X0306 4 2016-02-27 0 0001135906 EPIRUS Biopharmaceuticals, Inc. EPRS 0001612551 Munshi Amit C/O EPIRUS BIOPHARMACEUTICALS, INC. 699 BOYLSTON STREET, 8TH FLOOR BOSTON MA 02116 1 1 0 0 Chief Executive Officer Common Stock 2016-02-27 4 M 0 1519 A 171501 I See Footnote Common Stock 2016-02-27 4 M 0 9887 A 181388 I See Footnote Common Stock 2016-02-27 4 F 0 4305 2.80 D 177083 I See Footnote Restricted Stock Units 2016-02-27 4 M 0 1519 0.00 D Common Stock 1519 0 I See Footnote Restricted Stock Units 2016-02-27 4 M 0 9887 0.00 D Common Stock 9887 29661 I See Footnote Each Restricted Stock Unit ("RSU") represented a contingent right to receive a share of the Issuer's common stock, vested in full on February 27, 2016, and had no expiration date. All shares are held by the Amit D Munshi Revocable Trust Dated April 12, 2011, for which the Reporting Person serves as trustee. Each RSU represents a contingent right to receive a share of the Issuer's common stock, vests in four (4) substantially equal annual installments beginning on February 27, 2016 provided the Reporting Person remains continuously employed by the Issuer through each vesting date, and has no expiration date. Represents shares of the Issuer's common stock withheld by the Issuer to satisfy tax obligations relating to the acquisition of shares of the Issuer's common stock in connection with the settlement of the vested portions of the RSUs as reflected in this Form 4. Represents the closing price of shares of the Issuer's common stock on the business day prior to the vesting date for such RSUs. /s/ Marina Breed, Attorney-in-Fact 2016-03-01