SCHEDULE 13G/A 0001193125-24-262283 0001863769 XXXXXXXX LIVE 2 Common Stock, par value $0.01 per share 12/31/2025 0001125345 MACROGENICS, INC. 556099109 9704 Medical Center Drive Rockville MD 20850 Rule 13d-1(c) Frazier Life Sciences Public Fund, L.P. b DE 0.00 0.00 0.00 0.00 0.00 0.0 PN FHMLSP, L.P. b DE 0.00 0.00 0.00 0.00 0.00 0.0 PN FHMLSP, L.L.C. b DE 0.00 0.00 0.00 0.00 0.00 0.0 OO Frazier Life Sciences X, L.P. b DE 0.00 0.00 0.00 0.00 0.00 0.0 PN FHMLS X, L.P. b DE 0.00 0.00 0.00 0.00 0.00 0.0 PN FHMLS X, L.L.C. b DE 0.00 0.00 0.00 0.00 0.00 0.0 OO Frazier Life Sciences XI, L.P. b DE 0.00 0.00 0.00 0.00 0.00 0.0 PN FHMLS XI, L.P. b DE 0.00 0.00 0.00 0.00 0.00 0.0 PN FHMLS XI, L.L.C. b DE 0.00 0.00 0.00 0.00 0.00 0.0 OO James N. Topper b X1 0.00 0.00 0.00 0.00 0.00 0.0 IN Patrick J. Heron b X1 0.00 0.00 0.00 0.00 0.00 0.0 IN MACROGENICS, INC. 9704 Medical Center Drive, Rockville, MD, 20850. The entities and persons filing this statement (collectively, the "Reporting Persons") are: Frazier Life Sciences Public Fund, L.P. ("FLSPF") FHMLSP, L.P. FHMLSP, L.L.C. Frazier Life Sciences X, L.P. ("FLS X") FHMLS X, L.P. FHMLS X, L.L.C. Frazier Life Sciences XI, L.P. ("FLS XI") FHMLS XI, L.P. FHMLS XI, L.L.C. James N. Topper ("Topper") Patrick J. Heron ("Heron" and together with Topper, the "Members") The address of the principal place of business for each of the Reporting Persons is: c/o Frazier Life Sciences Management, L.P. 1001 Page Mill Rd, Building 4, Suite B Palo Alto, CA 94304 The information contained in row 4 of each Reporting Person's cover page to this Statement is incorporated by reference. Y The information contained in row 9 of each Reporting Person's cover page to this Statement (including the footnotes thereto) is incorporated by reference. Except as specifically stated herein, the filing of this Statement shall not be construed as an admission that any Reporting Person or any of the foregoing is, for the purposes of Section 13(d) and/or Section 13(g) of the Act or otherwise, the beneficial owner of any securities covered by this Statement or a member of a "group" with any other person. The information contained in row 11 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. The information contained in row 5 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. The information contained in row 6 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. The information contained in row 7 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. The information contained in row 8 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement Frazier Life Sciences Public Fund, L.P. /s/ Jennifer Martin 02/13/2026 FHMLSP, L.P. /s/ Jennifer Martin 02/13/2026 FHMLSP, L.L.C. /s/ Jennifer Martin 02/13/2026 Frazier Life Sciences X, L.P. /s/ Jennifer Martin 02/13/2026 FHMLS X, L.P. /s/ Jennifer Martin 02/13/2026 FHMLS X, L.L.C. /s/ Jennifer Martin 02/13/2026 Frazier Life Sciences XI, L.P. /s/ Jennifer Martin 02/13/2026 FHMLS XI, L.P. /s/ Jennifer Martin 02/13/2026 FHMLS XI, L.L.C. /s/ Jennifer Martin 02/13/2026 James N. Topper /s/ Jennifer Martin 02/13/2026 Patrick J. Heron /s/ Jennifer Martin 02/13/2026