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Securities Registrations and Sales Agreements - underwriting agreement with HCW (Details) - USD ($)
$ / shares in Units, $ in Millions
12 Months Ended
May 01, 2018
Apr. 27, 2018
Apr. 16, 2018
Feb. 12, 2018
Feb. 08, 2018
Nov. 14, 2017
Apr. 26, 2017
Dec. 31, 2017
Dec. 31, 2018
Sep. 24, 2018
Jun. 07, 2018
Jun. 06, 2018
Mar. 21, 2018
Mar. 20, 2018
Subsidiary, Sale of Stock [Line Items]                            
Net proceeds from stock offering $ 25.6     $ 8.7                    
Common Stock authorized (in shares)               25,000,000 250,000,000   250,000,000 100,000,000 100,000,000 25,000,000
Percentage of exercise price of warrants     105.00%                      
Common Stock                            
Subsidiary, Sale of Stock [Line Items]                            
Issuance of stock (in shares)               267,418            
Pre-funded warrants                            
Subsidiary, Sale of Stock [Line Items]                            
Warrant exercise price (in dollars per share)   $ 0.15     $ 0.15                  
Preferred stock warrants | Series A Convertible Preferred Stock                            
Subsidiary, Sale of Stock [Line Items]                            
Warrant exercise price (in dollars per share)   $ 6.375                        
Preferred stock warrants | Common Stock                            
Subsidiary, Sale of Stock [Line Items]                            
Warrant exercise price (in dollars per share) $ 6.69375       $ 15.15                  
HCW                            
Subsidiary, Sale of Stock [Line Items]                            
Underwriters commission (in percentage)   8.00%     7.00%                  
Management fee (in percentage)   1.00%     1.00%                  
HCW | Common Stock                            
Subsidiary, Sale of Stock [Line Items]                            
Number of common stock shares for conversion preferred stock received as compensation         33,158                  
HCW | Preferred stock warrants | Common Stock                            
Subsidiary, Sale of Stock [Line Items]                            
Warrants exercise price received as compensation (in dollars per share)         $ 18.9375         $ 7.96875        
The Offering                            
Subsidiary, Sale of Stock [Line Items]                            
Issuance of stock (in shares)           61,333 165,079              
The Offering | Common Stock                            
Subsidiary, Sale of Stock [Line Items]                            
Issuance of stock (in shares)   3,105,882     380,500                  
Share price (in dollars per share)   $ 6.375     $ 15.15                  
The Offering | Pre-funded warrants                            
Subsidiary, Sale of Stock [Line Items]                            
Warrant purchase price (in dollars per share)         $ 15.00                  
The Offering | Pre-funded warrants | Common Stock                            
Subsidiary, Sale of Stock [Line Items]                            
Number of securities to each class of warrant (in shares)   815,686     196,167                  
Underwriter's option | HCW                            
Subsidiary, Sale of Stock [Line Items]                            
Period available to underwriters to purchase additional shares under the offering         30 days                  
Underwriter's option | HCW | Common Stock                            
Subsidiary, Sale of Stock [Line Items]                            
Issuance of stock (in shares)   588,235     86,500                  
Share price (in dollars per share)   $ 6.225     $ 15.00                  
Lock-up period for purchased shares by counterparty (in days)         135 days                  
Underwriter's option | HCW | Preferred stock warrants | Common Stock                            
Subsidiary, Sale of Stock [Line Items]                            
Number of securities to each class of warrant (in shares)   588,235     86,500                  
Warrant purchase price (in dollars per share)   $ 0.15     $ 0.15