X0306 4 2018-12-11 0 0001131324 GENOMIC HEALTH INC GHDX 0001337798 Cole G Bradley 301 PENOBSCOT DRIVE REDWOOD CITY CA 94063 0 1 0 0 CFO Common Stock 2018-12-06 5 G 0 E 1633 0.00 D 44047 I Held by the Cole Family Trust Common Stock 2018-12-11 4 M 0 10000 22.98 A 54047 I Held by the Cole Family Trust Common Stock 2018-12-11 4 M 0 5000 17.18 A 59047 I Held by the Cole Family Trust Common Stock 2018-12-11 4 S 0 2529 70.5843 D 56518 I Held by the Cole Family Trust Common Stock 2018-12-11 4 S 0 4571 71.5372 D 51947 I Held by the Cole Family Trust Common Stock 2018-12-11 4 S 0 700 72.7289 D 51247 I Held by the Cole Family Trust Common Stock 2018-12-11 4 S 0 900 73.5567 D 50347 I Held by the Cole Family Trust Common Stock 2018-12-11 4 S 0 1300 74.6092 D 49047 I Held by the Cole Family Trust Common Stock 2018-12-11 4 S 0 1400 70.6059 D 47647 I Held by the Cole Family Trust Common Stock 2018-12-11 4 S 0 2200 71.5309 D 45447 I Held by the Cole Family Trust Common Stock 2018-12-11 4 S 0 600 73.0951 D 44847 I Held by the Cole Family Trust Common Stock 2018-12-11 4 S 0 800 74.4225 D 44047 I Held by the Cole Family Trust Employee Stock Option (right to buy) 17.18 2018-12-11 4 M 0 5000 0.00 D 2020-02-18 Common Stock 5000 36471 D Employee Stock Option (right to buy) 22.98 2018-12-11 4 M 0 10000 0.00 D 2021-01-27 Common Stock 10000 46424 D Includes an aggregate of 16,534 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. These sales of common stock were effected pursuant to Rule 10b5-1 sales plan adopted by the reporting person on August 23, 2018. Reporting person undertakes to provide upon request by the Securities and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within the range indicated. Represents weighted average sale price. Actual sale prices ranged from $70.08 to $71.07. Represents weighted average sale price. Actual sale prices ranged from $71.11 to $72.05. Represents weighted average sale price. Actual sale prices ranged from $72.11 to $72.97. Represents weighted average sale price. Actual sale prices ranged from $73.14 to $74.00. Represents weighted average sale price. Actual sale prices ranged from $74.29 to $75.22. These sales of common stock were effected pursuant to Rule 10b5-1 sales plan adopted by the reporting person on June 4, 2018. Represents weighted average sale price. Actual sale prices ranged from $70.07 to $71.05. Represents weighted average sale price. Actual sale prices ranged from $71.11 to $72.05. Represents weighted average sale price. Actual sale prices ranged from $72.65 to $73.45. Represents weighted average sale price. Actual sale prices ranged from $73.96 to $74.91. The option became exercisable as to 25% of the shares on February 18, 2011, and became exercisable as to 1/48th of the shares each full month thereafter. The option became exercisable as to 25% of the shares on January 27, 2012, and became exercisable as to 1/48th of the shares each full month thereafter. /s/ Jason W. Radford, Attorney-in-fact 2018-12-13