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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 HIKaM6aHZJ4JZ50cSesFfA==

<SEC-DOCUMENT>0001209191-07-035324.txt : 20070605
<SEC-HEADER>0001209191-07-035324.hdr.sgml : 20070605
<ACCEPTANCE-DATETIME>20070605170222
ACCESSION NUMBER:		0001209191-07-035324
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20070601
FILED AS OF DATE:		20070605
DATE AS OF CHANGE:		20070605

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GENOMIC HEALTH INC
		CENTRAL INDEX KEY:			0001131324
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		IRS NUMBER:				770552594
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		301 PENOBSCOT DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
		BUSINESS PHONE:		650-556-9300

	MAIL ADDRESS:	
		STREET 1:		301 PENOBSCOT DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Baker Joffre
		CENTRAL INDEX KEY:			0001337335

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51541
		FILM NUMBER:		07901699

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		650-569-2261

	MAIL ADDRESS:	
		STREET 1:		301 PENOBSCOT DRIVE
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>bpa30896_bpa1jbb.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2007-06-01</periodOfReport>

    <issuer>
        <issuerCik>0001131324</issuerCik>
        <issuerName>GENOMIC HEALTH INC</issuerName>
        <issuerTradingSymbol>GHDX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001337335</rptOwnerCik>
            <rptOwnerName>Baker Joffre</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>301 PENOBSCOT DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>REDWOOD CITY</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94063</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Scientific Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <transactionDate>
                <value>2007-06-01</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>4629</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>17.5578</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>288990</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">This sale of common stock is pursuant to a Rule 10b5-1 sales plan dated December 5, 2006. The reporting person also continues to indirectly own 116,343 shares of common stock held by the Joffre and Diana J. Baker 1998 Trust.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Joffre B. Baker</signatureName>
        <signatureDate>2007-06-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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