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Stock-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2023
Stock-Based Compensation [Abstract]  
Components of Stock-Based Compensation Expense
Following is the stock-based compensation expense related to common stock options, restricted common stock, common stock warrants and deferred stock units:

   
Year Ended
December 31,
 
   
2023
   
2022
 
Research and development
 
$
829
   
$
810
 
General and administrative
   
1,432
     
2,057
 
Total stock-based compensation expense
 
$
2,261
   
$
2,867
 
Weighted Average Assumptions Used to Determine Fair Value of Options Granted
The fair value of the options granted is determined using the Black-Scholes option-pricing model. The following weighted average assumptions were used:

   
2023
   
2022
 
Risk-free interest rate
   
3.84
%
   
1.85
%
Expected life of the options
 
5.6 years
   
5.7 years
 
Expected volatility of the underlying stock
   
85.6
%
   
93.7
%
Expected dividend rate
   
0
%
   
0
%
Stock Option Activity
The following table summarizes the stock option activity in the stock-based compensation plans:

   
Number of
Shares
   
Weighted
Average
Exercise
Price
     
Weighted
Average
Remaining
Contractual
Life
(in years)
        
Aggregate
Intrinsic Value
(in thousands)
 
Outstanding, December 31, 2021
   
4,895,561
   
$
3.14
                         
Granted
   
1,070,000
     
1.75
                         
Forfeited/Cancelled
   
(220,000
)
   
2.68
                         
Exercised
   
   
                         
Outstanding, December 31, 2022
   
5,745,561
   
$
2.90
                         
Granted
   
1,025,000
     
1.18
                         
Forfeited/Cancelled
   
(436,720
)
   
2.23
                         
Exercised
   
   
                         
Outstanding, December 31, 2023
   
6,333,841
   
$
2.66
     
6.77 
     $
632
 
Exercisable, December 31, 2023
   
4,541,761
    $ 2.79      
6.54 
     $
447 
 
Outstanding and Exercisable Options under Stock Based Compensation Plans
The following table summarizes additional information regarding outstanding and exercisable options under our stock-based compensation plans at December 31, 2023:

     
Options Outstanding
   
Options Exercisable
 
Exercise
Price (Range)
   
Number of
Shares
   
Weighted
Average
Remaining
Contractual
Life
   
Weighted
Average
Exercise
Price
   
Number of
Shares
   
Weighted
Average
Exercise
Price
 
           
(in years)
                   
$0.87 – 1.00
     
120,500
     
2.96
   
$
0.89
     
120,500
   
$
0.89
 
$1.01 – 3.00
     
5,046,604
     
7.45
     
2.01
     
3,302,857
     
2.09
 
$3.01 – 5.00
     
809,237
     
4.98
     
4.28
     
760,904
     
4.71
 
$5.01 – 8.00
     
220,000
     
4.11
     
5.92
     
220,000
     
5.92
 
$8.01 – 13.38
     
137,500
     
0.06
     
13.38
     
137,500
     
13.38
 
        
6,333,841
     
6.77
   
$
2.66
     
4,541,761
   
$
2.79