Stockholders' Deficit - Additional Information (Detail) (USD $)	0 Months Ended																		1 Months Ended							3 Months Ended	12 Months Ended					162 Months Ended		12 Months Ended		2 Months Ended			0 Months Ended		0 Months Ended	12 Months Ended		12 Months Ended				12 Months Ended	162 Months Ended				12 Months Ended		0 Months Ended							12 Months Ended		0 Months Ended								0 Months Ended		12 Months Ended			0 Months Ended			0 Months Ended	12 Months Ended		16 Months Ended		12 Months Ended	0 Months Ended												1 Months Ended	12 Months Ended		16 Months Ended			12 Months Ended								0 Months Ended									1 Months Ended	0 Months Ended									1 Months Ended	0 Months Ended									1 Months Ended					12 Months Ended				12 Months Ended						0 Months Ended	12 Months Ended				0 Months Ended					12 Months Ended				0 Months Ended		12 Months Ended
	Aug. 16, 2013	Mar. 28, 2012	Mar. 22, 2012	May 10, 2010	Apr. 30, 2010	Mar. 08, 2010	Jan. 29, 2010	Dec. 08, 2009	Nov. 04, 2009	Sep. 30, 2009	Aug. 12, 2009	Jun. 30, 2009	Feb. 12, 2009	Jul. 02, 2008	May 21, 2008	Feb. 25, 2008	Feb. 04, 2008	Jan. 14, 2003	Mar. 23, 2012	Dec. 30, 2010	May 13, 2009	May 31, 2003	Jan. 31, 2003	Sep. 30, 2002	Aug. 31, 2001	Jun. 30, 2008	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2002	Dec. 31, 2001	Dec. 31, 2013	Dec. 26, 2008	Dec. 31, 2013 At Market Agreement	Oct. 25, 2013 At Market Agreement	Feb. 28, 2014 At Market Agreement Subsequent Event	Jan. 14, 2003 Advisor	Dec. 31, 2002 Advisor	Jan. 14, 2003 Finder and Finder's Agents	Dec. 31, 2002 Finder and Finder's Agents	Jan. 14, 2003 Employee	Dec. 31, 2003 Employee	Dec. 31, 2002 Employee	Dec. 31, 2003 Scientific Advisory Services	Dec. 31, 2002 Scientific Advisory Services	Dec. 31, 2011 Series B Directors Person	Dec. 31, 2011 Series B Nominees Person	Dec. 31, 2013 Additional Paid-in Capital	Dec. 31, 2013 Additional Paid-in Capital	Dec. 31, 2011 Minimum	Dec. 31, 2011 Maximum	Dec. 31, 2011 Maximum Series B Nominees Person	Dec. 31, 2002 Public Offering	Dec. 13, 2001 Public Offering	Aug. 12, 2004 Institutional Investors	Apr. 07, 2004 Institutional Investors	Oct. 02, 2003 Institutional Investors	Aug. 12, 2004 Placement Agent	Apr. 07, 2004 Placement Agent	Oct. 02, 2003 Placement Agent	Mar. 22, 2012 Underwriting Agreement	Dec. 31, 2001 Warrant one	Dec. 31, 2001 Warrant two	Feb. 25, 2008 Warrant three	Feb. 25, 2008 Warrant three Placement Agent	Feb. 25, 2008 Warrant 4	Feb. 25, 2008 Warrant 5	Feb. 25, 2008 Warrant 6	Mar. 28, 2012 Warrant 7	Mar. 22, 2012 Warrant 7	Apr. 30, 2009 Warrant 7	Feb. 04, 2008 Warrant	Dec. 31, 2011 Warrant	Dec. 31, 2011 Series A One Warrant	Dec. 31, 2013 Series A Two Warrant	Dec. 31, 2011 Series A Two Warrant	Jan. 31, 2014 Series A Two Warrant Subsequent Event	Dec. 31, 2011 Series A and B Warrants	Dec. 31, 2012 Series A Redeemable Convertible Preferred Stock	Feb. 12, 2009 Series B-1 12% redeemable convertible preferred stock	Dec. 31, 2013 Series B-1 12% redeemable convertible preferred stock	Dec. 31, 2009 Series B-1 12% redeemable convertible preferred stock	May 31, 2010 Series B-1 12% redeemable convertible preferred stock	Dec. 31, 2012 Series B-1 12% redeemable convertible preferred stock	Dec. 31, 2013 Series B-1 12% redeemable convertible preferred stock Additional Paid-in Capital	Feb. 12, 2009 Series B-1 12% redeemable convertible preferred stock Class A One Warrants	Feb. 12, 2009 Series B-1 12% redeemable convertible preferred stock Class A-2 Warrants	Feb. 12, 2009 Series B-1 12% redeemable convertible preferred stock Class B Warrants	May 10, 2010 Series B-2 12% redeemable convertible preferred stock	Apr. 30, 2010 Series B-2 12% redeemable convertible preferred stock	Mar. 08, 2010 Series B-2 12% redeemable convertible preferred stock	Jan. 29, 2010 Series B-2 12% redeemable convertible preferred stock	Dec. 08, 2009 Series B-2 12% redeemable convertible preferred stock	Nov. 04, 2009 Series B-2 12% redeemable convertible preferred stock	Sep. 30, 2009 Series B-2 12% redeemable convertible preferred stock	Aug. 12, 2009 Series B-2 12% redeemable convertible preferred stock	Jun. 30, 2009 Series B-2 12% redeemable convertible preferred stock	May 13, 2009 Series B-2 12% redeemable convertible preferred stock	Dec. 31, 2010 Series B-2 12% redeemable convertible preferred stock	Dec. 31, 2009 Series B-2 12% redeemable convertible preferred stock	May 31, 2010 Series B-2 12% redeemable convertible preferred stock	Dec. 31, 2013 Series B-2 12% redeemable convertible preferred stock	Dec. 31, 2012 Series B-2 12% redeemable convertible preferred stock	Dec. 31, 2010 Series B-2 12% redeemable convertible preferred stock Additional Paid-in Capital	Dec. 31, 2009 Series B-2 12% redeemable convertible preferred stock Additional Paid-in Capital	Dec. 31, 2010 Series B-2 12% redeemable convertible preferred stock Beneficial Conversion Feature	Dec. 31, 2009 Series B-2 12% redeemable convertible preferred stock Beneficial Conversion Feature	Dec. 31, 2010 Series B-2 12% redeemable convertible preferred stock Minimum	Dec. 31, 2009 Series B-2 12% redeemable convertible preferred stock Minimum	Dec. 31, 2010 Series B-2 12% redeemable convertible preferred stock Maximum	Dec. 31, 2009 Series B-2 12% redeemable convertible preferred stock Maximum	May 10, 2010 Series B-2 12% redeemable convertible preferred stock Class A One Warrants	Apr. 30, 2010 Series B-2 12% redeemable convertible preferred stock Class A One Warrants	Mar. 08, 2010 Series B-2 12% redeemable convertible preferred stock Class A One Warrants	Jan. 29, 2010 Series B-2 12% redeemable convertible preferred stock Class A One Warrants	Dec. 08, 2009 Series B-2 12% redeemable convertible preferred stock Class A One Warrants	Nov. 04, 2009 Series B-2 12% redeemable convertible preferred stock Class A One Warrants	Sep. 30, 2009 Series B-2 12% redeemable convertible preferred stock Class A One Warrants	Aug. 12, 2009 Series B-2 12% redeemable convertible preferred stock Class A One Warrants	Jun. 30, 2009 Series B-2 12% redeemable convertible preferred stock Class A One Warrants	May 13, 2009 Series B-2 12% redeemable convertible preferred stock Class A One Warrants	May 10, 2010 Series B-2 12% redeemable convertible preferred stock Class A-2 Warrants	Apr. 30, 2010 Series B-2 12% redeemable convertible preferred stock Class A-2 Warrants	Mar. 08, 2010 Series B-2 12% redeemable convertible preferred stock Class A-2 Warrants	Jan. 29, 2010 Series B-2 12% redeemable convertible preferred stock Class A-2 Warrants	Dec. 08, 2009 Series B-2 12% redeemable convertible preferred stock Class A-2 Warrants	Nov. 04, 2009 Series B-2 12% redeemable convertible preferred stock Class A-2 Warrants	Sep. 30, 2009 Series B-2 12% redeemable convertible preferred stock Class A-2 Warrants	Aug. 12, 2009 Series B-2 12% redeemable convertible preferred stock Class A-2 Warrants	Jun. 30, 2009 Series B-2 12% redeemable convertible preferred stock Class A-2 Warrants	May 13, 2009 Series B-2 12% redeemable convertible preferred stock Class A-2 Warrants	May 10, 2010 Series B-2 12% redeemable convertible preferred stock Class B Warrants	Apr. 30, 2010 Series B-2 12% redeemable convertible preferred stock Class B Warrants	Mar. 08, 2010 Series B-2 12% redeemable convertible preferred stock Class B Warrants	Jan. 29, 2010 Series B-2 12% redeemable convertible preferred stock Class B Warrants	Dec. 08, 2009 Series B-2 12% redeemable convertible preferred stock Class B Warrants	Nov. 04, 2009 Series B-2 12% redeemable convertible preferred stock Class B Warrants	Sep. 30, 2009 Series B-2 12% redeemable convertible preferred stock Class B Warrants	Aug. 12, 2009 Series B-2 12% redeemable convertible preferred stock Class B Warrants	Jun. 30, 2009 Series B-2 12% redeemable convertible preferred stock Class B Warrants	May 13, 2009 Series B-2 12% redeemable convertible preferred stock Class B Warrants	Dec. 31, 2013 Series C super dividend convertible preferred stock	Jul. 31, 2011 Series C super dividend convertible preferred stock	Jan. 31, 2011 Series C super dividend convertible preferred stock	Dec. 30, 2010 Series C super dividend convertible preferred stock	Dec. 31, 2013 Series C super dividend convertible preferred stock	Dec. 31, 2011 Series C super dividend convertible preferred stock	Dec. 31, 2012 Series C super dividend convertible preferred stock	Dec. 29, 2010 Series C super dividend convertible preferred stock	Dec. 31, 2011 Series C super dividend convertible preferred stock Minimum	Dec. 31, 2011 Series C super dividend convertible preferred stock Maximum	Dec. 31, 2011 Series C super dividend convertible preferred stock First Payment	Dec. 31, 2011 Series C super dividend convertible preferred stock Second Payment	Dec. 31, 2011 Series C super dividend convertible preferred stock Series A Preferred Stock	Dec. 31, 2011 Series C super dividend convertible preferred stock Series B One Preferred Stock	Feb. 04, 2008 Series A 12% Convertible Preferred Stock	Dec. 31, 2013 Series A 12% Convertible Preferred Stock	Dec. 31, 2012 Series A 12% Convertible Preferred Stock	Dec. 31, 2011 Series A 12% Convertible Preferred Stock	Dec. 31, 2008 Series A 12% Convertible Preferred Stock	Feb. 04, 2008 Series A 12% Convertible Preferred Stock Minimum	Feb. 04, 2008 Series A 12% Convertible Preferred Stock Scenario 1	Feb. 04, 2008 Series A 12% Convertible Preferred Stock Scenario 2	Feb. 04, 2008 Series A 12% Convertible Preferred Stock First Payment	Feb. 04, 2008 Series A 12% Convertible Preferred Stock Second Payment	Dec. 31, 2007 Series A 12% Convertible Preferred Stock Period 1	Dec. 31, 2008 Series A 12% Convertible Preferred Stock Period 2	Dec. 31, 2013 Common Stock	Dec. 31, 2012 Common Stock	Jan. 26, 2011 Series B redeemable convertible preferred stock	Feb. 12, 2009 Series B redeemable convertible preferred stock	Dec. 31, 2013 Series B redeemable convertible preferred stock	Dec. 31, 2011 Series B redeemable convertible preferred stock	Jan. 26, 2011 Series B redeemable convertible preferred stock Minimum
Class of Stock [Line Items]
Common stock, shares authorized																											50,000,000	50,000,000				50,000,000
Undesignated stock, shares authorized																											20,000,000	20,000,000				20,000,000
Undesignated stock, designated																											8,001,000	8,001,000				8,001,000																																															5,000,000					900,000																			2,100,000																																													1,000
Undesignated stock, undesignated																												11,999,000
Shares of common stock issued	500,000	2,666,722														1,250,000		181,334				399,917								537,227	114,884			99,942		2,663,647																	31,000		333,334	206,019	219,096																							900,000		900,000	900,000						285,000	155,000	167,500	162,500	162,500	155,000	162,500	150,000	250,000	450,000	770,000	1,330,000	2,100,000																																											13	212
Proceeds from sale of common stock	$ 3,000,000																	$ 1,070,000				$ 4,671,000								$ 2,861,000	$ 2,221,000
Stock issuance costs	0															369,000		18,000				128,000								212,000	17,000								3,000														49,000		485,000	466,000	559,000															3,000																																																																									47,000											52,000
Warrants issued	0	46,378												50,000			1,400			500		18,269								18,334																									333,334	103,010	109,549	16,667	10,301	10,955		56,534	58,350	1,250,000	34,375	500,000																	1,800,000			300,000	300,000	1,200,000													4,200,000											95,000	51,667	55,834	54,167	54,167	51,666	54,166	50,000	83,333	150,000	95,000	51,667	55,834	54,167	54,167	51,666	54,166	50,000	83,333	150,000	380,000	206,667	223,334	216,667	216,667	206,666	216,666	200,000	333,333	600,000
Exercise price of warrant														6.00			9.00			7.20		32.40			39.00					21.00																									4.20	31.80	31.74	4.20	31.80	41.16	5.63	39.00	30.00	3.50	4.20	3.78					3.00							3.00
Fair value of warrants																2,281,000	984,000					261,000			503,000					236,000	886,000																								4,786,000	1,931,000	2,531,000	239,000	154,000	191,000																					1,296,000																		4,148,000	5,333,000
Fair market value of common stock per share																$ 2.40	$ 3.54						$ 6.00		$ 13.68		$ 8.08			$ 21.00	$ 13.68	$ 8.08																		$ 9.00											$ 9.00																																																																																						$ 3.00
Convertible debt outstanding principal and accrued interest																									1,126,000
Conversion price per share																									$ 12.00
Debt conversion, shares issued																									99,705
Debt conversion, warrants issued																									93,801
Common stock warrant term																														10 years
Price of common stock per share																$ 3.00																		$ 9.02																				$ 21.00	$ 18.00	$ 21.60	$ 21.00
Proceeds from issuance of common stock																											3,833,000	10,403,000				42,926,000		833,000		28,178,000																	602,000		5,515,000	3,983,000	4,041,000
Private placement, number of shares issuable																						416,667		1,666,667																																	238,096
Private placement, price per share																						$ 12.00		$ 6.00
Common stock, subscription receivable																														150,000
Common stock issuable for compensation																														29,042							417	28,917	1,625	125	1,167		350		4,226
Additional share Issued																							2,042
Offering Cost payable																							18,000
Common stock issued for compensation, shares																																										350		4,226
Common stock issued for compensation, value																																									27,000	6,000
Expiration date of warrant		May 02, 2016																																																											Mar. 28, 2017			Aug. 25, 2013
Net proceeds from issuance of stock and warrants		10,403,000		536,000	297,000	322,000	308,000	310,000	296,000	305,000	287,000	473,000	1,548,000			3,381,000					801,000																																																													1,548,000			1,105,000														1,463,000	2,472,000				1,028,000	1,732,000	388,000	628,000																																																	1,691,000
Costs for warrants issued to placement agent																56,000
Fair value of common stock issued																1,044,000											3,833,000					77,400,000																3,832,000
Fair value assumptions, term of warrants																																																																			5 years	4 months	5 years	4 years 1 month 6 days											5 years																		5 years	5 years
Fair value assumptions, warrants exercise price																																																																			$ 4.20	$ 3.78	$ 4.20	$ 4.20
Fair value assumptions, risk free interest rate																	2.51%																																																		2.94%	2.13%	1.05%	0.78%											1.79%																											2.27%	1.98%	2.43%	2.70%
Fair value assumptions, volatility rate																	95.00%																																																		95.00%	95.00%	119.00%	117.00%											118.00%																											126.00%	124.00%	129.00%	127.00%
Change in fair value of warrant liabilities															100,000											356,000			524,000			(9,022,000)
Warrant liability credited to additional paid in capital														20,000	502,000											2,160,000	(8,763,000)
Warrants expired unexercised																																	500,000
Exercise price of warrants expired unexercised																																	$ 3.78
Proceeds from issuance of warrants														20,000
Term of warrants														3 years
Units issued		1,333,361																																																											1,159,445
Number of common stock in each units issued																																																													2
Number of warrant in each units issued																																																													1
Number of common stock to be purchased with each warrant																																																													1
Period of option to purchase additional units to cover over-allotments																																																													45 days
Additional units authorize for issuance to cover over-allotments																																																													173,916
Warrants to purchase shares of common stock issued		1,333,361
Gross proceeds from issuance of stock and warrants		12,000,000
Warrants issuance value		4,445,000	143,000																									4,445,000				9,482,000
Warrant exercise value		5.63																									4,505,000					18,812,000																4,504,000	18,808,000
Reverse stock split ratio																			1.6667
Issuance of shares related to reverse split of common stock																			3,324
Aggregate offering price																																			30,000,000
Commission to sales agent as a percentage of gross proceeds																																			3.00%
Gross proceeds from sale of common stock																																		944,000
Initial legal and accounting costs																																		82,000
Commissions																																		29,000
Preferred stock, dividend rate																																																																																																																																																			6.00%									12.00%			12.00%													12.00%
Stock price per share																																																																																																																																																$ 10,000	$ 10,000											$ 6.00						$ 9.00	$ 12.00
Share of Series A Preferred in each unit issued																																																																																																																																																												1
Number of warrant to purchase one share of common stock in each unit issued																																																																																																																																																												1
Dividend per share																																																																																																																																																																	$ 6.00
Dividend, percentage of value weighted average share price																																																																																																																																																												100.00%																100.00%
Number of consecutive trading days prior to dividend payment date																																																																																																																																																			10 days									20 days																20 days
Dividend payable date																																																																																																																																																								--03-31	--09-30											--03-30	--09-30
Convertible stock conversion ratio																																																																																																																																																												0.1667																	0.667
Minimum closing price of the common stock to require conversion																																																																																																																																																						$ 18.00											$ 18.00
Number of consecutive trading days for conversion of preferred stock																																																																																																																																																			15 days									15 days																	15 days
Subscription advances received																																																																																																																																																																1,742,500						1,667,500	75,000
Conversion of Series A to common stock																																																																																																																																																													110,000	180,000										18,387	30,000
Preferred stock issuable																																																																																																																																																																											3,000,000
Preferred stock value																																																																																																																																																																											6,000,000
Common shares issuable upon conversion of preferred stock																																																																																600,000									190,000	103,334	111,667	108,334	108,333	103,333	108,333	100,000	166,666	300,000																																																	1,667																								2,000,000
Warrants issuable													6,000,000
Dividends accrue rate																																																																																																																																																																												15.00%
Convertible stock conversion price																																																																																																																																																			$ 6.00																										$ 3.00
Notice period for conversion of preferred stock at the option of the company																																																																																																																																																																													10 days
Number of consecutive trading days for redemption of preferred stock																																																																																																																																																																														30 days
Preferred stock redemption date																																																																																																																																																																										Feb. 12, 2019
Promissory note, interest rate																													15.00%
Liquidation preference per share after series A preferred stock																																																																																																																																																			$ 10,000																									$ 2
Number of board of directors																																														2	2					3
Maximum increase in number of shares issuable without approval of the holders of the majority of shares of series B outstanding																																																			250,000
Termination notice period																																																																									30 days
Number of consecutive trading days																																																																										15 days
Market value of common stock																																																																										$ 7.50		$ 10.50
Cash proceeds from warrant exercises																											1,500,000																																															3,000,000	1,500,000		1,500,000
Number of warrants exercised																																																																											500,000		500,000
Fair value assumptions, dividend rate																																																																																	0.00%																		0.00%	0.00%
Preferred stock shares designated for issuance																											5,000,000	5,000,000				5,000,000																																																																																																																					1,000
Preferred stock, par value																																																																																																																																																					$ 0.01
Preferred stock, stated value																																																																																																																																																					$ 10,000
Proceeds from issuance of preferred stock																																																																																																																																																130,000	2,120,000
Proceeds from issuance of preferred stock, net																																																																																																																																																	2,073,000
Convertible preferred shares																																																																																																																																														24	5			196
Common stocks issued upon conversion of Preferred Stock																											81,591	51,830																																																																																																																		40,193	8,334			326,667
Dividend as percentage of net sales																																																																																																																																																										2.50%	1.25%
Convertible preferred stock dividend																																																																																																																																																							100,000
Post conversion dividend rights issued																																																																																																																																														24	5
Redemption period																																																																																																																																																							30 days
Post conversion redemption right, return on investment multiplier amount																																																																																																																																																			10,000
Preferred stock redemption price																																																																																																																																																			$ 3.00
Number of trading days ending immediately prior to the date of redemption																																																																																																																																																			10 days
Convertible preferred stock, redemption value																																																																																	$ 1,800,000																					$ 4,200,000																																								$ 5,547,000				$ 5,547,000