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Income Taxes (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Deferred tax assets deferred gain on intercompany sale of intangible assets     $ 943
Income tax expense (benefit) $ (544) $ (43)  
Components of U.S. and foreign loss from continuing operations before income taxes      
United States (6,145) (16,149)  
Foreign (46,587) (25,738)  
Loss before income taxes (52,732) $ (41,887)  
SWITZERLAND      
Amortization period     5 years
Income tax expense (benefit) 37    
NETHERLANDS      
Income tax expense (benefit) 32    
In Process Research and Development      
Income tax expense (benefit) (185)    
In Process Research and Development | CANADA      
Income tax expense (benefit) $ (434)