Property, Plant and Equipment

12 Months Ended

Dec. 31, 2022

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

8.Property, Plant and Equipment

Property, plant and equipment consisted of the following (in millions):

	As of December 31,
	2022			2021
Land	$	19.2		$	20.1
Building and equipment		2,093.4			2,086.0
Capitalized software costs		518.2			454.9
Instruments		3,683.5			3,460.4
Construction in progress		144.1			116.3
		6,458.4			6,137.7
Accumulated depreciation		(4,585.9	)		(4,301.1	)
Property, plant and equipment, net	$	1,872.5		$	1,836.6

Depreciation expense was $399.6 million, $408.1 million and $386.3 million for the years ended December 31, 2022, 2021 and 2020, respectively.

We had $17.0 million and $10.3 million of property, plant and equipment included in accounts payable as of December 31, 2022 and 2021, respectively.