Stock-Based Compensation - Range of Exercise Prices and Intrinsic Value Related to Options Outstanding (Details)	12 Months Ended
	Dec. 31, 2021 $ / shares shares
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range
Options Outstanding, Number Outstanding (in shares) | shares	5,490,936
Options Outstanding, Weighted Average Remaining Contractual Life	5 years 7 months 6 days
Options Outstanding, Weighted Average Exercise Price Per Share (in dollars per share)	$ 40.95
Options Exercisable, Number Exercisable (in shares) | shares	3,519,747
Options Exercisable, Weighted Average Remaining Contractual Life	4 years
Options Exercisable, Weighted Average Exercise Price Per Share (In dollars per share)	$ 54.31
$8.81 - $29.50
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range
Range of Exercise Prices, low end of range (in dollars per share)	8.81
Range of Exercise Prices, high end of range (in dollars per share)	$ 29.50
Options Outstanding, Number Outstanding (in shares) | shares	2,413,093
Options Outstanding, Weighted Average Remaining Contractual Life	8 years 4 months 24 days
Options Outstanding, Weighted Average Exercise Price Per Share (in dollars per share)	$ 17.64
Options Exercisable, Number Exercisable (in shares) | shares	456,853
Options Exercisable, Weighted Average Remaining Contractual Life	8 years
Options Exercisable, Weighted Average Exercise Price Per Share (In dollars per share)	$ 21.34
$46.07 - $62.50
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range
Range of Exercise Prices, low end of range (in dollars per share)	46.07
Range of Exercise Prices, high end of range (in dollars per share)	$ 62.50
Options Outstanding, Number Outstanding (in shares) | shares	2,671,436
Options Outstanding, Weighted Average Remaining Contractual Life	3 years 6 months
Options Outstanding, Weighted Average Exercise Price Per Share (in dollars per share)	$ 56.19
Options Exercisable, Number Exercisable (in shares) | shares	2,658,332
Options Exercisable, Weighted Average Remaining Contractual Life	3 years 6 months
Options Exercisable, Weighted Average Exercise Price Per Share (In dollars per share)	$ 56.19
$70.76 - $79.19
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range
Range of Exercise Prices, low end of range (in dollars per share)	70.76
Range of Exercise Prices, high end of range (in dollars per share)	$ 79.19
Options Outstanding, Number Outstanding (in shares) | shares	406,407
Options Outstanding, Weighted Average Remaining Contractual Life	2 years 1 month 6 days
Options Outstanding, Weighted Average Exercise Price Per Share (in dollars per share)	$ 79.19
Options Exercisable, Number Exercisable (in shares) | shares	404,562
Options Exercisable, Weighted Average Remaining Contractual Life	2 years 1 month 6 days
Options Exercisable, Weighted Average Exercise Price Per Share (In dollars per share)	$ 79.19