X0306 4 2021-07-01 0001544227 Tempest Therapeutics, Inc. TPST 0001127430 Pellizzari Christine A 7000 SHORELINE COURT SUITE 275 SOUTH SAN FRANCISCO CA 94080 true Stock Option (Right to Buy) 11.07 2021-07-01 4 A 0 6635 A 2031-06-30 Common Stock 6635 6635 D One-fourth of the shares underlying this option vest on July 1, 2022, and the remaining shares vest in a series of 36 equal monthly installments thereafter, subject to the reporting person's continued service. /s/ Pierre Lorenzo, attorney-in-fact for Christine A. Pellizzari 2021-07-06