Income Taxes, Primary Factors Affecting Income Tax Rates (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Primary Factors Affecting Income Tax Rates [Abstract]
Tax benefit at U.S. statutory rates	(21.00%)	(21.00%)
State tax benefit	4.20%	(4.70%)
Permanent differences	0.50%	0.50%
Other	(1.40%)	(0.10%)
Changes in valuation allowance	17.70%	25.30%
Income tax rate, total	0.00%	0.00%
Federal and Sate [Abstract]
Deferred tax asset valuation allowance percentage in each of the last two years		100.00%
Operating loss carryforwards expiration year		2037
Federal and state research and development credits expiration year		2042
Federal [Member]
Federal and Sate [Abstract]
Research and development credits		$ 2,276,000
Federal [Member] | Expiring as a Result of 2017 Tax Act [Member]
Federal and Sate [Abstract]
Net operating loss carryforwards	$ 80,810,000
Federal [Member] | Expiring Through 2037 [Member]
Federal and Sate [Abstract]
Net operating loss carryforwards	131,317,000
State [Member]
Federal and Sate [Abstract]
Research and development credits		$ 1,282,000
State [Member] | Expiring as a Result of 2017 Tax Act [Member]
Federal and Sate [Abstract]
Net operating loss carryforwards	87,141,000
State [Member] | Expiring Through 2037 [Member]
Federal and Sate [Abstract]
Net operating loss carryforwards	$ 102,003,000