<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144/A</submissionType>
    <previousAccessionNumber>0001628280-25-056844</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001557082</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001133416</issuerCik>
      <issuerName>GALECTIN THERAPEUTICS INCORPORATED</issuerName>
      <secFileNumber>001-31791</secFileNumber>
      <issuerAddress>
        <com:street1>4960 PEACHTREE INDUSTRIAL BLVD</com:street1>
        <com:street2>SUITE 240</com:street2>
        <com:city>NORCROSS</com:city>
        <com:stateOrCountry>GA</com:stateOrCountry>
        <com:zipCode>30071</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>678-620-3186</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>HAROLD SHLEVIN</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>DIRECTOR</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>NEIL MEHTA</name>
        <address>
          <com:street1>401 E. LAS OLAS BLVD. 9TH FLOOR</com:street1>
          <com:city>FORT LAUDERDALE</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33301</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>19793</noOfUnitsSold>
      <aggregateMarketValue>122993</aggregateMarketValue>
      <noOfUnitsOutstanding>64472792</noOfUnitsOutstanding>
      <approxSaleDate>12/12/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>12/12/2025</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK OPTION</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>19793</amountOfSecuritiesAcquired>
      <paymentDate>12/12/2025</paymentDate>
      <natureOfPayment>CASH</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>HAROLD SHLEVIN</name>
        <address>
          <com:street1>8196 MOUNT THOR LN</com:street1>
          <com:city>BOYNTON BEACH</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33473</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <saleDate>12/09/2025</saleDate>
      <amountOfSecuritiesSold>16790</amountOfSecuritiesSold>
      <grossProceeds>104198.72</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>HAROLD SHLEVIN</name>
        <address>
          <com:street1>8196 MOUNT THOR LN</com:street1>
          <com:city>BOYNTON BEACH</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33473</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
      <saleDate>12/08/2025</saleDate>
      <amountOfSecuritiesSold>159000</amountOfSecuritiesSold>
      <grossProceeds>943448.33</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>12/12/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/29/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>HAROLD SHLEVIN</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
