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License and Collaboration Agreements - SymBio Agreement (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Apr. 11, 2018
Mar. 02, 2018
Jan. 31, 2018
Jul. 31, 2011
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2018
Dec. 31, 2017
License and collaboration agreements                
Revenue             $ 1,228,000 $ 787,000
Value of stock issued               $ 6,360,000
Common Stock                
License and collaboration agreements                
Issuance of stock (in shares)               267,418
Value of stock issued               $ 3,000
License agreement | SymBio                
License and collaboration agreements                
Percentage of discount on future purchases     35.00%          
License agreement | SymBio | Maximum                
License and collaboration agreements                
Cumulative amount of discount on purchases     $ 300,000          
License agreement | HanX                
License and collaboration agreements                
Upfront payment received $ 450,000              
License agreement | Pint                
License and collaboration agreements                
Revenue         $ 319,000      
License agreement | Rigosertib | SymBio                
License and collaboration agreements                
Upfront payment received       $ 7,500,000        
Aggregate milestone payments       22,000,000        
Aggregate potential milestone payments based on annual net sales       $ 30,000,000        
Percentage of royalty payments based on net sales of rigosertib (as a percent)       20.00%        
License agreement | Rigosertib | Pint                
License and collaboration agreements                
Aggregate potential milestone payments based on annual net sales   $ 41,500,000            
Prior written notice period for termination (in days)   45 days            
License and collaboration | HanX license payment | HanX                
License and collaboration agreements                
Revenue           $ 450,000    
Securities Purchase Agreement | Common Stock | Pint                
License and collaboration agreements                
Issuance of stock (in shares)   54,463            
Value of stock issued   $ 1,250,000            
Amount of premium   $ 319,000,000            
United States and Japan | License agreement | Rigosertib | SymBio                
License and collaboration agreements                
Aggregate milestone payments due upon receipt of marketing approval for an additional indication       $ 4,000,000        
United States | License agreement | Rigosertib | SymBio | MDS IV indication                
License and collaboration agreements                
Regulatory milestones payments due upon receipt of marketing approval for indication       5,000,000        
United States | License agreement | Rigosertib | SymBio | Rigosertib oral in lower risk MDS patients                
License and collaboration agreements                
Regulatory milestones payments due upon receipt of marketing approval for indication       5,000,000        
Japan | License agreement | Rigosertib | SymBio | MDS IV indication                
License and collaboration agreements                
Regulatory milestones payments due upon receipt of marketing approval for indication       3,000,000        
Japan | License agreement | Rigosertib | SymBio | Rigosertib oral in lower risk MDS patients                
License and collaboration agreements                
Regulatory milestones payments due upon receipt of marketing approval for indication       $ 5,000,000