March 19, 2019

Robert Stefanovich
Chief Financial Officer
Cryoport, Inc.
17305 Daimler St.
Irvine, CA 92614

       Re: Cryoport, Inc.
           Registration Statement on Form S-3
           Filed March 13, 2019
           File No. 333-230237

Dear Mr. Stefanovich:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Aamira Chaudhry at 202-551-3389 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of
Transportation and Leisure
cc:    Anthony Ippolito, Esq.