X0306 4 2012-12-18 0 0001068851 PROSPERITY BANCSHARES INC PB 0001136856 HOLMES NED S 55 WAUGH DRIVE, SUITE 1111 HOUSTON TX 77027 1 0 0 0 Common Stock 2012-12-18 4 P 0 2000 42.618 A 2000 I By spouse Common Stock 158305 D Common Stock 104400 I By profit sharing plan Common Stock 8820 I As trustee of granchildren's trust Common Stock 48500 I As trustee of SSH trust for adult daughter Common Stock 27500 I As trustee of SSH trust for adult daughter Common Stock 2480 I By trust Common Stock 2480 I By trust Common Stock 70070 I By limited partnership The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $42.59 to $42.62, inclusive. The reporting person undertakes to provide to Prosperity Bancshares, Inc., any security holder of Prosperity Bancshares, Inc., or the staff of the Securities Eschange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote. Includes 923 shares acquired through the Prosperity Bancshares, Inc. dividend reinvestment plan since the last filing by the reporting person. /s/ Ned S. Holmes 2012-12-19