MAYO LICENSE AGREEMENT (Details)						1 Months Ended			3 Months Ended								12 Months Ended			18 Months Ended
	Jul. 24, 2015 shares	Dec. 16, 2014 shares	Apr. 02, 2014 shares	Jun. 21, 2013 shares	Jun. 30, 2009 item $ / shares shares	Jan. 31, 2016 USD ($)	Aug. 31, 2014 USD ($)	Sep. 30, 2011 shares	Dec. 31, 2015 USD ($)	Sep. 30, 2015 USD ($)	Jun. 30, 2015 USD ($)	Mar. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Sep. 30, 2014 USD ($)	Jun. 30, 2014 USD ($)	Mar. 31, 2014 USD ($)	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($)	Jun. 30, 2014 shares	Feb. 28, 2015 USD ($) installment	Dec. 31, 2009 shares
Warrants
Number of shares of common stock covered by warrants | shares																						75,000
Other Payments
Charges incurred as part of the research collaboration									$ 9,365,000	$ 9,863,000	$ 8,115,000	$ 6,571,000	$ 4,992,000	$ 9,073,000	$ 7,174,000	$ 7,430,000	$ 33,914,000	$ 28,669,000	$ 27,678,000
Amendments
Number of shares of restricted stock granted as a consideration for the expanded license | shares	7,000,000	4,000,000	11,500,000	6,300,000
Licensing Agreements | MAYO
Warrants
Number of common stock purchase warrants granted | item					2
Exercise price (in dollars per share) | $ / shares					$ 1.90
Value of common stock required to be issued upon commercial launch of second and third products						$ 200,000
Other Payments
Milestone payment contingent upon FDA approval							$ 500,000
Charges incurred as part of the research collaboration																	2,600,000	2,300,000	1,700,000
Payments for research and development efforts																	2,600,000	700,000	$ 1,000,000
Estimated liability for research and development efforts									$ 1,300,000				$ 1,500,000				$ 1,300,000	$ 1,500,000
Amendments
Time period after the last licensed patent expires that the license agreement will remain in effect																	5 years
License fees payable in five annual installments																					$ 5,000,000
Number of annual installments in which license fees are payable | installment																					5
Licensing Agreements | Minimum | MAYO
Warrants
Royalty payments																	$ 25,000
Licensing Agreements | Warrant Covering One Million Shares | MAYO
Warrants
Number of shares of common stock covered by warrants | shares					1,000,000
Warrants exercised, gross (in shares) | shares								1,000,000
Licensing Agreements | Warrant Covering Two Hundred Fifty Thousand Shares | MAYO
Warrants
Number of shares of common stock covered by warrants | shares					250,000
Warrants exercised, gross (in shares) | shares																				250,000
Sales Milestone Range One | Licensing Agreements | MAYO
Warrants
Amount agreed to be paid upon reaching the specified amount of net sales						200,000
Net sales of a licensed product						5,000,000
Sales Milestone Range Two | Licensing Agreements | MAYO
Warrants
Amount agreed to be paid upon reaching the specified amount of net sales						750,000
Net sales of a licensed product						20,000,000
Sales Milestone Range Three | Licensing Agreements | MAYO
Warrants
Amount agreed to be paid upon reaching the specified amount of net sales						2,000,000
Net sales of a licensed product						$ 50,000,000