X0306 4 2015-11-09 0 0001135906 EPIRUS Biopharmaceuticals, Inc. EPRS 0001657494 Vincent Aurentz C/O EPIRUS BIOPHARMACEUTICALS, INC. 699 BOYLSTON STREET, 8TH FLOOR BOSTON MA 02116 0 1 0 0 Chief Business Officer Non-Qualified Stock Option (Right to Buy) 5.21 2015-11-09 4 A 0 219487 0.00 A 2025-11-09 Common Stock 219487 219487 D 25% of the shares subject to this option shall vest on the one year anniversary of the grant date and the remaining shares shall vest in substantially equal monthly installments over the next three (3) years, provided the Reporting Person remains continuously employed by the Issuer through each vesting date. /s/ Marina Breed, Attorney-in-Fact 2015-11-10