X0202 4 2007-12-17 0 0001130591 XENOPORT INC XNPT 0001326330 Barrett Ronald W C/O XENOPORT, INC. 3410 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 1 1 0 0 Chief Executive Officer Common stock 2007-11-20 5 G 0 E 900 0.00 D 176786 I By Trust Common stock 2007-11-20 5 G 0 E 80000 0.00 D 96786 I By Trust Common stock 2007-11-20 5 G 0 E 80000 0.00 A 80000 I By GRAT Common stock 2007-12-17 4 S 0 100 54.34 D 96686 I By Trust Common stock 2007-12-17 4 S 0 100 54.54 D 96586 I By Trust Common stock 2007-12-17 4 S 0 100 54.28 D 96486 I By Trust Common stock 2007-12-17 4 S 0 100 54.48 D 96386 I By Trust Common stock 2007-12-17 4 S 0 100 54.89 D 96286 I By Trust Common stock 2007-12-17 4 S 0 200 54.59 D 96086 I By Trust Common stock 2007-12-17 4 S 0 100 54.18 D 95986 I By Trust Common stock 2007-12-17 4 S 0 100 54.34 D 95886 I By Trust Common stock 2007-12-17 4 S 0 200 54.75 D 95686 I By Trust Common stock 2007-12-17 4 S 0 100 54.97 D 95586 I By Trust Common stock 2007-12-17 4 S 0 100 54.74 D 95486 I By Trust Common stock 2007-12-17 4 S 0 100 54.57 D 95386 I By Trust Common stock 2007-12-17 4 S 0 100 54.54 D 95286 I By Trust Common stock 2007-12-17 4 S 0 200 54.55 D 95086 I By Trust Common stock 2007-12-17 4 S 0 100 53.94 D 94986 I By Trust Common stock 2007-12-17 4 S 0 100 54.24 D 94886 I By Trust Common stock 2007-12-17 4 S 0 100 54.25 D 94786 I By Trust Common stock 2007-12-17 4 S 0 200 54.53 D 94586 I By Trust Common stock 2007-12-17 4 S 0 303 54.50 D 94283 I By Trust Common stock 2007-12-17 4 S 0 297 54.51 D 93986 I By Trust Common stock 2007-12-17 4 S 0 100 54.62 D 93886 I By Trust Common stock 2007-12-17 4 S 0 100 54.72 D 93786 I By Trust Common stock 2007-12-17 4 S 0 200 54.63 D 93586 I By Trust Common stock 2007-12-17 4 S 0 200 53.73 D 93386 I By Trust Common stock 2007-12-17 4 S 0 100 54.20 D 93286 I By Trust Common stock 2007-12-17 4 S 0 100 54.51 D 93186 I By Trust Common stock 2007-12-17 4 S 0 100 54.62 D 93086 I By Trust Of the shares gifted by the reporting person on November 20, 2007, 40,000 shares were gifted to each grantor retained annuity trust of the reporting person and the reporting person's spouse. These shares were sold by the Ronald W & Sharon S Barrett 1992 Family Trust DTD Feb 6, 1992, to which the reporting person had contributed 276,756 shares of XenoPort, Inc common stock in a transaction that resulted in a change in form of ownership from direct to indirect. The trust's sales were effected pursuant to instructions given to the trustee by the reporting person pursuant to a 10b5-1 trading plan. Form 1 of 3 dated 12/19/2007 /s/ Martyn J. Webster Attorney-in-fact 2007-12-19