X0306 4 2016-02-10 0 0000914475 NEUROCRINE BIOSCIENCES INC NBIX 0001126489 MOLLICA JOSEPH A PO BOX 1182 PRINCETON NJ 08542 1 0 0 0 Common Stock 2016-02-10 5 M 0 E 20000 3.07 A 39175 D Common Stock 2016-02-10 5 F 0 E 1821 33.70 D 37354 D Stock Option 3.07 2016-02-10 5 M 0 E 20000 0.00 D 2009-06-29 2016-05-29 Common Stock 20000 0 D The share issuance reported on Table I reflects shares issued upon the exercise of options granted on May 29, 2009, which, if unexercised, would have expired on May 29, 2016. The option exercises are reported on Table II. These option exercises were pursuant to a new issuance arrangement effected under the issuer's equity incentive plan. The number of shares issued pursuant to the net issuance arrangement was calculated as follows: the option exercise price ($3.07) was subtracted from the February 10, 2016 market close price ($33.70) and this net amount of ($30.63) was then multiplied by the number of options (20,000), with the resulting amount then divided by the market close price to result in a net issuance of 18,179 shares to optionee. The 1,821 shares underlying the remaining portion of the options are not available for reissuance, and no shares are sold into the market as part of the exercise in connection with net issuance program. /s/ Darin Lippoldt, Attorney-In-Fact 2016-02-12