<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001136856</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001068851</issuerCik>
      <issuerName>PROSPERITY BANCSHARES INC</issuerName>
      <secFileNumber>001-35388</secFileNumber>
      <issuerAddress>
        <com:street1>4295 SAN FELIPE</com:street1>
        <com:street2>N/A</com:street2>
        <com:city>HOUSTON</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>77027</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>7136939300</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>HOLMES NED S</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>UBS Financial Services, Inc.</name>
        <address>
          <com:street1>11 Madison Avenue</com:street1>
          <com:street2>4th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10010</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>15400</noOfUnitsSold>
      <aggregateMarketValue>1089088.00</aggregateMarketValue>
      <noOfUnitsOutstanding>100854689</noOfUnitsOutstanding>
      <approxSaleDate>06/10/2026</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/31/2002</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>7000</amountOfSecuritiesAcquired>
      <paymentDate>05/31/2002</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/22/2001</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>7000</amountOfSecuritiesAcquired>
      <paymentDate>05/22/2001</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/17/2002</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1400</amountOfSecuritiesAcquired>
      <paymentDate>12/17/2002</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ned S Holmes</name>
        <address>
          <com:street1>4295 SAN FELIPE</com:street1>
          <com:city>HOUSTON</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77027</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/11/2026</saleDate>
      <amountOfSecuritiesSold>6500</amountOfSecuritiesSold>
      <grossProceeds>442042.70</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Ned S Holmes Profit Sharing Plan</name>
        <address>
          <com:street1>4295 SAN FELIPE</com:street1>
          <com:city>HOUSTON</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77027</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/11/2026</saleDate>
      <amountOfSecuritiesSold>6500</amountOfSecuritiesSold>
      <grossProceeds>442036.70</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Sherrill S Holmes Child's Trust FBO Allison Holmes</name>
        <address>
          <com:street1>4295 SAN FELIPE</com:street1>
          <com:city>HOUSTON</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77027</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/11/2026</saleDate>
      <amountOfSecuritiesSold>1300</amountOfSecuritiesSold>
      <grossProceeds>88383.22</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>7,000 shares represented in this filing are being sold under Ned S Holmes. 7,000 shares represented in this filing are being sold under Ned S Holmes Profit Sharing Plan. 1,400 shares represented in this filing are being sold under The Sherrill S Holmes Child's Trust FBO Allison Holmes. Between 3/11/2026 and 6/9/2026 6,500 shares were sold by Ned S. Holmes resulting gross proceeds of $442,042.70; 6,500 shares were sold by Ned S. Holmes Profit Sharing Plan resulting in gross proceeds of $442,036.70 and 1,300 shares were sold by The Sherrill S Holmes Child's Trust FBO Allison Holmes resulting in gross proceeds of $88,383.22. Itemized details are provided in the attached Exhibit.</remarks>
    <noticeSignature>
      <noticeDate>06/10/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>07/30/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ UBS Financial Services Inc, as attorney-in-fact for Ned S Holmes</signature>
    </noticeSignature>
  </formData>

</edgarSubmission>
