X0305 4 2012-03-30 0001133869 Nile Therapeutics, Inc. NLTX 0001189164 BREWER RICHARD B C/O NILE THERAPEUTICS, INC. 4 WEST 4TH AVENUE, SUITE 400 SAN MATEO CA 94402 1 1 0 0 Executive Chairman Common Stock 2012-03-30 4 P 0 125000 A 125000 D Stock Option (Right to Buy) .32 2010-07-21 2020-07-21 Common Stock 450000 450000 D Stock Option (Right to Buy) .37 2020-07-26 Common Stock 900000 900000 D Warrant (Right to Buy) .50 2012-03-30 4 P 0 93750 0 A Common Stock 93750 93750 D The reported securities were purchased by the Reporting Person at an aggregate price of $0.40 for one share of common stock and three-fourths of a warrant to purchase one share of common stock. This option vests in eight equal quarterly installments beginning 9/30/2011. The warrants are exercisable for a period of five years beginning on the earlier of (i) the date on which a registration statement under the Securities Act of 1933, as amended, covering the shares of common stock issuable upon exercise of the warrants and the subsequent resale of such shares is declared effective by the Securities and Exchange Commission, and (ii) one year and one day after issuance. /s/ Daron Evans as Attorney-in-Fact for Richard B. Brewer pursuant to Power of Attorney previously filed. 2012-04-02