-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 EobTdBEzVX+r0oOdOv6iJg==

<SEC-DOCUMENT>0001179110-05-023096.txt : 20051215
<SEC-HEADER>0001179110-05-023096.hdr.sgml : 20051215
<ACCEPTANCE-DATETIME>20051215171854
ACCESSION NUMBER:		0001179110-05-023096
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20051213
FILED AS OF DATE:		20051215
DATE AS OF CHANGE:		20051215

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Advanced Life Sciences Holdings, Inc.
		CENTRAL INDEX KEY:			0001322734
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				300296543

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(630) 739-6744

	MAIL ADDRESS:	
		STREET 1:		1440 DAVEY ROAD
		CITY:			WOODRIDGE
		STATE:			IL
		ZIP:			60517

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			XU ZE QI
		CENTRAL INDEX KEY:			0001126560

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51436
		FILM NUMBER:		051267472

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		6302571500

	MAIL ADDRESS:	
		STREET 1:		C/O MEDICHEM LIFE SCIENCES INC
		STREET 2:		12305 SOUTH NEW AVENUE
		CITY:			LEMONT
		STATE:			IL
		ZIP:			60439
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 4 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-12-13</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001322734</issuerCik>
        <issuerName>Advanced Life Sciences Holdings, Inc.</issuerName>
        <issuerTradingSymbol>ADLS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001126560</rptOwnerCik>
            <rptOwnerName>XU ZE QI</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1440 DAVEY ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>WOODRIDGE</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60517</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>EVP and CSO</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.38</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-12-13</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>33600</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-12-13</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>33600</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>33600</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The options become exercisable in 1/36th monthly installments beginning December 13, 2005.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Patrick W. Flavin by power of attorney</signatureName>
        <signatureDate>2005-12-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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