X0508 4 2024-02-29 0 0001124140 EXACT SCIENCES CORP EXAS 0001957680 Herriott James C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 General Counsel 1 Common Stock 2024-02-29 4 M 0 1890 0.00 A 9987 D Common Stock 2024-03-01 4 S 0 862 59.32 D 9125 D Common Stock 1183 I Held in 401(k) Plan Restricted Stock Units 2024-02-29 4 M 0 1890 0.00 D Common Stock 1890 5670 D Represents shares of common stock received upon vesting of a restricted stock unit award. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units. In addition to the shares of Common Stock reported on this Form 4, which total 10,308 shares, Mr. Herriott also holds, in the aggregate, an additional 22,982 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. Represents a restricted stock unit award that partially vested on February 29, 2024. The restricted stock units vest in four equal annual installments from the grant date. /s/ James Herriott by Mark R. Busch, attorney-in-fact 2024-03-04