X0306 4 2020-05-15 0 0001104506 INSMED Inc INSM 0001127430 Pellizzari Christine A 700 US HIGHWAY 202/206 BRIDGEWATER NJ 08807 0 1 0 0 Chief Legal Officer Common Stock 2020-05-15 4 F 0 1575 25.46 D 94348 D Common Stock 2020-11-03 4 M 0 12683 11.14 A 107031 D Common Stock 2020-11-03 4 S 0 12683 32.34 D 94348 D Common Stock 2020-11-03 4 M 0 10649 11.14 A 104997 D Common Stock 2020-11-03 4 S 0 10649 32.36 D 94348 D Common Stock 2020-11-03 4 M 0 14351 11.14 A 108699 D Common Stock 2020-11-03 4 S 0 14351 32.50 D 94348 D Common Stock 2020-11-03 4 M 0 1000 11.14 A 95348 D Common Stock 2020-11-03 4 S 0 1000 32.61 D 94348 D Common Stock 2020-11-03 4 M 0 11317 11.14 A 105665 D Common Stock 2020-11-03 4 S 0 11317 31.87 D 94348 D Common Stock 2020-11-03 4 M 0 25000 11.14 A 119348 D Common Stock 2020-11-03 4 S 0 25000 32.32 D 94348 D Common Stock 2020-11-03 4 M 0 400 11.14 A 94748 D Common Stock 2020-11-03 4 S 0 400 33.10 D 94348 D Common Stock 2020-11-03 4 M 0 38396 11.14 A 132744 D Common Stock 2020-11-03 4 S 0 38396 32.95 D 94348 D Common Stock 2020-11-04 4 M 0 12311 12.58 A 106659 D Common Stock 2020-11-04 4 S 0 12311 34.10 D 94348 D Common Stock 2020-11-04 4 M 0 2024 12.58 A 96372 D Common Stock 2020-11-04 4 S 0 2024 34.55 D 94348 D Common Stock 2020-11-04 4 M 0 15665 12.58 A 110013 D Common Stock 2020-11-04 4 S 0 15665 34.38 D 94348 D Common Stock 2020-11-05 4 M 0 35904 11.14 A 130252 D Common Stock 2020-11-05 4 M 0 3750 20.49 A 134002 D Stock Option (right to buy) 11.14 2020-11-03 4 M 0 12683 0 D 2023-07-30 Common Stock 12683 101413 D Stock Option (right to buy) 11.14 2020-11-03 4 M 0 10649 0 D 2023-07-30 Common Stock 10649 90764 D Stock Option (right to buy) 11.14 2020-11-03 4 M 0 14351 0 D 2023-07-30 Common Stock 14351 76413 D Stock Option (right to buy) 11.14 2020-11-03 4 M 0 1000 0 D 2023-07-30 Common Stock 1000 75413 D Stock Option (right to buy) 11.14 2020-11-03 4 M 0 11317 0 D 2023-07-30 Common Stock 11317 64096 D Stock Option (right to buy) 11.14 2020-11-03 4 M 0 25000 0 D 2023-07-30 Common Stock 25000 39096 D Stock Option (right to buy) 11.14 2020-11-03 4 M 0 400 0 D 2023-07-30 Common Stock 400 38696 D Stock Option (right to buy) 11.14 2020-11-03 4 M 0 38696 0 D 2023-07-30 Common Stock 38696 0 D Stock Option (right to buy) 12.58 2020-11-04 4 M 0 12311 0 D 2024-06-02 Common Stock 12311 17689 D Stock Option (right to buy) 12.58 2020-11-04 4 M 0 2024 0 D 2024-06-02 Common Stock 2024 15665 D Stock Option (right to buy) 12.58 2020-11-04 4 M 0 15665 0 D 2024-06-02 Common Stock 15665 0 D Stock Option (right to buy) 11.14 2020-11-05 4 M 0 35904 0 D 2023-07-30 Common Stock 35904 0 D Stock Option (right to buy) 20.49 2020-11-05 4 M 0 3750 0 D 2024-01-10 Common Stock 3750 0 D Represents the withholding of shares of common stock to satisfy tax withholding obligations in connection with the vesting of restricted stock units. This transaction was not reported previously due to a clerical error. This is the weighted average sales price representing 12,683 shares sold at prices ranging from $32.02 to $32.58 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 10,649 shares sold at prices ranging from $32.23 to $32.46 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 14,351 shares sold at prices ranging from $32.47 to $32.53 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 1,000 shares sold at prices ranging from $32.60 to $32.64 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 11,317 shares sold at prices ranging from $31.75 to $32.00 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 25,000 shares sold at prices ranging from $32.25 to $32.45 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 38,696 shares sold at prices ranging from $32.81 to $33.09 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 12,311 shares sold at prices ranging from $34.00 to $34.28 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 2,024 shares sold at prices ranging from $34.50 to $34.62 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 15,665 shares sold at prices ranging from $34.28 to $34.49 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. The options became exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. /s/ Christine Pellizzari 2020-11-05