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Stock Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2019
Share-based Payment Arrangement [Abstract]  
Schedule of assumptions used in the Black-Scholes option-pricing model
The assumptions used in the Black-Scholes option-pricing model are determined as follows:

December 31, 2019December 31, 2018
Volatility100.34 %
100.34% - 102.90
Risk-free interest rate
1.63%-2.60%
2.56% - 2.85%
Expected life (in years)
2.85-6.08
2.4 - 6.08
Dividend yield0 %0 %
Schedule of stock option activity
A summary of stock option activity for employee and director grants is as follows:
Number of
Shares Outstanding		Weighted-
Average
Exercise Price
Balance, December 31, 20171,885,383  $11.46  
Stock options granted1,985,539  7.70  
Stock options forfeited and canceled(109,644) 14.29  
Balance, December 31, 20183,761,278  $9.44  
Exercisable at December 31, 2018721,766  $17.14  
Stock options granted1,459,289  14.18  
Stock options exercised(195,351) 9.69  
Stock options forfeited and canceled(1,068,865) 10.36  
Balance at December 31, 20193,956,351  $10.93  
Exercisable at December 31, 20191,062,178  $11.24  
Schedule of warrants granted to non-employees outstanding A summary of warrants granted to non-employees outstanding as of December 31, 2019 and 2018 is as follows:
Number of
Warrants Outstanding		Weighted-
Average
Exercise Price
Warrants issued in connection with debt agreements224,440  $16.04  
Warrants issued for services4,167  13.82  
Balance at December 31, 2019228,607  $16.00  

Number of Warrants OutstandingWeighted-
Average
Exercise Price
Warrants issued in connection with debt agreements9,720  $7.72  
Warrants issued for services24,000  4.68  
Balance at December 31, 201833,720  $5.56  
Schedule of warrant activity
A summary of warrant activity for the years ended December 31, 2019 and 2018 is as follows:
Number of
Warrants Outstanding		Weighted-
Average
Exercise Price
Balance at December 31, 20172,011,528  $4.85  
Warrants granted33,720  5.56  
Warrants exercised(436,252) (4.70) 
Balance at December 31, 20181,608,996  $4.71  
Warrants granted228,607  16.00  
Warrants exercised(232,461) (4.85) 
Warrants expired(54,167) (12.46) 
Balance at December 31, 20191,550,975  $6.08  
Schedule of performance based and market based issuances
Issuances under this structure are as follows:
Grant Date
Performance Measures
Vesting Term
Performance Period
# of Shares
Exercise Price
December 2017
Weighted Average Price of our common stock is $15.00 for at least twenty trading days within a period of thirty consecutive trading days ending on the trading day prior to January 1, 2023.
Fully vest on January 1, 2023
January 1, 2023
642,307  $7.50  
August 2018
Weighted Average Price of our common stock is $15.00 for at least twenty trading days within a period of thirty consecutive trading days ending on the trading day prior to January 1, 2023.
Fully vest on January 1, 2023
January 1, 2023
397,693  $7.50  
April 2018The Options will be divided into five equal tranches and Performance Targets to be established by Board of Directors for each tranche at the beginning of the fiscal year
Amended and vested 115,950 options based on severance agreement
Amended and vested 115,950 options based on severance agreement
115,950  $7.50  
August 2018The Options will be divided into five equal tranches and Performance Targets to be established by Board of Directors for each tranche at the beginning of the fiscal yearAmended and fully forfeited based on severance agreementAmended and fully forfeited based on severance agreement—  $7.50