SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)

6 Months Ended

Jun. 30, 2019

Schedule of available-for-sale securities

Available-for-sale securities at June 30, 2019 consisted of the following:

	June 30, 2019
			Gains in Accumulated		Losses in Accumulated
			Other Comprehensive		Other Comprehensive		Estimated Fair
(In thousands)	Amortized Cost		Income (Loss) (1)		Income (Loss) (1)		Value
Marketable securities
Corporate bonds	$	447,169	$	1,368	$	(6)	$	448,531
Asset backed securities		291,973		899		(18)		292,854
U.S. government agency securities		219,811		362		—		220,173
Commercial paper		16,899		—		(1)		16,898
Certificates of deposit		55,781		128		(1)		55,908
Total available-for-sale securities	$	1,031,633	$	2,757	$	(26)	$	1,034,364

(1) Gains and losses in accumulated other comprehensive income (loss) are reported before tax impact.

Available-for-sale securities at December 31, 2018 consisted of the following:

	December 31, 2018
			Gains in Accumulated		Losses in Accumulated
			Other Comprehensive		Other Comprehensive		Estimated Fair
(In thousands)	Amortized Cost		Income (Loss) (1)		Income (Loss) (1)		Value
Corporate bonds	$	392,973	$	33	$	(719)	$	392,287
Asset backed securities		277,537		30		(568)		276,999
U.S. government agency securities		250,606		43		(178)		250,471
Commercial paper		12,158		—		(7)		12,151
Certificates of deposit		31,875		—		(31)		31,844
Total available-for-sale securities	$	965,149	$	106	$	(1,503)	$	963,752

Schedule of amounts recognized in accumulated other comprehensive income (loss) (AOCI)

The amount recognized in accumulated other comprehensive income (loss) (“AOCI”) for the six months ended June 30, 2019 were as follows:

	Foreign		Unrealized		Accumulated
	Currency		Gain (Loss)		Other
	Translation		on Marketable		Comprehensive
(In thousands)	Adjustments		Securities		Income (Loss)
Balance at December 31, 2018	$	(25)	$	(1,397)	$	(1,422)
Other comprehensive income (loss) before reclassifications		38		3,784		3,822
Amounts reclassified from accumulated other comprehensive loss		—		344		344
Net current period change in accumulated other comprehensive loss, before tax		38		4,128		4,166
Income tax expense related to items of other comprehensive income		—		(984)		(984)
Balance at June 30, 2019	$	13	$	1,747	$	1,760

The amounts recognized in AOCI for the six months ended June 30, 2018 were as follows:

					Accumulated
	Cumulative		Unrealized		Other
	Translation		Gain (Loss)		Comprehensive
(In thousands)	Adjustment		on Securities		Income (Loss)
Balance at December 31, 2017	$	(61)	$	(689)	$	(750)
Other comprehensive loss before reclassifications		2		(1,244)		(1,242)
Amounts reclassified from accumulated other comprehensive loss		—		114		114
Net current period change in accumulated other comprehensive loss		2		(1,130)		(1,128)
Balance at June 30, 2018	$	(59)	$	(1,819)	$	(1,878)

Schedule of amounts reclassified from accumulated other comprehensive income (loss)

Amounts reclassified from AOCI for the six months ended June 30, 2019 and 2018 were as follows:

	Affected Line Item in the	Six Months Ended June 30,
Details about AOCI Components (In thousands)	Statements of Operations	2019		2018
Change in value of available-for-sale investments
Sales and maturities of available-for-sale investments	Investment income	$	344	$	114
Total reclassifications		$	344	$	114

Schedule of Property, plant and equipment, net

	Estimated		June 30,		December 31,
(In thousands)	Useful Life		2019		2018
Property, plant and equipment
Land		(1)	$	4,466	$	4,466
Leasehold and building improvements		(2)		59,796		38,895
Land improvements		15 years		1,766		1,530
Buildings		30 years		18,086		7,928
Computer equipment and computer software		3 years		38,225		36,969
Laboratory equipment		3 - 10 years		66,347		37,518
Furniture and fixtures		3 years		11,267		8,353
Assets under construction		(3)		206,120		167,462
Property, plant and equipment, at cost				406,073		303,121
Accumulated depreciation				(70,574)		(57,862)
Property, plant and equipment, net			$	335,499	$	245,259

(1) Not depreciated.

(2) Lesser of remaining lease term, building life, or useful life.

(3) Not depreciated until placed into service.

Schedule of Goodwill and Intangible assets

	June 30,		December 31,
(In thousands)	2019		2018
Finite-lived intangible assets
Finite-lived intangible assets	$	33,171	$	33,058
Less: Accumulated amortization		(5,722)		(4,107)
Finite-lived intangible assets, net		27,449		28,951
Internally developed technology in process		318		51
Total finite-lived intangible assets, net		27,767		29,002
Goodwill		17,279		17,279
Goodwill and intangible assets, net	$	45,046	$	46,281

Schedule of net-book value and estimated remaining life and finite lived intangible assets

			Weighted
	Net Balance at		Average
	June 30,		Remaining
(In thousands)	2019		Life (Years)
Trade name	$	665		14.3
Customer relationships		2,566		14.3
Patents		17,846		9.2
Acquired developed technology		5,836		13.3
Internally developed technology		536		2.4
Total	$	27,449

As of June 30, 2019, the estimated future amortization expense associated with the Company’s finite-lived intangible assets for each of the five succeeding fiscal years is as follows:

(In thousands)
2019	$	1,614
2020		3,231
2021		3,129
2022		2,967
2023		2,953
Thereafter		13,555
	$	27,449

Schedule of estimated future amortization expense, intangible assets

			Weighted
	Net Balance at		Average
	June 30,		Remaining
(In thousands)	2019		Life (Years)
Trade name	$	665		14.3
Customer relationships		2,566		14.3
Patents		17,846		9.2
Acquired developed technology		5,836		13.3
Internally developed technology		536		2.4
Total	$	27,449

Schedule of potentially issuable common shares not included in the computation of diluted net loss per share because they would have an anti-dilutive effect

	June 30,
(In thousands)	2019	2018
Shares issuable upon exercise of stock options	2,387	2,918
Shares issuable upon the release of restricted stock awards	4,123	6,312
Shares issuable upon conversion of convertible notes	12,197	12,044
	18,707	21,274

Schedule of disaggregation of revenue

	Three Months Ended June 30,
(In thousands)	2019		2018
Medicare Parts B & C	$	103,569	$	59,706
Commercial		88,818		39,589
Other		7,483		3,599
Total	$	199,870	$	102,894

	Six Months Ended June 30,
(In thousands)	2019		2018
Medicare Parts B & C	$	186,486	$	112,181
Commercial		162,169		74,423
Other		13,258		6,586
Total	$	361,913	$	193,190

Schedule of inventory

Inventory consisted of the following:

	June 30,		December 31,
(In thousands)	2019		2018
Raw materials	$	15,473	$	12,761
Semi-finished and finished goods		32,308		26,387
Total inventory	$	47,781	$	39,148