SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)

3 Months Ended

Mar. 31, 2018

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Schedule of available-for-sale securities

Available-for-sale securities at March 31, 2018 consisted of the following:

	March 31, 2018
			Gains in Accumulated		Losses in Accumulated
			Other Comprehensive		Other Comprehensive		Estimated Fair
(In thousands)	Amortized Cost		Income (Loss)		Income (Loss)		Value
Corporate bonds	$	346,193		3		(1,073)	$	345,123
Asset backed securities		254,390		—		(843)		253,547
U.S. government agency securities		194,307		—		(283)		194,024
Commercial paper		52,015		—		(21)		51,994
Certificates of deposit		48,864		1		(79)		48,786
Total available-for-sale securities	$	895,769	$	4	$	(2,299)	$	893,474

Available-for-sale securities at December 31, 2017 consisted of the following:

	December 31, 2017
			Gains in Accumulated		Losses in Accumulated
			Other Comprehensive		Other Comprehensive		Estimated Fair
(In thousands)	Amortized Cost		Income (Loss)		Income (Loss)		Value
Corporate bonds	$	181,639	$	10	$	(344)	$	181,305
Asset backed securities		94,700		—		(185)		94,515
U.S. government agency securities		54,974		—		(162)		54,812
Commercial paper		9,953		—		(7)		9,946
Certificates of deposit		6,647		1		(2)		6,646
Total available-for-sale securities	$	347,913	$	11	$	(700)	$	347,224

Schedule of amounts recognized in accumulated other comprehensive income (loss) (AOCI)

The amounts recognized in accumulated other comprehensive income (loss) (“AOCI”) for the three months ended March 31, 2018 were as follows:

					Accumulated
	Cumulative		Unrealized		Other
	Translation		Gain (Loss)		Comprehensive
(In thousands)	Adjustment		on Securities		Income (Loss)
Balance at December 31, 2017	$	(61)	$	(689)	$	(750)
Other comprehensive loss before reclassifications		20		(1,630)		(1,610)
Amounts reclassified from accumulated other comprehensive loss		—		24		24
Net current period change in accumulated other comprehensive loss		20		(1,606)		(1,586)
Balance at March 31, 2018	$	(41)	$	(2,295)	$	(2,336)

The amounts recognized in AOCI for the three months ended March 31, 2017 were as follows:

					Accumulated
	Cumulative		Unrealized		Other
	Translation		Gain (Loss)		Comprehensive
(In thousands)	Adjustment		on Securities		Income (Loss)
Balance at December 31, 2016	$	(204)	$	(214)	$	(418)
Other comprehensive loss before reclassifications		(8)		(3)		(11)
Amounts reclassified from accumulated other comprehensive loss		—		(2)		(2)
Net current period change in accumulated other comprehensive loss		(8)		(5)		(13)
Balance at March 31, 2017	$	(212)	$	(219)	$	(431)

Schedule of amounts reclassified from accumulated other comprehensive income (loss)

Amounts reclassified from AOCI for the three months ended March 31, 2018 and 2017 were as follows:

	Affected Line Item in the	Three Months Ended March 31,
Details about AOCI Components (In thousands)	Statement of Operations	2018		2017
Change in value of available-for-sale investments
Sales and maturities of available-for-sale investments	Investment income	$	24	$	(2)
Total reclassifications		$	24	$	(2)

Schedule of Property, plant and equipment, net

	Estimated		March 31,		December 31,
(In thousands)	Useful Life		2018		2017
Property, plant and equipment
Land		(1)	$	4,466	$	4,466
Leasehold and building improvements		(2)		17,452		17,629
Land improvements		15 years		1,419		1,419
Buildings		30 years		7,928		7,928
Computer equipment and computer software		3 years		32,716		30,148
Laboratory equipment		3 - 5 years		26,234		23,296
Furniture and fixtures		3 years		4,554		4,531
Assets under construction		(3)		50,922		28,655
Property, plant and equipment, at cost				145,691		118,072
Accumulated depreciation				(42,243)		(38,086)
Property, plant and equipment, net			$	103,448	$	79,986

(1) Not depreciated.

(2) Lesser of the remaining lease term, building life, or useful life.

(3) Not depreciated until placed into service.

Schedule of intangible assets

	March 31,		December 31,
(In thousands)	2018		2017
Intangible assets:
Finite-lived intangible assets	$	23,660	$	23,660
Less: Accumulated amortization		(2,102)		(1,500)
Net carrying value	$	21,558	$	22,160

Schedule of net-book value and estimated remaining life and finite lived intangible assets

			Weighted
	Net Balance at		Average
	March 31,		Remaining
(In thousands)	2018		Life (Years)
Licensed intellectual property and patents	$	20,675		10.2
Developed technology		883		7.3
Total	$	21,558

Schedule of estimated future amortization expense, intangible assets

The table below represents estimated future amortization expense associated with the Company’s finite-lived intangible assets as of March 31, 2018:

(In thousands)
2018	$	1,805
2019		2,407
2020		2,407
2021		2,373
2022		2,370
Thereafter		10,196
	$	21,558

Schedule of potentially issuable common shares not included in the computation of diluted net loss per share because they would have an anti-dilutive effect

	March 31,
(In thousands)	2018	2017
Shares issuable upon exercise of stock options	3,284	3,613
Shares issuable upon the release of restricted stock awards	6,315	5,553
Shares issuable upon conversion of convertible notes	9,148	—
	18,747	9,166

Schedule of disaggregation or revenue source

	Three Months Ended March 31,
(In thousands)	2018		2017
Medicare Parts B & C	$	52,475	$	31,812
Commercial		34,834		15,136
Other		2,987		1,415
Total	$	90,296	$	48,363

Schedule of inventory

Inventory consists of the following:

	March 31,		December 31,
(In thousands)	2018		2017
Raw materials	$	10,935	$	10,344
Semi-finished and finished goods		21,445		15,683
Total inventory	$	32,380	$	26,027