X0202 4 2006-12-08 0 0001128495 ANADYS PHARMACEUTICALS INC ANDS 0001283307 WORLAND STEPHEN T C/O ANADYS PHARMACEUTICALS, INC. 3115 MERRYFIELD ROW SAN DIEGO CA 92121 0 1 0 0 President, Pharmaceuticals Stock Option (Right to Buy) 4.88 2006-12-08 4 A 0 100000 0.00 A 2007-06-14 2016-12-07 Common Stock 100000 100000 D 25% of the shares subject to the option shall vest and become exercisable on June 14, 2007 with the remaining shares subject to the option vesting in equal monthly installments evenly over the next three year period such that all shares subject to the option will be fully vested and exercisable as of June 14, 2010. /s/ Elizabeth E. Reed as Attorney-in-Fact for Stephen T. Worland 2006-12-12