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Cash and Cash Equivalents, and Marketable Securities (Invitae) (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Mar. 31, 2017
Jun. 30, 2018
Jun. 30, 2017
Disposal        
Amount reclassified out of accumulated other comprehensive income       $ 1,127,000
Invitae | Sale | Common Stock        
Disposal        
Proceeds from sales of marketable securities   $ 10,200,000    
Cost per share (in dollars per share)   $ 6.28    
Realized gains on available-for-sale marketable securities   $ 2,800,000    
Number of shares sold 0   0  
Amount reclassified out of accumulated other comprehensive income   1,100,000    
Amount reclassified out of accumulated other comprehensive income, tax portion   $ 821,000