<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2018-08-01</periodOfReport>

    <issuer>
        <issuerCik>0001069308</issuerCik>
        <issuerName>Acer Therapeutics Inc.</issuerName>
        <issuerTradingSymbol>ACER</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001640880</rptOwnerCik>
            <rptOwnerName>TVM Life Science Ventures VII L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TVM CAPITAL GROUP</rptOwnerStreet1>
            <rptOwnerStreet2>204, RUE NOTRE-DAME OUEST, BUREAU 350</rptOwnerStreet2>
            <rptOwnerCity>MONTREAL</rptOwnerCity>
            <rptOwnerState>A8</rptOwnerState>
            <rptOwnerZipCode>H2Y 1T3</rptOwnerZipCode>
            <rptOwnerStateDescription>QUEBEC, CANADA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001398598</rptOwnerCik>
            <rptOwnerName>Birner Hubert</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TVM CAPITAL GROUP</rptOwnerStreet1>
            <rptOwnerStreet2>OTTOSTRASSE 4</rptOwnerStreet2>
            <rptOwnerCity>MUNICH</rptOwnerCity>
            <rptOwnerState>2M</rptOwnerState>
            <rptOwnerZipCode>80333</rptOwnerZipCode>
            <rptOwnerStateDescription>GERMANY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001639971</rptOwnerCik>
            <rptOwnerName>Marengere Luc</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TVM CAPITAL GROUP</rptOwnerStreet1>
            <rptOwnerStreet2>OTTOSTRASSE 4</rptOwnerStreet2>
            <rptOwnerCity>MUNICH</rptOwnerCity>
            <rptOwnerState>2M</rptOwnerState>
            <rptOwnerZipCode>80333</rptOwnerZipCode>
            <rptOwnerStateDescription>GERMANY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001398596</rptOwnerCik>
            <rptOwnerName>Fischer Stefan</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TVM CAPITAL GROUP</rptOwnerStreet1>
            <rptOwnerStreet2>OTTOSTRASSE 4</rptOwnerStreet2>
            <rptOwnerCity>MUNICH</rptOwnerCity>
            <rptOwnerState>2M</rptOwnerState>
            <rptOwnerZipCode>80333</rptOwnerZipCode>
            <rptOwnerStateDescription>GERMANY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001133921</rptOwnerCik>
            <rptOwnerName>SCHUHSLER HELMUT</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TVM CAPITAL GROUP</rptOwnerStreet1>
            <rptOwnerStreet2>OTTOSTRASSE 4</rptOwnerStreet2>
            <rptOwnerCity>MUNICH</rptOwnerCity>
            <rptOwnerState>2M</rptOwnerState>
            <rptOwnerZipCode>80333</rptOwnerZipCode>
            <rptOwnerStateDescription>GERMANY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001750983</rptOwnerCik>
            <rptOwnerName>Beeby Reshentha</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TVM CAPITAL GROUP</rptOwnerStreet1>
            <rptOwnerStreet2>OTTOSTRASSE 4</rptOwnerStreet2>
            <rptOwnerCity>MUNICH</rptOwnerCity>
            <rptOwnerState>2M</rptOwnerState>
            <rptOwnerZipCode>80333</rptOwnerZipCode>
            <rptOwnerStateDescription>GERMANY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001718117</rptOwnerCik>
            <rptOwnerName>Leatt Gary</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TVM CAPITAL GROUP</rptOwnerStreet1>
            <rptOwnerStreet2>OTTOSTRASSE 4</rptOwnerStreet2>
            <rptOwnerCity>MUNICH</rptOwnerCity>
            <rptOwnerState>2M</rptOwnerState>
            <rptOwnerZipCode>80333</rptOwnerZipCode>
            <rptOwnerStateDescription>GERMANY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2018-08-01</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>275000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>18.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1697709</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">These shares are directly held by TVM Life Science Ventures VII L.P. (&quot;TVM VII LP&quot;). TVM Life Science Ventures VII (GP) Ltd. (&quot;TVM VII GP Ltd&quot;) is the general partner of TVM VII LP. Hubert Birner (&quot;Birner&quot;), Stefan Fischer (&quot;Fischer&quot;), Helmut Schuhsler (&quot;Schuhsler&quot;), Luc Marengere (&quot;Marengere&quot;), Reshentha Beeby (&quot;Beeby&quot;), and Gary Leatt (&quot;Leatt&quot;) are members of the investment committee of TVM VII GP Ltd, which has voting and investment power with respect to these shares. TVM VII GP Ltd, Birner, Fischer, Schuhsler, Marengere, Beeby and Leatt each disclaim any beneficial ownership of the reported securities, except to the extent of any pecuniary interest therein, if any. Marengere is a director of the Issuer.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Stefan Fischer, Director of TVM Life Science Ventures VII (GP) Ltd., general partner of TVM Life Science Ventures VII L.P.</signatureName>
        <signatureDate>2018-08-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Stefan Fischer, Attorney in Fact for Hubert Birner</signatureName>
        <signatureDate>2018-08-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Luc Marengere</signatureName>
        <signatureDate>2018-08-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Stefan Fischer</signatureName>
        <signatureDate>2018-08-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Stefan Fischer, Attorney in Fact for Helmut Schuhsler</signatureName>
        <signatureDate>2018-08-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Reshentha Beeby</signatureName>
        <signatureDate>2018-08-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Gary Leatt</signatureName>
        <signatureDate>2018-08-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
