Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Current Assets:
Cash and cash equivalents	$ 180,407	$ 48,921
Marketable securities	303,853	262,179
Accounts receivable, net	22,591	8,526
Inventory, net	12,410	6,833
Prepaid expenses and other current assets	6,872	7,114
Total current assets	526,133	333,573
Property and Equipment, at cost:
Computer equipment and computer software	24,802	20,767
Laboratory equipment	18,258	14,749
Leasehold improvements	13,682	13,549
Assets under construction	9,095	6,711
Buildings	4,792	4,792
Furniture and fixtures	2,897	2,515
Property and Equipment, gross	73,526	63,083
Less-Accumulated depreciation	(31,478)	(24,941)
Net property and equipment	42,048	38,142
Other long-term assets	14,420	5,325
Total assets	582,601	377,040
Current Liabilities:
Accounts payable	2,237	710
Accrued liabilities	26,935	28,106
Debt, current portion	178	174
Other short-term liabilities	1,943	1,702
Total current liabilities	31,293	30,692
Long-term debt	4,552	4,633
Other long-term liabilities	5,684	5,734
Lease incentive obligation, less current portion	378	686
Total liabilities	41,907	41,745
Commitments and contingencies
Stockholders' Equity:
Preferred stock, $0.01 par value Authorized—5,000,000 shares issued and outstanding—no shares at June 30, 2017 and December 31, 2016
Common stock, $0.01 par value Authorized—200,000,000 shares issued and outstanding—119,048,783 and 110,236,127 shares at March 31, 2017 and December 31, 2016	1,190	1,102
Additional paid-in capital	1,351,836	1,080,432
Accumulated other comprehensive loss	(379)	(418)
Accumulated deficit	(811,953)	(745,821)
Total stockholders' equity	540,694	335,295
Total liabilities and stockholders’ equity	$ 582,601	$ 377,040