d7" xlink:to="loc_srt_ScenarioUnspecifiedDomain_019db743-d241-7af4-b350-43359a9cf30a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_019db743-d241-7196-9c53-a184ed3ee931" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioForecastMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_019db743-d241-7af4-b350-43359a9cf30a" xlink:to="loc_srt_ScenarioForecastMember_019db743-d241-7196-9c53-a184ed3ee931" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_019dba28-a817-758c-bffb-1cf22669fe00" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-7803-b411-39bf6fd7a03a" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_019dba28-a817-758c-bffb-1cf22669fe00" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019dba28-a817-758c-bffb-1cf22669fe00_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019dba28-a817-758c-bffb-1cf22669fe00" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019dba28-a817-758c-bffb-1cf22669fe00_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019dba28-a817-7b80-903c-3a925bd70888" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019dba28-a817-758c-bffb-1cf22669fe00" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019dba28-a817-7b80-903c-3a925bd70888" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_019dba2f-42d0-77fa-a3a9-5ef744f4aeda" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_019dba28-a817-7b80-903c-3a925bd70888" xlink:to="loc_us-gaap_CommercialPaperMember_019dba2f-42d0-77fa-a3a9-5ef744f4aeda" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_019dba36-e646-713c-aaa0-c3ff4fe7f89b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d9cbf-bd7c-7803-b411-39bf6fd7a03a" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_019dba36-e646-713c-aaa0-c3ff4fe7f89b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019dba36-e646-713c-aaa0-c3ff4fe7f89b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019dba36-e646-713c-aaa0-c3ff4fe7f89b" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019dba36-e646-713c-aaa0-c3ff4fe7f89b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019dba36-e646-706c-97b0-9b0a087a5774" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019dba36-e646-713c-aaa0-c3ff4fe7f89b" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019dba36-e646-706c-97b0-9b0a087a5774" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_019dba3d-7b38-7bf2-8c9a-c7e055e3e3c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_019dba36-e646-706c-97b0-9b0a087a5774" xlink:to="loc_us-gaap_SubsequentEventMember_019dba3d-7b38-7bf2-8c9a-c7e055e3e3c8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_CommercialPaperMaximumBorrowingCapacity_019db743-d241-7696-bc2a-28fb53ab24b2" xlink:href="ma-20260331.xsd#ma_CommercialPaperMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7550-bacc-0d823fd44614" xlink:to="loc_ma_CommercialPaperMaximumBorrowingCapacity_019db743-d241-7696-bc2a-28fb53ab24b2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_019db743-d241-755c-bf4e-cf9994813e81" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7550-bacc-0d823fd44614" xlink:to="loc_us-gaap_DebtInstrumentTerm_019db743-d241-755c-bf4e-cf9994813e81" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityExpirationPeriod_019dd9c3-e67b-79a6-bb53-b3a590072f2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditFacilityExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7550-bacc-0d823fd44614" xlink:to="loc_us-gaap_LineOfCreditFacilityExpirationPeriod_019dd9c3-e67b-79a6-bb53-b3a590072f2d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019db743-d241-7d31-8612-566ca08eb4f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7550-bacc-0d823fd44614" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019db743-d241-7d31-8612-566ca08eb4f6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_019db743-d241-7d0b-ac97-9cbd93bc3b7c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LineOfCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7550-bacc-0d823fd44614" xlink:to="loc_us-gaap_LineOfCredit_019db743-d241-7d0b-ac97-9cbd93bc3b7c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaper_019db743-d241-7439-b454-7b6ee336193e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommercialPaper"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7550-bacc-0d823fd44614" xlink:to="loc_us-gaap_CommercialPaper_019db743-d241-7439-b454-7b6ee336193e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtWeightedAverageInterestRate_019db743-d241-7e8b-b17c-4a8403332f8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtWeightedAverageInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d9cbf-bd7c-7550-bacc-0d823fd44614" xlink:to="loc_us-gaap_DebtWeightedAverageInterestRate_019db743-d241-7e8b-b17c-4a8403332f8a" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/StockholdersEquityDividendsDeclaredDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#StockholdersEquityDividendsDeclaredDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/StockholdersEquityDividendsDeclaredDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableLineItems_019d9cbf-bd7c-7688-a18e-d9d4620a28bb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsPayableLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableTable_019d9cbf-bd7c-7cc1-a0bd-9a9b98b609b1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsPayableTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DividendsPayableLineItems_019d9cbf-bd7c-7688-a18e-d9d4620a28bb" xlink:to="loc_us-gaap_DividendsPayableTable_019d9cbf-bd7c-7cc1-a0bd-9a9b98b609b1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7601-b126-cc4c92781636" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DividendsPayableTable_019d9cbf-bd7c-7cc1-a0bd-9a9b98b609b1" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7601-b126-cc4c92781636" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-7601-b126-cc4c92781636_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7601-b126-cc4c92781636" xlink:to="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-7601-b126-cc4c92781636_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-7205-bc1f-f0dbd1e54f9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7601-b126-cc4c92781636" xlink:to="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-7205-bc1f-f0dbd1e54f9b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019d9cbf-bd7c-74f6-bc72-dbcf5b2c4749" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-7205-bc1f-f0dbd1e54f9b" xlink:to="loc_us-gaap_CommonStockMember_019d9cbf-bd7c-74f6-bc72-dbcf5b2c4749" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019d9cbf-bd7c-7d72-b4a8-f23e144f0162" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-7205-bc1f-f0dbd1e54f9b" xlink:to="loc_us-gaap_RetainedEarningsMember_019d9cbf-bd7c-7d72-b4a8-f23e144f0162" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_019d9cbf-bd7c-74a7-8a31-d21f475e13e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_019d9cbf-bd7c-7688-a18e-d9d4620a28bb" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_019d9cbf-bd7c-74a7-8a31-d21f475e13e1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_019d9cbf-bd7c-7113-81f4-545cf786b0e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DividendsPayableLineItems_019d9cbf-bd7c-7688-a18e-d9d4620a28bb" xlink:to="loc_us-gaap_DividendsCommonStockCash_019d9cbf-bd7c-7113-81f4-545cf786b0e3" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/StockholdersEquityCommonStockSharesActivityDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#StockholdersEquityCommonStockSharesActivityDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/StockholdersEquityCommonStockSharesActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019d9cbf-bd7c-7774-87a5-1be79a50b54d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019d9cbf-bd7c-7142-ae7e-1008878560f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d9cbf-bd7c-7774-87a5-1be79a50b54d" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019d9cbf-bd7c-7142-ae7e-1008878560f7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7d88-9f51-84855db60bb7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019d9cbf-bd7c-7142-ae7e-1008878560f7" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7d88-9f51-84855db60bb7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-7d88-9f51-84855db60bb7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7d88-9f51-84855db60bb7" xlink:to="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-7d88-9f51-84855db60bb7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-731e-9055-884601d57985" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7d88-9f51-84855db60bb7" xlink:to="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-731e-9055-884601d57985" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019d9cbf-bd7c-7066-a450-062d18f3fac7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-731e-9055-884601d57985" xlink:to="loc_us-gaap_CommonStockMember_019d9cbf-bd7c-7066-a450-062d18f3fac7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bd7c-7d78-ac3b-94af7b203643" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019d9cbf-bd7c-7142-ae7e-1008878560f7" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bd7c-7d78-ac3b-94af7b203643" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d9cbf-bd7c-7d78-ac3b-94af7b203643_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bd7c-7d78-ac3b-94af7b203643" xlink:to="loc_us-gaap_ClassOfStockDomain_019d9cbf-bd7c-7d78-ac3b-94af7b203643_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d9cbf-bd7c-7213-8825-b5c75c2b6940" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d9cbf-bd7c-7d78-ac3b-94af7b203643" xlink:to="loc_us-gaap_ClassOfStockDomain_019d9cbf-bd7c-7213-8825-b5c75c2b6940" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d9cbf-bd7c-7f23-9efd-342d9b4d1de4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bd7c-7213-8825-b5c75c2b6940" xlink:to="loc_us-gaap_CommonClassAMember_019d9cbf-bd7c-7f23-9efd-342d9b4d1de4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019d9cbf-bd7c-79b9-996c-4a09bad99287" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d9cbf-bd7c-7213-8825-b5c75c2b6940" xlink:to="loc_us-gaap_CommonClassBMember_019d9cbf-bd7c-79b9-996c-4a09bad99287" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bd7c-75a9-bbf0-b486c983f4a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d9cbf-bd7c-7774-87a5-1be79a50b54d" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bd7c-75a9-bbf0-b486c983f4a2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_019d9cbf-bd7c-7376-b173-60c8ade64353" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bd7c-75a9-bbf0-b486c983f4a2" xlink:to="loc_us-gaap_SharesOutstanding_019d9cbf-bd7c-7376-b173-60c8ade64353" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_019d9cbf-bd7c-7861-bbd0-6f061f5805b0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockSharesAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bd7c-75a9-bbf0-b486c983f4a2" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_019d9cbf-bd7c-7861-bbd0-6f061f5805b0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_AdjustmentstoAdditionalPaidinCapitalSharebasedCompensationRequisiteServicePeriodRecognitionshares_019d9cbf-bd7c-771f-9c67-394d2f4a15cf" xlink:href="ma-20260331.xsd#ma_AdjustmentstoAdditionalPaidinCapitalSharebasedCompensationRequisiteServicePeriodRecognitionshares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bd7c-75a9-bbf0-b486c983f4a2" xlink:to="loc_ma_AdjustmentstoAdditionalPaidinCapitalSharebasedCompensationRequisiteServicePeriodRecognitionshares_019d9cbf-bd7c-771f-9c67-394d2f4a15cf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockSharesConverted1_019d9cbf-bd7c-799c-907c-144f4aee0a3c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConversionOfStockSharesConverted1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d9cbf-bd7c-75a9-bbf0-b486c983f4a2" xlink:to="loc_us-gaap_ConversionOfStockSharesConverted1_019d9cbf-bd7c-799c-907c-144f4aee0a3c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_019d9cbf-bd7c-7c11-aefa-a0fd4fb7ecfb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharesOutstanding"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/StockholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#StockholdersEquityNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/StockholdersEquityNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityClassOfTreasuryStockLineItems_019d9cbf-bd7c-73ee-aa6b-6d8257090b31" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityClassOfTreasuryStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfTreasuryStockTable_019d9cbf-bd7c-7eac-b3cb-c1c6aa54b553" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfTreasuryStockTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_019d9cbf-bd7c-73ee-aa6b-6d8257090b31" xlink:to="loc_us-gaap_ClassOfTreasuryStockTable_019d9cbf-bd7c-7eac-b3cb-c1c6aa54b553" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ShareRepurchaseProgramAxis_019d9cbf-bd7c-715e-b3ec-c429bbbc2875" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ShareRepurchaseProgramAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfTreasuryStockTable_019d9cbf-bd7c-7eac-b3cb-c1c6aa54b553" xlink:to="loc_srt_ShareRepurchaseProgramAxis_019d9cbf-bd7c-715e-b3ec-c429bbbc2875" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ShareRepurchaseProgramDomain_019d9cbf-bd7c-715e-b3ec-c429bbbc2875_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ShareRepurchaseProgramAxis_019d9cbf-bd7c-715e-b3ec-c429bbbc2875" xlink:to="loc_srt_ShareRepurchaseProgramDomain_019d9cbf-bd7c-715e-b3ec-c429bbbc2875_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ShareRepurchaseProgramDomain_019d9cbf-bd7c-7f45-8970-6bc620aa10d4" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ShareRepurchaseProgramAxis_019d9cbf-bd7c-715e-b3ec-c429bbbc2875" xlink:to="loc_srt_ShareRepurchaseProgramDomain_019d9cbf-bd7c-7f45-8970-6bc620aa10d4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_December2022ShareRepurchasePlanMember_019d9cbf-bd7c-741c-bb91-c147481b9b15" xlink:href="ma-20260331.xsd#ma_December2022ShareRepurchasePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ShareRepurchaseProgramDomain_019d9cbf-bd7c-7f45-8970-6bc620aa10d4" xlink:to="loc_ma_December2022ShareRepurchasePlanMember_019d9cbf-bd7c-741c-bb91-c147481b9b15" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_019d9cbf-bd7c-7162-8835-af05c44feda0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfTreasuryStockTable_019d9cbf-bd7c-7eac-b3cb-c1c6aa54b553" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_019d9cbf-bd7c-7162-8835-af05c44feda0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019d9cbf-bd7c-7162-8835-af05c44feda0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019d9cbf-bd7c-7162-8835-af05c44feda0" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019d9cbf-bd7c-7162-8835-af05c44feda0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019d9cbf-bd7c-7ca9-a7cf-2f402ed349bd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019d9cbf-bd7c-7162-8835-af05c44feda0" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019d9cbf-bd7c-7ca9-a7cf-2f402ed349bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_019d9cbf-bd7c-7012-895c-59d03a8c43ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_019d9cbf-bd7c-7ca9-a7cf-2f402ed349bd" xlink:to="loc_us-gaap_SubsequentEventMember_019d9cbf-bd7c-7012-895c-59d03a8c43ec" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StockRepurchaseProgramAuthorizedAmount1_019d9cbf-bd7c-7fcf-8790-a85bea1878f2" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_019d9cbf-bd7c-73ee-aa6b-6d8257090b31" xlink:to="loc_srt_StockRepurchaseProgramAuthorizedAmount1_019d9cbf-bd7c-7fcf-8790-a85bea1878f2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_019d9cbf-bd7c-725d-bfd3-36ffc8278943" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_019d9cbf-bd7c-73ee-aa6b-6d8257090b31" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_019d9cbf-bd7c-725d-bfd3-36ffc8278943" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_019d9cbf-bd7c-7c75-a319-ca7ac76241c9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityClassOfTreasuryStockLineItems_019d9cbf-bd7c-73ee-aa6b-6d8257090b31" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_019d9cbf-bd7c-7c75-a319-ca7ac76241c9" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/AccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#AccumulatedOtherComprehensiveIncomeLossDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/AccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019d9cbf-bd7c-753e-a0a0-13c5dc68db90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019d9cbf-bd7c-7ec3-ada9-753214dea264" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019d9cbf-bd7c-753e-a0a0-13c5dc68db90" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019d9cbf-bd7c-7ec3-ada9-753214dea264" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-71ae-bd05-ca2cac2f5a79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019d9cbf-bd7c-7ec3-ada9-753214dea264" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-71ae-bd05-ca2cac2f5a79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-71ae-bd05-ca2cac2f5a79_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-71ae-bd05-ca2cac2f5a79" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-71ae-bd05-ca2cac2f5a79_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7fca-ab91-7dc1f5728e6b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-71ae-bd05-ca2cac2f5a79" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7fca-ab91-7dc1f5728e6b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019d9cbf-bd7c-7cbe-9fe4-328bcb3c6410" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7fca-ab91-7dc1f5728e6b" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019d9cbf-bd7c-7cbe-9fe4-328bcb3c6410" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_019d9cbf-bd7c-79aa-bd1c-522568a933a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7fca-ab91-7dc1f5728e6b" xlink:to="loc_us-gaap_InterestRateContractMember_019d9cbf-bd7c-79aa-bd1c-522568a933a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7029-a8a7-4c4af69a2bf8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019d9cbf-bd7c-7ec3-ada9-753214dea264" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7029-a8a7-4c4af69a2bf8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-7029-a8a7-4c4af69a2bf8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7029-a8a7-4c4af69a2bf8" xlink:to="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-7029-a8a7-4c4af69a2bf8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-753e-b63e-7e2f472f7986" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019d9cbf-bd7c-7029-a8a7-4c4af69a2bf8" xlink:to="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-753e-b63e-7e2f472f7986" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_019d9cbf-bd7c-7c99-98a5-4d3f7aa86064" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-753e-b63e-7e2f472f7986" xlink:to="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_019d9cbf-bd7c-7c99-98a5-4d3f7aa86064" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_AccumulatedTranslationAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_019d9cbf-bd7c-7911-803b-b7d4f3a77f1b" xlink:href="ma-20260331.xsd#ma_AccumulatedTranslationAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-753e-b63e-7e2f472f7986" xlink:to="loc_ma_AccumulatedTranslationAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_019d9cbf-bd7c-7911-803b-b7d4f3a77f1b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_019d9cbf-bd7c-79da-bd88-163352cd9d0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-753e-b63e-7e2f472f7986" xlink:to="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_019d9cbf-bd7c-79da-bd88-163352cd9d0b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_019d9cbf-bd7c-75c2-a8d0-1d0fadbb956b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-753e-b63e-7e2f472f7986" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_019d9cbf-bd7c-75c2-a8d0-1d0fadbb956b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_019d9cbf-bd7c-73b3-9b44-dcb11b7ffce6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-753e-b63e-7e2f472f7986" xlink:to="loc_us-gaap_AccumulatedNetInvestmentGainLossIncludingPortionAttributableToNoncontrollingInterestMember_019d9cbf-bd7c-73b3-9b44-dcb11b7ffce6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_019d9cbf-bd7c-73fd-baff-edd2db19cdbd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d9cbf-bd7c-753e-b63e-7e2f472f7986" xlink:to="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_019d9cbf-bd7c-73fd-baff-edd2db19cdbd" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019d9cbf-bd7c-7645-b59f-195c8d9950a4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AOCIAttributableToParentNetOfTaxRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019d9cbf-bd7c-753e-a0a0-13c5dc68db90" xlink:to="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019d9cbf-bd7c-7645-b59f-195c8d9950a4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019d9cbf-bd7c-76cc-85ac-1368f53a8855" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019d9cbf-bd7c-7645-b59f-195c8d9950a4" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019d9cbf-bd7c-76cc-85ac-1368f53a8855" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_019d9cbf-bd7c-79e8-8637-22ae6f93e1af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019d9cbf-bd7c-7645-b59f-195c8d9950a4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_019d9cbf-bd7c-79e8-8637-22ae6f93e1af" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_019d9cbf-bd7c-7b86-83a1-9d1f01ac329d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019d9cbf-bd7c-7645-b59f-195c8d9950a4" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_019d9cbf-bd7c-7b86-83a1-9d1f01ac329d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019d9cbf-bd7c-7365-a300-7217ddfd23a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/ShareBasedPaymentsTypesofEquityAwardsDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#ShareBasedPaymentsTypesofEquityAwardsDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/ShareBasedPaymentsTypesofEquityAwardsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-797d-857c-95f1dbbb39c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d9cbf-bd7c-77d9-b1ba-604bca38110a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-797d-857c-95f1dbbb39c5" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d9cbf-bd7c-77d9-b1ba-604bca38110a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019d9cbf-bd7c-7d89-a78a-10dd74b45af9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d9cbf-bd7c-77d9-b1ba-604bca38110a" xlink:to="loc_us-gaap_AwardTypeAxis_019d9cbf-bd7c-7d89-a78a-10dd74b45af9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-7d89-a78a-10dd74b45af9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019d9cbf-bd7c-7d89-a78a-10dd74b45af9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-7d89-a78a-10dd74b45af9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-791d-bcf9-d6226b4481af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019d9cbf-bd7c-7d89-a78a-10dd74b45af9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-791d-bcf9-d6226b4481af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019dd548-dace-71bd-8112-8326a1b2eb81" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-791d-bcf9-d6226b4481af" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019dd548-dace-71bd-8112-8326a1b2eb81" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019d9cbf-bd7c-7908-9063-f5ccf4cfd075" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-791d-bcf9-d6226b4481af" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019d9cbf-bd7c-7908-9063-f5ccf4cfd075" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_019d9cbf-bd7c-78a9-82de-24dc616e2a32" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-791d-bcf9-d6226b4481af" xlink:to="loc_us-gaap_PerformanceSharesMember_019d9cbf-bd7c-78a9-82de-24dc616e2a32" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019d9cbf-bd7c-7a14-9533-c16a45dce8e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-797d-857c-95f1dbbb39c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019d9cbf-bd7c-7a14-9533-c16a45dce8e2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019d9cbf-bd7c-74a4-b0cc-2676a4fe04c3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-797d-857c-95f1dbbb39c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019d9cbf-bd7c-74a4-b0cc-2676a4fe04c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019d9cbf-bd7c-717f-9abf-cbc2360baec4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-797d-857c-95f1dbbb39c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019d9cbf-bd7c-717f-9abf-cbc2360baec4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019d9cbf-bd7c-753d-b65a-0edd1599b74f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-797d-857c-95f1dbbb39c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019d9cbf-bd7c-753d-b65a-0edd1599b74f" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/ShareBasedPaymentsNarrativeDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#ShareBasedPaymentsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/ShareBasedPaymentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-761f-aef0-6a75a5b3ed07" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d9cbf-bd7c-708f-bba9-976fad3c4d81" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-761f-aef0-6a75a5b3ed07" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d9cbf-bd7c-708f-bba9-976fad3c4d81" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019d9cbf-bd7c-71f7-bc0f-8d31670e41bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d9cbf-bd7c-708f-bba9-976fad3c4d81" xlink:to="loc_us-gaap_AwardTypeAxis_019d9cbf-bd7c-71f7-bc0f-8d31670e41bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-71f7-bc0f-8d31670e41bc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019d9cbf-bd7c-71f7-bc0f-8d31670e41bc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-71f7-bc0f-8d31670e41bc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-7df7-9b13-d5f873ee6736" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019d9cbf-bd7c-71f7-bc0f-8d31670e41bc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-7df7-9b13-d5f873ee6736" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019d9cbf-bd7c-792b-aead-64aca6e39eae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-7df7-9b13-d5f873ee6736" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019d9cbf-bd7c-792b-aead-64aca6e39eae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_RestrictedStockUnitsRSUsGrantedOnOrAfterMarch12020Member_019d9cbf-bd7c-704f-ac92-314e5795deda" xlink:href="ma-20260331.xsd#ma_RestrictedStockUnitsRSUsGrantedOnOrAfterMarch12020Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-7df7-9b13-d5f873ee6736" xlink:to="loc_ma_RestrictedStockUnitsRSUsGrantedOnOrAfterMarch12020Member_019d9cbf-bd7c-704f-ac92-314e5795deda" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_019d9cbf-bd7c-775a-8a2f-0d86c3a447b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9cbf-bd7c-7df7-9b13-d5f873ee6736" xlink:to="loc_us-gaap_PerformanceSharesMember_019d9cbf-bd7c-775a-8a2f-0d86c3a447b8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_019d9cbf-bd7c-713e-816c-9d126d6bc963" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-761f-aef0-6a75a5b3ed07" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_019d9cbf-bd7c-713e-816c-9d126d6bc963" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_019d9cbf-bd7c-7944-974d-419ddff1b512" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-761f-aef0-6a75a5b3ed07" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_019d9cbf-bd7c-7944-974d-419ddff1b512" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_019d9cbf-bd7c-7011-a606-67183a6a2fe3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-761f-aef0-6a75a5b3ed07" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_019d9cbf-bd7c-7011-a606-67183a6a2fe3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019d9cbf-bd7c-7a56-a2fa-7b97ea5cf923" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-761f-aef0-6a75a5b3ed07" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019d9cbf-bd7c-7a56-a2fa-7b97ea5cf923" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuableUponVestingMandatoryDeferralPeriod_019d9cbf-bd7c-7e6a-b81e-bb574f023f6e" xlink:href="ma-20260331.xsd#ma_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuableUponVestingMandatoryDeferralPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9cbf-bd7c-761f-aef0-6a75a5b3ed07" xlink:to="loc_ma_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuableUponVestingMandatoryDeferralPeriod_019d9cbf-bd7c-7e6a-b81e-bb574f023f6e" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/LegalandRegulatoryProceedingsDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#LegalandRegulatoryProceedingsDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/LegalandRegulatoryProceedingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:href="ma-20260331.xsd#ma_LegalAndRegulatoryLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_LegalAndRegulatoryProceedingsTable_019d9cbf-bd7c-77b5-a4d2-51c974c10af7" xlink:href="ma-20260331.xsd#ma_LegalAndRegulatoryProceedingsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_ma_LegalAndRegulatoryProceedingsTable_019d9cbf-bd7c-77b5-a4d2-51c974c10af7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_019d9cbf-bd7c-7fa6-83ce-6602726f77f1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ma_LegalAndRegulatoryProceedingsTable_019d9cbf-bd7c-77b5-a4d2-51c974c10af7" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_019d9cbf-bd7c-7fa6-83ce-6602726f77f1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_019d9cbf-bd7c-7fa6-83ce-6602726f77f1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_019d9cbf-bd7c-7fa6-83ce-6602726f77f1" xlink:to="loc_us-gaap_LossContingencyNatureDomain_019d9cbf-bd7c-7fa6-83ce-6602726f77f1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_019d9cbf-bd7c-7b50-b846-4598057308d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_019d9cbf-bd7c-7fa6-83ce-6602726f77f1" xlink:to="loc_us-gaap_LossContingencyNatureDomain_019d9cbf-bd7c-7b50-b846-4598057308d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_EventInvolvingVisaPartiesMemberBanksAndMastercardMember_019d9cbf-bd7c-7e18-8dfa-3b4b742e4b90" xlink:href="ma-20260331.xsd#ma_EventInvolvingVisaPartiesMemberBanksAndMastercardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_019d9cbf-bd7c-7b50-b846-4598057308d5" xlink:to="loc_ma_EventInvolvingVisaPartiesMemberBanksAndMastercardMember_019d9cbf-bd7c-7e18-8dfa-3b4b742e4b90" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_EventInvolvingMemberBanksAndMastercardMember_019d9cbf-bd7c-72ee-a5df-323e573871aa" xlink:href="ma-20260331.xsd#ma_EventInvolvingMemberBanksAndMastercardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_019d9cbf-bd7c-7b50-b846-4598057308d5" xlink:to="loc_ma_EventInvolvingMemberBanksAndMastercardMember_019d9cbf-bd7c-72ee-a5df-323e573871aa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_U.S.MerchantLitigationClassLitigationMember_019d9cbf-bd7c-72d9-846f-11481bba502b" xlink:href="ma-20260331.xsd#ma_U.S.MerchantLitigationClassLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_019d9cbf-bd7c-7b50-b846-4598057308d5" xlink:to="loc_ma_U.S.MerchantLitigationClassLitigationMember_019d9cbf-bd7c-72d9-846f-11481bba502b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_USMerchantLawsuitSettlementMember_019d9cbf-bd7c-7b7f-b7df-8acb6a608724" xlink:href="ma-20260331.xsd#ma_USMerchantLawsuitSettlementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_019d9cbf-bd7c-7b50-b846-4598057308d5" xlink:to="loc_ma_USMerchantLawsuitSettlementMember_019d9cbf-bd7c-7b7f-b7df-8acb6a608724" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_U.S.MerchantLitigationClassLitigationBlockAndIntuitMember_019d9cbf-bd7c-7cc7-962b-ee7fcbeca38f" xlink:href="ma-20260331.xsd#ma_U.S.MerchantLitigationClassLitigationBlockAndIntuitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_019d9cbf-bd7c-7b50-b846-4598057308d5" xlink:to="loc_ma_U.S.MerchantLitigationClassLitigationBlockAndIntuitMember_019d9cbf-bd7c-7cc7-962b-ee7fcbeca38f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019d9cbf-bd7c-7e4a-b584-37c08744e032" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ma_LegalAndRegulatoryProceedingsTable_019d9cbf-bd7c-77b5-a4d2-51c974c10af7" xlink:to="loc_srt_RangeAxis_019d9cbf-bd7c-7e4a-b584-37c08744e032" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019d9cbf-bd7c-7e4a-b584-37c08744e032_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019d9cbf-bd7c-7e4a-b584-37c08744e032" xlink:to="loc_srt_RangeMember_019d9cbf-bd7c-7e4a-b584-37c08744e032_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019d9cbf-bd7c-7f4a-952d-dac2b66a13e6" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019d9cbf-bd7c-7e4a-b584-37c08744e032" xlink:to="loc_srt_RangeMember_019d9cbf-bd7c-7f4a-952d-dac2b66a13e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019d9cbf-bd7c-70d6-b321-767534850011" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019d9cbf-bd7c-7f4a-952d-dac2b66a13e6" xlink:to="loc_srt_MaximumMember_019d9cbf-bd7c-70d6-b321-767534850011" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019d9cbf-bd7c-7a7a-8cb2-15e9d3390b5a" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019d9cbf-bd7c-7f4a-952d-dac2b66a13e6" xlink:to="loc_srt_MinimumMember_019d9cbf-bd7c-7a7a-8cb2-15e9d3390b5a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusAxis_019d9cbf-bd7c-702c-842d-34d79060e182" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationStatusAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ma_LegalAndRegulatoryProceedingsTable_019d9cbf-bd7c-77b5-a4d2-51c974c10af7" xlink:to="loc_us-gaap_LitigationStatusAxis_019d9cbf-bd7c-702c-842d-34d79060e182" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusDomain_019d9cbf-bd7c-702c-842d-34d79060e182_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LitigationStatusAxis_019d9cbf-bd7c-702c-842d-34d79060e182" xlink:to="loc_us-gaap_LitigationStatusDomain_019d9cbf-bd7c-702c-842d-34d79060e182_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusDomain_019d9cbf-bd7c-78ff-9828-6cede17d24bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LitigationStatusAxis_019d9cbf-bd7c-702c-842d-34d79060e182" xlink:to="loc_us-gaap_LitigationStatusDomain_019d9cbf-bd7c-78ff-9828-6cede17d24bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PendingLitigationMember_019d9cbf-bd7c-73b3-9538-8ef90e8e22c3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PendingLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationStatusDomain_019d9cbf-bd7c-78ff-9828-6cede17d24bc" xlink:to="loc_us-gaap_PendingLitigationMember_019d9cbf-bd7c-73b3-9538-8ef90e8e22c3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_019d9cbf-bd7c-7a9d-9914-bcce99b07a77" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ma_LegalAndRegulatoryProceedingsTable_019d9cbf-bd7c-77b5-a4d2-51c974c10af7" xlink:to="loc_srt_LitigationCaseAxis_019d9cbf-bd7c-7a9d-9914-bcce99b07a77" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7a9d-9914-bcce99b07a77_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_019d9cbf-bd7c-7a9d-9914-bcce99b07a77" xlink:to="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7a9d-9914-bcce99b07a77_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7858-8eef-6d362c2eaf36" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_019d9cbf-bd7c-7a9d-9914-bcce99b07a77" xlink:to="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7858-8eef-6d362c2eaf36" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_U.K.MerchantLawsuitSettlementMember_019d9cbf-bd7c-794b-ae55-790f81a9a3b9" xlink:href="ma-20260331.xsd#ma_U.K.MerchantLawsuitSettlementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7858-8eef-6d362c2eaf36" xlink:to="loc_ma_U.K.MerchantLawsuitSettlementMember_019d9cbf-bd7c-794b-ae55-790f81a9a3b9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_A2022MastercardAndVisaProposedCollectiveActionComplaintInTheUKMember_019d9cbf-bd7c-7006-aba6-1254726c65a4" xlink:href="ma-20260331.xsd#ma_A2022MastercardAndVisaProposedCollectiveActionComplaintInTheUKMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7858-8eef-6d362c2eaf36" xlink:to="loc_ma_A2022MastercardAndVisaProposedCollectiveActionComplaintInTheUKMember_019d9cbf-bd7c-7006-aba6-1254726c65a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_PortugalProposedInterchangeCollectiveActionMember_019d9cbf-bd7c-7e4f-aa3b-00957643b3d0" xlink:href="ma-20260331.xsd#ma_PortugalProposedInterchangeCollectiveActionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7858-8eef-6d362c2eaf36" xlink:to="loc_ma_PortugalProposedInterchangeCollectiveActionMember_019d9cbf-bd7c-7e4f-aa3b-00957643b3d0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_NetherlandsProposedInterchangeCollectiveActionMember_019d9cbf-bd7c-75b1-a63e-15d11668e8d4" xlink:href="ma-20260331.xsd#ma_NetherlandsProposedInterchangeCollectiveActionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7858-8eef-6d362c2eaf36" xlink:to="loc_ma_NetherlandsProposedInterchangeCollectiveActionMember_019d9cbf-bd7c-75b1-a63e-15d11668e8d4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_ATMOperatorsComplaintMember_019d9cbf-bd7c-7783-9a1a-9433c3f28d57" xlink:href="ma-20260331.xsd#ma_ATMOperatorsComplaintMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7858-8eef-6d362c2eaf36" xlink:to="loc_ma_ATMOperatorsComplaintMember_019d9cbf-bd7c-7783-9a1a-9433c3f28d57" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_USLiabilityShiftLitigationMember_019d9cbf-bd7c-740b-8ae4-b3e431c68b6c" xlink:href="ma-20260331.xsd#ma_USLiabilityShiftLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7858-8eef-6d362c2eaf36" xlink:to="loc_ma_USLiabilityShiftLitigationMember_019d9cbf-bd7c-740b-8ae4-b3e431c68b6c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_NonBankATMConsumerClassComplaintMember_019d9cbf-bd7c-77b8-991b-b5be19f3a060" xlink:href="ma-20260331.xsd#ma_NonBankATMConsumerClassComplaintMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_019d9cbf-bd7c-7858-8eef-6d362c2eaf36" xlink:to="loc_ma_NonBankATMConsumerClassComplaintMember_019d9cbf-bd7c-77b8-991b-b5be19f3a060" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_PercentOfSettlementReportingEntityWouldPay_019d9cbf-bd7c-70bb-a8d1-1a35f2f7c151" xlink:href="ma-20260331.xsd#ma_PercentOfSettlementReportingEntityWouldPay"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_ma_PercentOfSettlementReportingEntityWouldPay_019d9cbf-bd7c-70bb-a8d1-1a35f2f7c151" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_PercentageOfOptOutMerchantsToTerminate_019d9cbf-bd7c-7e12-aceb-096b4a900efc" xlink:href="ma-20260331.xsd#ma_PercentageOfOptOutMerchantsToTerminate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_ma_PercentageOfOptOutMerchantsToTerminate_019d9cbf-bd7c-7e12-aceb-096b4a900efc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_PercentageOfMastercardsU.S.InterchangeVolumeRepresentedByOptOutMerchantAndDamagesClassSettlements_019d9cbf-bd7c-79d9-9067-53e839aa1e8c" xlink:href="ma-20260331.xsd#ma_PercentageOfMastercardsU.S.InterchangeVolumeRepresentedByOptOutMerchantAndDamagesClassSettlements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_ma_PercentageOfMastercardsU.S.InterchangeVolumeRepresentedByOptOutMerchantAndDamagesClassSettlements_019d9cbf-bd7c-79d9-9067-53e839aa1e8c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyEstimateOfPossibleLoss_019d9cbf-bd7c-799e-b4f6-005f37150289" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyEstimateOfPossibleLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_us-gaap_LossContingencyEstimateOfPossibleLoss_019d9cbf-bd7c-799e-b4f6-005f37150289" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_LossContingencyPendingClaimsNumberOfClaimsScheduledForTrial_019d9cbf-bd7c-751f-9f2d-a541720abaf5" xlink:href="ma-20260331.xsd#ma_LossContingencyPendingClaimsNumberOfClaimsScheduledForTrial"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_ma_LossContingencyPendingClaimsNumberOfClaimsScheduledForTrial_019d9cbf-bd7c-751f-9f2d-a541720abaf5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_019d9cbf-bd7c-7935-a277-b72e91861e68" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_us-gaap_LitigationReserveCurrent_019d9cbf-bd7c-7935-a277-b72e91861e68" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDamagesSoughtValue_019d9cbf-bd7c-7fd1-b07d-094b16db578d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyDamagesSoughtValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_us-gaap_LossContingencyDamagesSoughtValue_019d9cbf-bd7c-7fd1-b07d-094b16db578d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_019d9cbf-bd7c-71ca-8602-c8b98c1e4e8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_019d9cbf-bd7c-71ca-8602-c8b98c1e4e8a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNumberOfPlaintiffs_019d9cbf-bd7c-77e0-bfd6-7555d1bd8bda" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyNumberOfPlaintiffs"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_us-gaap_LossContingencyNumberOfPlaintiffs_019d9cbf-bd7c-77e0-bfd6-7555d1bd8bda" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNumberOfDefendants_019d9cbf-bd7c-7956-a529-2c5d2e24c3de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyNumberOfDefendants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_us-gaap_LossContingencyNumberOfDefendants_019d9cbf-bd7c-7956-a529-2c5d2e24c3de" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_LossContingencyUnsolicitedAdvertisements_019d9cbf-bd7c-755f-915e-01e49f765287" xlink:href="ma-20260331.xsd#ma_LossContingencyUnsolicitedAdvertisements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_ma_LossContingencyUnsolicitedAdvertisements_019d9cbf-bd7c-755f-915e-01e49f765287" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_LossContingencyDamagesSoughtPerClaim_019d9cbf-bd7c-703e-8eaf-54ba4503a2d1" xlink:href="ma-20260331.xsd#ma_LossContingencyDamagesSoughtPerClaim"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_ma_LossContingencyDamagesSoughtPerClaim_019d9cbf-bd7c-703e-8eaf-54ba4503a2d1" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_LossContingencyPendingClaimsGroupsOfOptOutMerchantsNumber_019d9cbf-bd7c-7926-8595-4989292c5e90" xlink:href="ma-20260331.xsd#ma_LossContingencyPendingClaimsGroupsOfOptOutMerchantsNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_ma_LossContingencyPendingClaimsGroupsOfOptOutMerchantsNumber_019d9cbf-bd7c-7926-8595-4989292c5e90" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_LossContingencyDamagesSoughtComplaintPeriod_019d9cbf-bd7c-7f41-8a1c-a39e57dae970" xlink:href="ma-20260331.xsd#ma_LossContingencyDamagesSoughtComplaintPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_ma_LossContingencyDamagesSoughtComplaintPeriod_019d9cbf-bd7c-7f41-8a1c-a39e57dae970" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_LossContingencyPendingClaimsExcludedMerchantsNumber_019d9cbf-bd7c-754e-82de-86f3098f6b63" xlink:href="ma-20260331.xsd#ma_LossContingencyPendingClaimsExcludedMerchantsNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_ma_LossContingencyPendingClaimsExcludedMerchantsNumber_019d9cbf-bd7c-754e-82de-86f3098f6b63" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyPendingClaimsNumber_019d9cbf-bd7c-7e26-be7b-e6fdaa93d0dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyPendingClaimsNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ma_LegalAndRegulatoryLineItems_019d9cbf-bd7c-72d3-8bbd-9e0123756aa4" xlink:to="loc_us-gaap_LossContingencyPendingClaimsNumber_019d9cbf-bd7c-7e26-be7b-e6fdaa93d0dc" xlink:type="arc" order="15"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/SettlementandOtherRiskManagementEstimatedSettlementExposureDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#SettlementandOtherRiskManagementEstimatedSettlementExposureDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/SettlementandOtherRiskManagementEstimatedSettlementExposureDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RisksInherentInServicingAssetsAndServicingLiabilitiesLineItems_019d9cbf-bd7c-79a5-943d-01216417a09a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RisksInherentInServicingAssetsAndServicingLiabilitiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ManagingOfRisksInherentInServicingAssetsAndServicingLiabilitiesTable_019d9cbf-bd7c-7376-b3a8-126d28600bf9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ManagingOfRisksInherentInServicingAssetsAndServicingLiabilitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RisksInherentInServicingAssetsAndServicingLiabilitiesLineItems_019d9cbf-bd7c-79a5-943d-01216417a09a" xlink:to="loc_us-gaap_ManagingOfRisksInherentInServicingAssetsAndServicingLiabilitiesTable_019d9cbf-bd7c-7376-b3a8-126d28600bf9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GuaranteeObligationsByNatureAxis_019d9cbf-bd7c-75a4-9b43-07d5c263c820" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GuaranteeObligationsByNatureAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ManagingOfRisksInherentInServicingAssetsAndServicingLiabilitiesTable_019d9cbf-bd7c-7376-b3a8-126d28600bf9" xlink:to="loc_us-gaap_GuaranteeObligationsByNatureAxis_019d9cbf-bd7c-75a4-9b43-07d5c263c820" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GuaranteeObligationsNatureDomain_019d9cbf-bd7c-75a4-9b43-07d5c263c820_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GuaranteeObligationsNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_GuaranteeObligationsByNatureAxis_019d9cbf-bd7c-75a4-9b43-07d5c263c820" xlink:to="loc_us-gaap_GuaranteeObligationsNatureDomain_019d9cbf-bd7c-75a4-9b43-07d5c263c820_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GuaranteeObligationsNatureDomain_019d9cbf-bd7c-783d-8c52-8005a32fde8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GuaranteeObligationsNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_GuaranteeObligationsByNatureAxis_019d9cbf-bd7c-75a4-9b43-07d5c263c820" xlink:to="loc_us-gaap_GuaranteeObligationsNatureDomain_019d9cbf-bd7c-783d-8c52-8005a32fde8f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GuaranteeObligationsMember_019d9cbf-bd7c-704a-8f48-359bb89613db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GuaranteeObligationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GuaranteeObligationsNatureDomain_019d9cbf-bd7c-783d-8c52-8005a32fde8f" xlink:to="loc_us-gaap_GuaranteeObligationsMember_019d9cbf-bd7c-704a-8f48-359bb89613db" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_GrossSettlementExposure_019d9cbf-bd7c-7e2c-a0ee-500fbf61600f" xlink:href="ma-20260331.xsd#ma_GrossSettlementExposure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RisksInherentInServicingAssetsAndServicingLiabilitiesLineItems_019d9cbf-bd7c-79a5-943d-01216417a09a" xlink:to="loc_ma_GrossSettlementExposure_019d9cbf-bd7c-7e2c-a0ee-500fbf61600f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_CollateralHeldForSettlementExposure_019d9cbf-bd7c-7cfe-97bf-b267b14225c0" xlink:href="ma-20260331.xsd#ma_CollateralHeldForSettlementExposure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RisksInherentInServicingAssetsAndServicingLiabilitiesLineItems_019d9cbf-bd7c-79a5-943d-01216417a09a" xlink:to="loc_ma_CollateralHeldForSettlementExposure_019d9cbf-bd7c-7cfe-97bf-b267b14225c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_NetUncollateralizedSettlementExposure_019d9cbf-bd7c-76e9-9325-06965c68dac5" xlink:href="ma-20260331.xsd#ma_NetUncollateralizedSettlementExposure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RisksInherentInServicingAssetsAndServicingLiabilitiesLineItems_019d9cbf-bd7c-79a5-943d-01216417a09a" xlink:to="loc_ma_NetUncollateralizedSettlementExposure_019d9cbf-bd7c-76e9-9325-06965c68dac5" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/DerivativeandHedgingInstrumentsNarrativeDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#DerivativeandHedgingInstrumentsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/DerivativeandHedgingInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_019db75b-9944-79ec-9c63-925f0018f2d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_019db75b-9944-70e3-983d-8c78529ff9e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_019db75b-9944-79ec-9c63-925f0018f2d4" xlink:to="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_019db75b-9944-70e3-983d-8c78529ff9e3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019db75b-9944-743d-994d-007463b71152" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_019db75b-9944-70e3-983d-8c78529ff9e3" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019db75b-9944-743d-994d-007463b71152" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_019db75b-9944-743d-994d-007463b71152_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019db75b-9944-743d-994d-007463b71152" xlink:to="loc_us-gaap_HedgingRelationshipDomain_019db75b-9944-743d-994d-007463b71152_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_019db75b-9944-737c-ae3c-ee4a5d8071f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019db75b-9944-743d-994d-007463b71152" xlink:to="loc_us-gaap_HedgingRelationshipDomain_019db75b-9944-737c-ae3c-ee4a5d8071f5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_019db75b-9944-7671-abf8-7a59f73917e7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019db75b-9944-737c-ae3c-ee4a5d8071f5" xlink:to="loc_us-gaap_CashFlowHedgingMember_019db75b-9944-7671-abf8-7a59f73917e7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_019db75b-d5d5-714e-acd2-3b11035396ec" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019db75b-9944-737c-ae3c-ee4a5d8071f5" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_019db75b-d5d5-714e-acd2-3b11035396ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019db75b-d5d5-76c6-ab78-9479f598af05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_019db75b-9944-70e3-983d-8c78529ff9e3" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019db75b-d5d5-76c6-ab78-9479f598af05" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019db75b-d5d5-76c6-ab78-9479f598af05_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019db75b-d5d5-76c6-ab78-9479f598af05" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019db75b-d5d5-76c6-ab78-9479f598af05_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019db75b-d5d6-7aee-aa49-d9d8efca1c13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019db75b-d5d5-76c6-ab78-9479f598af05" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019db75b-d5d6-7aee-aa49-d9d8efca1c13" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_EuroDenominatedDebtMember_019db75b-d5d6-747a-9e2b-22640b3092cc" xlink:href="ma-20260331.xsd#ma_EuroDenominatedDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019db75b-d5d6-7aee-aa49-d9d8efca1c13" xlink:to="loc_ma_EuroDenominatedDebtMember_019db75b-d5d6-747a-9e2b-22640b3092cc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTermOfContract_019db75b-9944-7136-bf4d-37ae823b2e85" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_019db75b-9944-79ec-9c63-925f0018f2d4" xlink:to="loc_us-gaap_DerivativeTermOfContract_019db75b-9944-7136-bf4d-37ae823b2e85" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_019db75b-9944-7651-b055-826c87e89d72" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_019db75b-9944-79ec-9c63-925f0018f2d4" xlink:to="loc_us-gaap_MaximumRemainingMaturityOfForeignCurrencyDerivatives1_019db75b-9944-7651-b055-826c87e89d72" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityNotionalAmount_019db75b-d5d6-7fd6-a77a-db113f986267" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilityNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_019db75b-9944-79ec-9c63-925f0018f2d4" xlink:to="loc_us-gaap_DerivativeLiabilityNotionalAmount_019db75b-d5d6-7fd6-a77a-db113f986267" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019db75b-d5d6-7aaf-9775-61902720fdbe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_019db75b-9944-79ec-9c63-925f0018f2d4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019db75b-d5d6-7aaf-9775-61902720fdbe" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_AccumulatedComprehensiveIncomeLossTranslationAdjustmentsOnNetInvestmentHedgeNetOfTax_019db75b-d5d6-75ee-98dc-39b699ed2a10" xlink:href="ma-20260331.xsd#ma_AccumulatedComprehensiveIncomeLossTranslationAdjustmentsOnNetInvestmentHedgeNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_019db75b-9944-79ec-9c63-925f0018f2d4" xlink:to="loc_ma_AccumulatedComprehensiveIncomeLossTranslationAdjustmentsOnNetInvestmentHedgeNetOfTax_019db75b-d5d6-75ee-98dc-39b699ed2a10" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/DerivativeandHedgingInstrumentsFairValueofCompanysDerivativeFinancialInstrumentsDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#DerivativeandHedgingInstrumentsFairValueofCompanysDerivativeFinancialInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/DerivativeandHedgingInstrumentsFairValueofCompanysDerivativeFinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019d9cbf-bd7c-7b7f-99b5-da1b9b1a2481" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019d9cbf-bd7c-7351-9be5-384fa07f1e31" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019d9cbf-bd7c-7b7f-99b5-da1b9b1a2481" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019d9cbf-bd7c-7351-9be5-384fa07f1e31" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019d9cbf-bd7c-7b81-821b-ef77cc028f51" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019d9cbf-bd7c-7351-9be5-384fa07f1e31" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019d9cbf-bd7c-7b81-821b-ef77cc028f51" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_019d9cbf-bd7c-7b81-821b-ef77cc028f51_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019d9cbf-bd7c-7b81-821b-ef77cc028f51" xlink:to="loc_us-gaap_HedgingRelationshipDomain_019d9cbf-bd7c-7b81-821b-ef77cc028f51_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_019d9cbf-bd7c-783e-a6fc-5877b30cd246" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_019d9cbf-bd7c-7b81-821b-ef77cc028f51" xlink:to="loc_us-gaap_HedgingRelationshipDomain_019d9cbf-bd7c-783e-a6fc-5877b30cd246" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_019d9cbf-bd7c-716b-b89a-59f10db27699" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019d9cbf-bd7c-783e-a6fc-5877b30cd246" xlink:to="loc_us-gaap_CashFlowHedgingMember_019d9cbf-bd7c-716b-b89a-59f10db27699" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgingMember_019d9cbf-bd7c-788b-9efc-add155ed7adf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019d9cbf-bd7c-783e-a6fc-5877b30cd246" xlink:to="loc_us-gaap_FairValueHedgingMember_019d9cbf-bd7c-788b-9efc-add155ed7adf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_019d9cbf-bd7c-7030-b43a-fcbc44e45e2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_019d9cbf-bd7c-783e-a6fc-5877b30cd246" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_019d9cbf-bd7c-7030-b43a-fcbc44e45e2d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_019d9cbf-bd7c-7f78-9c17-4a4f415ffb00" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019d9cbf-bd7c-7351-9be5-384fa07f1e31" xlink:to="loc_us-gaap_HedgingDesignationAxis_019d9cbf-bd7c-7f78-9c17-4a4f415ffb00" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_019d9cbf-bd7c-7f78-9c17-4a4f415ffb00_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_019d9cbf-bd7c-7f78-9c17-4a4f415ffb00" xlink:to="loc_us-gaap_HedgingDesignationDomain_019d9cbf-bd7c-7f78-9c17-4a4f415ffb00_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_019d9cbf-bd7c-76db-933f-e6c6b1404cea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_019d9cbf-bd7c-7f78-9c17-4a4f415ffb00" xlink:to="loc_us-gaap_HedgingDesignationDomain_019d9cbf-bd7c-76db-933f-e6c6b1404cea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_019d9cbf-bd7c-7d2b-951c-e59685ca4d43" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_019d9cbf-bd7c-76db-933f-e6c6b1404cea" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_019d9cbf-bd7c-7d2b-951c-e59685ca4d43" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_019d9cbf-bd7c-791c-8fab-0cdda49d7b89" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_019d9cbf-bd7c-76db-933f-e6c6b1404cea" xlink:to="loc_us-gaap_NondesignatedMember_019d9cbf-bd7c-791c-8fab-0cdda49d7b89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-7155-9851-8b26fd1ebe8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019d9cbf-bd7c-7351-9be5-384fa07f1e31" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-7155-9851-8b26fd1ebe8a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7155-9851-8b26fd1ebe8a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-7155-9851-8b26fd1ebe8a" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7155-9851-8b26fd1ebe8a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7162-b699-6cf141194b77" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-7155-9851-8b26fd1ebe8a" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7162-b699-6cf141194b77" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019d9cbf-bd7c-733a-8f12-f2733dbab50a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7162-b699-6cf141194b77" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019d9cbf-bd7c-733a-8f12-f2733dbab50a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_019d9cbf-bd7c-79c4-96be-a79e95fd93d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7162-b699-6cf141194b77" xlink:to="loc_us-gaap_InterestRateContractMember_019d9cbf-bd7c-79c4-96be-a79e95fd93d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_019d9cbf-bd7c-76e6-a5b4-e366cd1e40fd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019d9cbf-bd7c-7b7f-99b5-da1b9b1a2481" xlink:to="loc_us-gaap_DerivativeNotionalAmount_019d9cbf-bd7c-76e6-a5b4-e366cd1e40fd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_019d9cbf-bd7c-7a2b-b780-5a5383d325c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019d9cbf-bd7c-7b7f-99b5-da1b9b1a2481" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_019d9cbf-bd7c-7a2b-b780-5a5383d325c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_019d9cbf-bd7c-72a0-b8b8-e2770dac9eac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019d9cbf-bd7c-7b7f-99b5-da1b9b1a2481" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_019d9cbf-bd7c-72a0-b8b8-e2770dac9eac" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/DerivativeandHedgingInstrumentsGainLossRelatedtotheCompanysDerivativeFinancialInstrumentsDesignatedasHedgingInstrumentsDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#DerivativeandHedgingInstrumentsGainLossRelatedtotheCompanysDerivativeFinancialInstrumentsDesignatedasHedgingInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/DerivativeandHedgingInstrumentsGainLossRelatedtotheCompanysDerivativeFinancialInstrumentsDesignatedasHedgingInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019db751-e202-74fb-b85d-df9aec010d26" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019db751-a278-7fb0-9de8-ec08f14027b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019db751-e202-74fb-b85d-df9aec010d26" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019db751-a278-7fb0-9de8-ec08f14027b4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019db751-e202-72ab-89d6-d8e2fad0122a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019db751-a278-7fb0-9de8-ec08f14027b4" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019db751-e202-72ab-89d6-d8e2fad0122a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019db751-e202-72ab-89d6-d8e2fad0122a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019db751-e202-72ab-89d6-d8e2fad0122a" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019db751-e202-72ab-89d6-d8e2fad0122a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019db751-e202-7630-8afa-fb11bc3ef921" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019db751-e202-72ab-89d6-d8e2fad0122a" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019db751-e202-7630-8afa-fb11bc3ef921" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019db751-e202-70bf-8cad-62d57eb42bea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019db751-e202-7630-8afa-fb11bc3ef921" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019db751-e202-70bf-8cad-62d57eb42bea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019db759-4cd3-713b-b5fb-e7b6fc82b01a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019db751-a278-7fb0-9de8-ec08f14027b4" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_019db759-4cd3-713b-b5fb-e7b6fc82b01a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019db751-e202-72be-ac67-836fbfa92c50" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019db751-e202-74fb-b85d-df9aec010d26" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019db751-e202-72be-ac67-836fbfa92c50" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_019db751-e202-729e-b93e-e9b376b3870f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019db751-e202-74fb-b85d-df9aec010d26" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_019db751-e202-729e-b93e-e9b376b3870f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019d9cbf-bd7c-7c70-a1f1-1b32cc85d6cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019db751-e202-74fb-b85d-df9aec010d26" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019d9cbf-bd7c-7c70-a1f1-1b32cc85d6cd" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/DerivativeandHedgingInstrumentsGainLossRelatedtotheCompanysDerivativeFinancialInstrumentsDesignatedasHedgingInstrumentsDetails_1" xlink:type="simple" xlink:href="ma-20260331.xsd#DerivativeandHedgingInstrumentsGainLossRelatedtotheCompanysDerivativeFinancialInstrumentsDesignatedasHedgingInstrumentsDetails_1"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/DerivativeandHedgingInstrumentsGainLossRelatedtotheCompanysDerivativeFinancialInstrumentsDesignatedasHedgingInstrumentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019db751-e202-74fb-b85d-df9aec010d26" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019db751-a278-7fb0-9de8-ec08f14027b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019db751-e202-74fb-b85d-df9aec010d26" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019db751-a278-7fb0-9de8-ec08f14027b4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019db751-e202-72ab-89d6-d8e2fad0122a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_019db751-a278-7fb0-9de8-ec08f14027b4" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019db751-e202-72ab-89d6-d8e2fad0122a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019db751-e202-72ab-89d6-d8e2fad0122a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019db751-e202-72ab-89d6-d8e2fad0122a" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019db751-e202-72ab-89d6-d8e2fad0122a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019db751-e202-7630-8afa-fb11bc3ef921" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019db751-e202-72ab-89d6-d8e2fad0122a" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019db751-e202-7630-8afa-fb11bc3ef921" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019db751-e202-70bf-8cad-62d57eb42bea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019db751-e202-7630-8afa-fb11bc3ef921" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019db751-e202-70bf-8cad-62d57eb42bea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019db751-e202-72be-ac67-836fbfa92c50" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019db751-e202-74fb-b85d-df9aec010d26" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_019db751-e202-72be-ac67-836fbfa92c50" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_019db751-e202-729e-b93e-e9b376b3870f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019db751-e202-74fb-b85d-df9aec010d26" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_019db751-e202-729e-b93e-e9b376b3870f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019d9cbf-bd7c-7c70-a1f1-1b32cc85d6cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_019db751-e202-74fb-b85d-df9aec010d26" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_019d9cbf-bd7c-7c70-a1f1-1b32cc85d6cd" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/DerivativeandHedgingInstrumentsGainLossRecognizedinIncomefortheContractstoPurchaseandSellForeignCurrencySummaryDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#DerivativeandHedgingInstrumentsGainLossRecognizedinIncomefortheContractstoPurchaseandSellForeignCurrencySummaryDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/DerivativeandHedgingInstrumentsGainLossRecognizedinIncomefortheContractstoPurchaseandSellForeignCurrencySummaryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_019d9cbf-bd7c-72e9-89ff-2f7218c215bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019d9cbf-bd7c-72e4-a0d9-ef4e19eea72e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_019d9cbf-bd7c-72e9-89ff-2f7218c215bc" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019d9cbf-bd7c-72e4-a0d9-ef4e19eea72e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-79ca-b382-de98b48d5caa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_019d9cbf-bd7c-72e4-a0d9-ef4e19eea72e" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-79ca-b382-de98b48d5caa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-79ca-b382-de98b48d5caa_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-79ca-b382-de98b48d5caa" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-79ca-b382-de98b48d5caa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7153-9cce-f776147e224c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_019d9cbf-bd7c-79ca-b382-de98b48d5caa" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7153-9cce-f776147e224c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_019d9cbf-bd7c-77e5-ad03-aeae4fe3b9b4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_019d9cbf-bd7c-7153-9cce-f776147e224c" xlink:to="loc_us-gaap_ForeignExchangeContractMember_019d9cbf-bd7c-77e5-ad03-aeae4fe3b9b4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019d9cbf-bd7c-757c-8c55-3e9571d226fc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019d9cbf-bd7c-72e9-89ff-2f7218c215bc" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019d9cbf-bd7c-757c-8c55-3e9571d226fc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossStatementOfIncomeOrComprehensiveIncomeExtensibleEnumeration_019d9cbf-bd7c-7288-b0bc-ce214503bff6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeGainLossStatementOfIncomeOrComprehensiveIncomeExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_019d9cbf-bd7c-72e9-89ff-2f7218c215bc" xlink:to="loc_us-gaap_DerivativeGainLossStatementOfIncomeOrComprehensiveIncomeExtensibleEnumeration_019d9cbf-bd7c-7288-b0bc-ce214503bff6" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.mastercard.us/role/SegmentReportingDetails" xlink:type="simple" xlink:href="ma-20260331.xsd#SegmentReportingDetails"/>
  <link:definitionLink xlink:role="http://www.mastercard.us/role/SegmentReportingDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019d9cbf-bd7c-7b80-8cf4-96b5e868616c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019d9cbf-bd7c-7b80-8cf4-96b5e868616c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019d9cbf-bd7c-719b-8cd0-e4bebc04e8e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019d9cbf-bd7c-7b80-8cf4-96b5e868616c" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019d9cbf-bd7c-719b-8cd0-e4bebc04e8e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019d9cbf-bd7c-719b-8cd0-e4bebc04e8e2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019d9cbf-bd7c-719b-8cd0-e4bebc04e8e2" xlink:to="loc_us-gaap_SegmentDomain_019d9cbf-bd7c-719b-8cd0-e4bebc04e8e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019d9cbf-bd7c-7605-9e0a-81153689de8b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019d9cbf-bd7c-719b-8cd0-e4bebc04e8e2" xlink:to="loc_us-gaap_SegmentDomain_019d9cbf-bd7c-7605-9e0a-81153689de8b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_PaymentSolutionsMember_019d9cbf-bd7c-719f-b39d-ce38a06789d8" xlink:href="ma-20260331.xsd#ma_PaymentSolutionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019d9cbf-bd7c-7605-9e0a-81153689de8b" xlink:to="loc_ma_PaymentSolutionsMember_019d9cbf-bd7c-719f-b39d-ce38a06789d8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019d9cbf-bd7c-7a74-93bf-98534c69ff44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_Revenues_019d9cbf-bd7c-7a74-93bf-98534c69ff44" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_019d9cbf-bd7c-75e2-9066-c394cc53c38b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_LaborAndRelatedExpense_019d9cbf-bd7c-75e2-9066-c394cc53c38b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalFees_019d9cbf-bd7c-76d5-99f0-b9966428621c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfessionalFees"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_ProfessionalFees_019d9cbf-bd7c-76d5-99f0-b9966428621c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InformationTechnologyAndDataProcessing_019d9cbf-bd7c-77f7-a9f5-7ac6eb9a9fbe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InformationTechnologyAndDataProcessing"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_InformationTechnologyAndDataProcessing_019d9cbf-bd7c-77f7-a9f5-7ac6eb9a9fbe" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019d9cbf-bd7c-708b-9667-bc3ca6c17bac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019d9cbf-bd7c-708b-9667-bc3ca6c17bac" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketingAndAdvertisingExpense_019d9cbf-bd7c-7229-9865-b88ae46d896c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketingAndAdvertisingExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_MarketingAndAdvertisingExpense_019d9cbf-bd7c-7229-9865-b88ae46d896c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_019d9cbf-bd7c-7993-99ae-0653a57d4ade" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_DepreciationAndAmortization_019d9cbf-bd7c-7993-99ae-0653a57d4ade" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementExpense_019d9cbf-bd7c-7fad-ab4c-417b26bd54c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationSettlementExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_LitigationSettlementExpense_019d9cbf-bd7c-7fad-ab4c-417b26bd54c2" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNet_019d9cbf-bd7c-7bd9-88a3-89b517fdf42e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_InvestmentIncomeNet_019d9cbf-bd7c-7bd9-88a3-89b517fdf42e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_EquitySecuritiesFVNIAndWithoutReadilyDeterminableFairValueGainLoss_019d9cbf-bd7c-7903-a060-95b1511d4be2" xlink:href="ma-20260331.xsd#ma_EquitySecuritiesFVNIAndWithoutReadilyDeterminableFairValueGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_ma_EquitySecuritiesFVNIAndWithoutReadilyDeterminableFairValueGainLoss_019d9cbf-bd7c-7903-a060-95b1511d4be2" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019d9cbf-bd7c-7943-b7b1-739dd9c8bbf9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019d9cbf-bd7c-7943-b7b1-739dd9c8bbf9" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019d9cbf-bd7c-7f9d-8817-e152e8059cee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019d9cbf-bd7c-7f9d-8817-e152e8059cee" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019d9cbf-bd7c-718b-b03f-23d615d3360c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019d9cbf-bd7c-718b-b03f-23d615d3360c" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_019d9cbf-bd7c-7ac9-bff1-24c5a9b44342" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_019d9cbf-bd7c-7ac9-bff1-24c5a9b44342" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019d9cbf-bd7c-7875-8d1b-c287d6881ccb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d9cbf-bd7c-7a75-8ef1-0d669d3dca70" xlink:to="loc_us-gaap_ProfitLoss_019d9cbf-bd7c-7875-8d1b-c287d6881ccb" xlink:type="arc" order="14"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#IndividualsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AllIndividualsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_RajSeshadriMember_019d9cbf-bb3e-7930-846a-08d730af8709" xlink:href="ma-20260331.xsd#ma_RajSeshadriMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_ma_RajSeshadriMember_019d9cbf-bb3e-7930-846a-08d730af8709" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/TradingArrangementsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#TradingArrangmentsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/TradingArrangementsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllTradingArrangementsMember" xlink:href="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd#ecd_AllTradingArrangementsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_TradingArrangementClassACommonStockUnderlyingEmployeeStockOptionsMember_019d9cbf-bb3e-7a90-b649-b31fe2742b09" xlink:href="ma-20260331.xsd#ma_TradingArrangementClassACommonStockUnderlyingEmployeeStockOptionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllTradingArrangementsMember" xlink:to="loc_ma_TradingArrangementClassACommonStockUnderlyingEmployeeStockOptionsMember_019d9cbf-bb3e-7a90-b649-b31fe2742b09" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ma_TradingArrangementClassACommonStockUnderlyingPerformanceStockUnitsMember_019d9cbf-bb3e-7f3f-889d-e7bb701a3900" xlink:href="ma-20260331.xsd#ma_TradingArrangementClassACommonStockUnderlyingPerformanceStockUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllTradingArrangementsMember" xlink:to="loc_ma_TradingArrangementClassACommonStockUnderlyingPerformanceStockUnitsMember_019d9cbf-bb3e-7f3f-889d-e7bb701a3900" xlink:type="arc" order="2"/>
  </link:definitionLink>
</link:linkbase>
