Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenues:
Product revenues	$ 287,458	$ 275,706	$ 259,192
Contract revenues			2,403
Total revenues	287,458	275,706	261,595
Operating expenses:
Cost of product revenues	53,782	48,742	42,100
Research and development	59,798	53,076	64,177
Selling and marketing	143,557	137,846	112,758
General and administrative	64,348	59,669	54,392
Total operating expenses	321,485	299,333	273,427
Loss from operations	(34,027)	(23,627)	(11,832)
Impairment of investments			(643)
Interest income	221	192	222
Other income (expense), net	(498)	(764)	(158)
Loss before income taxes	(34,304)	(24,199)	(12,411)
Income tax (benefit) expense	(996)	393	346
Net loss	$ (33,308)	$ (24,592)	$ (12,757)
Basic and diluted net loss per share (in dollars per share)	$ (1.03)	$ (0.78)	$ (0.42)
Shares used in computing basic and diluted net loss per share (in shares)	32,382	31,453	30,512