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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001399775-09-000010.txt : 20090616
<SEC-HEADER>0001399775-09-000010.hdr.sgml : 20090616
<ACCEPTANCE-DATETIME>20090616160501
ACCESSION NUMBER:		0001399775-09-000010
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090616
DATE AS OF CHANGE:		20090616
EFFECTIVENESS DATE:		20090616

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXACT SCIENCES CORP
		CENTRAL INDEX KEY:			0001124140
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				204782291
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-46081
		FILM NUMBER:		09894171

	BUSINESS ADDRESS:	
		STREET 1:		100 CAMPUS DRIVE
		CITY:			MARLBOROUGH
		STATE:			MA
		ZIP:			01752
		BUSINESS PHONE:		5086831200

	MAIL ADDRESS:	
		STREET 1:		100 CAMPUS DRIVE
		CITY:			MARLBOROUGH
		STATE:			MA
		ZIP:			01752

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXACT CORP
		DATE OF NAME CHANGE:	20000919
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0401</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001124140</cik>
        <entityName>EXACT SCIENCES CORP</entityName>
        <issuerAddress>
            <street1>100 Campus Drive</street1>
            <street2></street2>
            <city>Marlborough</city>
            <stateOrCountry>MA</stateOrCountry>
            <zipCode>01752</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>5086831200</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>EXACT CORP</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kevin</firstName>
                <middleName>T</middleName>
                <lastName>Conroy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 S. Rosa Road, Suite 123</street1>
                <street2></street2>
                <city>Madison</city>
                <stateOrCountry>WI</stateOrCountry>
                <zipCode>53719</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Maneesh</firstName>
                <middleName></middleName>
                <lastName>Arora</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 S. Rosa Road, Suite 123</street1>
                <street2></street2>
                <city>Madison</city>
                <stateOrCountry>WI</stateOrCountry>
                <zipCode>53719</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Patrick</firstName>
                <middleName>J</middleName>
                <lastName>Zenner</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 S. Rosa Road, Suite 123</street1>
                <street2></street2>
                <city>Madison</city>
                <stateOrCountry>WI</stateOrCountry>
                <zipCode>53719</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Sally</firstName>
                <middleName>W</middleName>
                <lastName>Crawford</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 S. Rosa Road, Suite 123</street1>
                <street2></street2>
                <city>Madison</city>
                <stateOrCountry>WI</stateOrCountry>
                <zipCode>53719</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Connie</firstName>
                <middleName></middleName>
                <lastName>Mack III</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 S. Rosa Road, Suite 123</street1>
                <street2></street2>
                <city>Madison</city>
                <stateOrCountry>WI</stateOrCountry>
                <zipCode>53719</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Lance</firstName>
                <middleName></middleName>
                <lastName>Willsey, MD</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 S. Rosa Road, Suite 123</street1>
                <street2></street2>
                <city>Madison</city>
                <stateOrCountry>WI</stateOrCountry>
                <zipCode>53719</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName></middleName>
                <lastName>Singer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 S. Rosa Road, Suite 123</street1>
                <street2></street2>
                <city>Madison</city>
                <stateOrCountry>WI</stateOrCountry>
                <zipCode>53719</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Katherine</firstName>
                <middleName></middleName>
                <lastName>Napier</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 S. Rosa Road, Suite 123</street1>
                <street2></street2>
                <city>Madison</city>
                <stateOrCountry>WI</stateOrCountry>
                <zipCode>53719</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName></middleName>
                <lastName>Connelly</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 S. Rosa Road, Suite 123</street1>
                <street2></street2>
                <city>Madison</city>
                <stateOrCountry>WI</stateOrCountry>
                <zipCode>53719</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-06-11</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>200000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>8200000</totalOfferingAmount>
            <totalAmountSold>8200000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>11</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>EXACT SCIENCES CORP</issuerName>
                <signatureName>Maneesh Arora</signatureName>
                <nameOfSigner>Maneesh Arora</nameOfSigner>
                <signatureTitle>Senior VP and CFO</signatureTitle>
                <signatureDate>2009-06-12</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----