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Property, Plant and Equipment (Tables)
12 Months Ended
Dec. 31, 2021
Property, Plant and Equipment [Abstract]  
Summary of Property, Plant and Equipment
Property, plant and equipment consisted of the following (in millions):
 
    
As of December 31,
 
    
2021
    
2020
 
Land
   $ 20.1      $ 20.4  
Building and equipment
     2,086.0        1,973.9  
Capitalized software costs
     454.9        425.9  
Instruments
     3,460.4        3,191.0  
Construction in progress
     116.3        121.9  
    
 
 
    
 
 
 
       6,137.7        5,733.1  
Accumulated depreciation
     (4,301.1      (3,869.3
    
 
 
    
 
 
 
Property, plant and equipment, net
   $ 1,836.6      $ 1,863.8