X0306 4 2017-01-03 0 0001133869 CAPRICOR THERAPEUTICS, INC. CAPR 0001593089 Smith Rachel C/O CAPRICOR THERAPEUTICS, INC. 8840 WILSHIRE BLVD., 2ND FLOOR BEVERLY HILLS CA 90211 0 1 0 0 Vice President of R&D Stock Option (right to buy) 2.55 2017-01-03 4 A 0 35000 0 A 2027-01-03 Common Stock 35000 35000 D 1/48th of the shares subject to the stock option award shall vest on the first day of each month, commencing February 1, 2017, until the stock option becomes fully vested and exercisable. However, the option is subject to early exercise and, therefore, all or any part of the option can be exercised at any time. If the reporting person elects to take advantage of the early exercise feature and purchase shares prior to the vesting of such shares, the shares will be deemed restricted stock and will be subject to a repurchase option in favor of the Registrant if the reporting person's service to the Registrant terminates prior to vesting. /s/ Linda Marban, as Attorney-in-Fact 2017-01-04