CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024
Cash flows from operating activities
Net loss	$ (77,287)	$ (107,854)
Adjustments to reconcile net income loss to net cash used in operating activities:
Depreciation and amortization expense	3,678	3,652
Amortization of premiums and discounts on marketable securities	(493)	(2,254)
Stock-based compensation	8,076	12,204
Non-cash interest expense recognized	587	0
Non-cash lease expense	799	1,228
Other non-cash items	0	21
Changes in operating assets and liabilities:
Accounts receivable	(8,223)	4,176
Inventory	(9,275)	106
Prepaid expenses and other current assets	4,862	673
Other non current assets	159	200
Accounts payable	(388)	(1,243)
Accrued expenses and other current liabilities	(7,651)	450
Lease liabilities	(214)	86
Deferred revenue	(8,205)	(1,573)
Other non current liabilities	(300)	0
Net cash used in operating activities	(93,875)	(90,128)
Cash flows from investing activities
Purchases of marketable securities	(53,428)	(58,505)
Proceeds from sale and maturities of marketable securities	26,936	133,150
Purchases of property, equipment and software	(1,244)	(2,494)
Proceeds from sales of equipment	0	80
Net cash (used in) provided by investing activities	(27,736)	72,231
Cash flows from financing activities
Proceeds from stock option exercises and ESPP purchases	66	3,270
Taxes paid related to net share settlement of equity awards	(282)	(2,397)
Net proceeds from sale of future royalties	69,673	0
Net cash provided by financing activities	69,457	873
Net change in cash and cash equivalents	(52,154)	(17,024)
Cash and cash equivalents at beginning of period	182,840	100,956
Cash and cash equivalents at end of period	130,686	83,932
Supplemental cash flow disclosures
Cash paid for income taxes	105	0
Non-cash operating and investing activities
Property and equipment included in accounts payable or accruals	$ 33	$ 36