X0303 4 2008-08-01 0 0001069530 PAIN THERAPEUTICS INC ptie 0001133806 BARBIER REMI 1 1 1 0 President and CEO Common Stock 2008-08-01 4 S 0 25000 8.33 D 6800200 D Common Stock 2008-08-04 4 S 0 25000 8.35 D 6775200 D Common Stock 2008-08-01 4 P 0 125000 0 A 6900200 D This proposed sale is made pursuant to a plan intended to comply with Rule 10b5-1(c), previously adopted on February 7, 2007 when I was not aware of material non-public information. Pursuant to a 10b5-1(c) plan, 25,000 shares were sold in twenty-three (23) lots at prices ranging from $8.24 and $8.53 per share. Pursuant to a 10b5-1(c) plan, 25,000 shares were sold in nineteen (19) lots at prices ranging from $8.26 and $8.45 per share. These shares are issued under the Issuer's 2008 Equity Incentive Plan subject to the attainment of a performance goal. These shares are subject to repurchase by the Issuer. The Issuer's right to repurchase these shares lapses upon the achievement of the performance goal and other criteria established in connection with issuing these shares. /s/ Remi Barbier 2008-08-04