Stock-Based Compensation Employee Stock-Based Compensation Expense (Details) - USD ($)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Employee Stock Based Compensation Expense
Stock-based compensation expense (in dollars)	$ 16,005,000	$ 16,538,000	$ 17,457,000
Unvested Stock Options
Employee Stock Based Compensation Expense
Unrecognized compensation expense (in dollars)	$ 6,700,000
Weighted-average period of recognition of unrecognized stock-based compensation expense	2 years 4 months 24 days
RSUs
Employee Stock Based Compensation Expense
Unrecognized compensation expense (in dollars)	$ 12,300,000
Weighted-average period of recognition of unrecognized stock-based compensation expense	1 year 10 months 24 days
RSUs | Performance-Based Vesting
Employee Stock Based Compensation Expense
Unrecognized compensation expense (in dollars)	$ 12,000
Weighted-average period of recognition of unrecognized stock-based compensation expense	1 month 6 days
Cost of product revenues
Employee Stock Based Compensation Expense
Stock-based compensation expense (in dollars)	$ 525,000	497,000	483,000
Research and development expense.
Employee Stock Based Compensation Expense
Stock-based compensation expense (in dollars)	4,228,000	4,143,000	4,486,000
Selling and marketing
Employee Stock Based Compensation Expense
Stock-based compensation expense (in dollars)	4,526,000	4,822,000	4,756,000
General and administrative
Employee Stock Based Compensation Expense
Stock-based compensation expense (in dollars)	$ 6,726,000	$ 7,076,000	$ 7,732,000