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Stock-Based Compensation - Summary of Weighted Average Assumptions and Fair Value of Options under ESPP (Detail) - Employee Stock Purchase Plan - $ / shares
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Dividend yield 0.00% 0.00%
Expected volatility 93.20% 91.60%
Risk-free interest rate 1.335% 0.49%
Expected term (months) 6 months 6 months
Weighted-average grant-date fair value per share $ 1.16 $ 3.14