X0508 4 2024-02-23 0 0001124140 EXACT SCIENCES CORP EXAS 0001839989 Condella Sarah C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 EVP, Human Resources 1 Common Stock 2024-02-23 4 S 0 1021 59.72 D 71658 D Common Stock 5726 I Held in 401(k) Plan The transaction reported in this field was effected pursuant to a Rule 10b5-1 trading plan entered into on May 18, 2023. In addition to the shares of Common Stock reported on this Form 4, which total 77,384 shares, Ms. Condella also holds, in the aggregate, an additional 81,149 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ Sarah Condella by Mark R. Busch, attorney-in-fact 2024-02-26