Stock-Based Compensation - Restricted Stock, Restricted Stock Unit and Stock Option Activity, Terms and Significant Assumptions for Options (Details) - $ / shares	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
RSU or Restricted Stock
Restricted Stock Units or Restricted Stock, Number
Beginning balance (in shares)	2,258,594	1,660,311	985,132
Granted (in shares)	596,391	1,355,975	1,356,303
Expired or canceled (in shares)	(132,713)	(114,352)	(173,604)
Vested/exercised (in shares)	(810,560)	(643,340)	(507,520)
Ending balance (in shares)	1,911,712	2,258,594	1,660,311
Restricted Stock Units or Restricted Stock, Weighted Average Grant Date Fair Value Per Share
Beginning balance (in dollars per share)	$ 21.76	$ 39.88	$ 53.78
Granted (in dollars per share)	18.67	10.30	32.68
Expired or canceled (in dollars per share)	18.78	33.74	39.57
Vested/exercised (in dollars per share)	30.83	42.23	47.72
Ending balance (in dollars per share)	$ 17.16	$ 21.76	$ 39.88
Stock Options
Stock Options, Number
Beginning balance (in shares)	5,752,932	5,381,477	4,589,385
Granted (in shares)	481,626	975,290	1,192,108
Expired or canceled (in shares)	(659,216)	(603,835)	(351,885)
Vested/exercised (in shares)	(84,416)	0	(48,131)
Ending balance (in shares)	5,490,926	5,752,932	5,381,477
Options exercisable (in shares)	3,519,747
Remaining unvested options outstanding and expected to vest (in shares)	1,951,467
Stock Options, Weighted Average Exercise Price Per Share
Beginning balance (in dollars per share)	$ 44.40	$ 52.13	$ 60.25
Granted (in dollars per share)	17.96	11.06	22.47
Expired or canceled (in dollars per share)	58.37	59.46	60.56
Vested/exercised (in dollars per share)	8.81	0	30.46
Ending balance (in dollars per share)	40.95	$ 44.40	$ 52.13
Options exercisable (in dollars per share)	54.31
Remaining unvested options outstanding and expected to vest (in dollars per share)	$ 17.09