X0202 4 2007-12-17 0 0001130591 XENOPORT INC XNPT 0001326330 Barrett Ronald W C/O XENOPORT, INC. 3410 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 1 1 0 0 Chief Executive Officer Common stock 2007-12-17 4 S 0 200 54.50 D 92886 I By Trust Common stock 2007-12-17 4 S 0 100 54.58 D 92786 I By Trust Common stock 2007-12-17 4 S 0 100 54.35 D 92686 I By Trust Common stock 2007-12-17 4 S 0 100 54.34 D 92586 I By Trust Common stock 2007-12-17 4 S 0 300 54.54 D 92286 I By Trust Common stock 2007-12-17 4 S 0 100 54.97 D 92186 I By Trust Common stock 2007-12-17 4 S 0 100 54.77 D 92086 I By Trust Common stock 2007-12-17 4 S 0 68 54.57 D 92018 I By Trust Common stock 2007-12-17 4 S 0 200 54.55 D 91818 I By Trust Common stock 2007-12-17 4 S 0 100 54.75 D 91718 I By Trust Common stock 2007-12-17 4 S 0 100 53.95 D 91618 I By Trust Common stock 2007-12-17 4 S 0 100 54.24 D 91518 I By Trust Common stock 2007-12-17 4 S 0 100 54.25 D 91418 I By Trust Common stock 2007-12-17 4 S 0 100 54.31 D 91318 I By Trust Common stock 2007-12-17 4 S 0 400 54.50 D 90918 I By Trust Common stock 2007-12-17 4 S 0 100 54.53 D 90818 I By Trust Common stock 2007-12-17 4 S 0 300 54.51 D 90518 I By Trust Common stock 2007-12-17 4 S 0 200 54.63 D 90318 I By Trust Common stock 2007-12-17 4 S 0 100 54.72 D 90218 I By Trust Common stock 2007-12-17 4 S 0 200 54.20 D 90018 I By Trust Common stock 2007-12-17 4 S 0 200 53.73 D 89818 I By Trust Common stock 2007-12-17 4 S 0 100 54.48 D 89718 I By Trust Common stock 2007-12-17 4 S 0 100 54.89 D 89618 I By Trust Common stock 2007-12-17 4 S 0 200 54.59 D 89418 I By Trust Common stock 2007-12-17 4 S 0 132 54.58 D 89286 I By Trust Common stock 2007-12-17 4 S 0 100 54.51 D 89186 I By Trust Common stock 2007-12-17 4 S 0 100 54.62 D 89086 I By Trust Common stock 2007-12-17 4 S 0 97 54.60 D 88989 I By Trust Common stock 2007-12-17 4 S 0 100 54.63 D 88889 I By Trust Common stock 2007-12-17 4 S 0 3 54.54 D 88886 I By Trust These shares were sold by the Ronald W & Sharon S Barrett 1992 Family Trust DTD Feb 6, 1992, to which the reporting person had contributed 276,756 shares of XenoPort, Inc common stock in a transaction that resulted in a change in form of ownership from direct to indirect. The trust's sales were effected pursuant to instructions given to the trustee by the reporting person pursuant to a 10b5-1 trading plan. Form 2 of 3 dated 12/19/2007 /s/ Martyn J. Webster Attorney-in-fact 2007-12-19